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Retroperitoneal leiomyosarcoma

MedGen UID:
412162
•Concept ID:
C2187547
•
Neoplastic Process
Synonyms: leiomyosarcoma of retroperitoneal space; Retroperitoneal Leiomyosarcoma; retroperitoneal leiomyosarcoma; retroperitoneal space leiomyosarcoma
 
Monarch Initiative: MONDO:0003370

Definition

An aggressive malignant smooth muscle neoplasm, arising from the retroperitoneum. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetroperitoneal leiomyosarcoma

Professional guidelines

PubMed

Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue.
Snyder M, Gangadhara S, Brohl AS, Ludlow S, Nanjappa S
Cancer Control 2017 Oct-Dec;24(5):1073274817729070. doi: 10.1177/1073274817729070. PMID: 28975823Free PMC Article
Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma.
Leu KM, Ostruszka LJ, Shewach D, Zalupski M, Sondak V, Biermann JS, Lee JS, Couwlier C, Palazzolo K, Baker LH
J Clin Oncol 2004 May 1;22(9):1706-12. doi: 10.1200/JCO.2004.08.043. PMID: 15117993

Recent clinical studies

Etiology

A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Potential application value of PET/computed tomography in retroperitoneal leiomyosarcoma and a literature review.
Gao YJ, Yang Z, Yu JY, Li N, Wang XJ, Zhou NN
Nucl Med Commun 2021 Jul 1;42(7):800-810. doi: 10.1097/MNM.0000000000001388. PMID: 33741860
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Nathenson MJ, Barysauskas CM, Nathenson RA, Regine WF, Hanna N, Sausville E
World J Surg Oncol 2018 Oct 11;16(1):203. doi: 10.1186/s12957-018-1505-4. PMID: 30309356Free PMC Article
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery.
Ikoma N, Torres KE, Lin HY, Ravi V, Roland CL, Mann GN, Hunt KK, Cormier JN, Feig BW
J Surg Oncol 2017 Sep;116(3):313-319. Epub 2017 May 29 doi: 10.1002/jso.24667. PMID: 28557016Free PMC Article
Retroperitoneal leiomyosarcoma: a review of the literature.
Fisher NW, Nutinsky CL
J Am Osteopath Assoc 1989 Aug;89(8):1058-60, 1065. PMID: 2670858

Diagnosis

A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Nathenson MJ, Barysauskas CM, Nathenson RA, Regine WF, Hanna N, Sausville E
World J Surg Oncol 2018 Oct 11;16(1):203. doi: 10.1186/s12957-018-1505-4. PMID: 30309356Free PMC Article
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery.
Ikoma N, Torres KE, Lin HY, Ravi V, Roland CL, Mann GN, Hunt KK, Cormier JN, Feig BW
J Surg Oncol 2017 Sep;116(3):313-319. Epub 2017 May 29 doi: 10.1002/jso.24667. PMID: 28557016Free PMC Article
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma.
Ishii T, Kohashi K, Ootsuka H, Iura K, Maekawa A, Yamada Y, Bekki H, Yoshimoto M, Yamamoto H, Iwamoto Y, Oda Y
Pathol Res Pract 2017 Jun;213(6):634-638. Epub 2017 May 1 doi: 10.1016/j.prp.2017.04.022. PMID: 28552535
Retroperitoneal leiomyosarcoma.
De Waele B, Van Belle S, Claes H, Goovaerts G, Delvaux G, Willems G
Acta Chir Belg 1987 Jul-Aug;87(4):229-34. PMID: 3661002

Therapy

TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group.
Fabbroni C, Grignani G, Vincenzi B, Fumagalli E, De Pas TM, Mazzocca A, Pantaleo MA, Brunello A, Baldi GG, Boglione A, Fatigoni S, Berruti A, Giordano M, Marrari A, Dei Tos AP, Alberton AS, Aliberti S, Carlucci L, Rulli E, Casali PG, Sanfilippo R
ESMO Open 2024 Aug;9(8):103667. Epub 2024 Aug 8 doi: 10.1016/j.esmoop.2024.103667. PMID: 39121815Free PMC Article
Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients.
Zhuang A, Yue X, Tong H, Zhang Y, He F, Lu W
Front Endocrinol (Lausanne) 2023;14:1160817. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1160817. PMID: 37534215Free PMC Article
Tumour-bowel fistula as a possible complication of pazopanib therapy in retroperitoneal leiomyosarcoma.
Pereira ROL, Patel PR, Guru PK, Sanghavi DK
BMJ Case Rep 2019 Nov 10;12(11) doi: 10.1136/bcr-2019-230727. PMID: 31712231Free PMC Article
Outcome of iliocaval resection and reconstruction for retroperitoneal sarcoma.
Ferraris M, Callegaro D, Barretta F, Fiore M, Radaelli S, Stacchiotti S, Miceli R, Socrate AM, Locati P, Gronchi A
J Vasc Surg Venous Lymphat Disord 2019 Jul;7(4):547-556. Epub 2019 Feb 18 doi: 10.1016/j.jvsv.2018.10.023. PMID: 30792153
Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue.
Snyder M, Gangadhara S, Brohl AS, Ludlow S, Nanjappa S
Cancer Control 2017 Oct-Dec;24(5):1073274817729070. doi: 10.1177/1073274817729070. PMID: 28975823Free PMC Article

Prognosis

A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Nathenson MJ, Barysauskas CM, Nathenson RA, Regine WF, Hanna N, Sausville E
World J Surg Oncol 2018 Oct 11;16(1):203. doi: 10.1186/s12957-018-1505-4. PMID: 30309356Free PMC Article
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery.
Ikoma N, Torres KE, Lin HY, Ravi V, Roland CL, Mann GN, Hunt KK, Cormier JN, Feig BW
J Surg Oncol 2017 Sep;116(3):313-319. Epub 2017 May 29 doi: 10.1002/jso.24667. PMID: 28557016Free PMC Article
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma.
Ishii T, Kohashi K, Ootsuka H, Iura K, Maekawa A, Yamada Y, Bekki H, Yoshimoto M, Yamamoto H, Iwamoto Y, Oda Y
Pathol Res Pract 2017 Jun;213(6):634-638. Epub 2017 May 1 doi: 10.1016/j.prp.2017.04.022. PMID: 28552535
Retroperitoneal leiomyosarcoma.
De Waele B, Van Belle S, Claes H, Goovaerts G, Delvaux G, Willems G
Acta Chir Belg 1987 Jul-Aug;87(4):229-34. PMID: 3661002

Clinical prediction guides

TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group.
Fabbroni C, Grignani G, Vincenzi B, Fumagalli E, De Pas TM, Mazzocca A, Pantaleo MA, Brunello A, Baldi GG, Boglione A, Fatigoni S, Berruti A, Giordano M, Marrari A, Dei Tos AP, Alberton AS, Aliberti S, Carlucci L, Rulli E, Casali PG, Sanfilippo R
ESMO Open 2024 Aug;9(8):103667. Epub 2024 Aug 8 doi: 10.1016/j.esmoop.2024.103667. PMID: 39121815Free PMC Article
A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients.
Zhuang A, Yue X, Tong H, Zhang Y, He F, Lu W
Front Endocrinol (Lausanne) 2023;14:1160817. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1160817. PMID: 37534215Free PMC Article
CT imaging improves histopathological grading of retroperitoneal leiomyosarcomas.
Mcaddy NC, Hallin M, Strauss D, Smith M, Hayes A, Yusuf S, Moskovic E, Fotiadis N, van Houdt W, Jones RL, Gronchi A, Thway K, Messiou C
Eur J Surg Oncol 2020 Feb;46(2):288-292. Epub 2019 Oct 10 doi: 10.1016/j.ejso.2019.10.007. PMID: 31653457
Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma.
Li Q, Zhuang R, Zhu J, Lu W, Hou Y, Liu J, Zhang Y, Wang Y, Liu T, Wang Z, Zhou Y
Future Oncol 2015;11(12):1759-66. doi: 10.2217/fon.15.54. PMID: 26075444

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