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Oropharyngeal Human Papillomavirus-Related Squamous Cell Carcinoma

MedGen UID:
415751
•Concept ID:
C2828150
•
Neoplastic Process
Synonyms: HPV-Associated Oropharyngeal Squamous Cell Carcinoma; HPV-Positive Oropharyngeal Squamous Cell Carcinoma; Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma; Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma; Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma; Oropharyngeal HPV-Associated Squamous Cell Carcinoma; Oropharyngeal HPV-Positive Squamous Cell Carcinoma; Oropharyngeal HPV-Related Squamous Cell Carcinoma; Oropharyngeal Human Papillomavirus Positive Squamous Cell Carcinoma; Oropharyngeal Human Papillomavirus-Associated Squamous Cell Carcinoma; Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the oropharynx and is associated with human papillomavirus type 16 infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Human Papillomavirus-Related Squamous Cell Carcinoma

Professional guidelines

PubMed

Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent.
Autio TJ, Atula T, Jouhi L, Irjala H, Halme E, Jouppila-Mättö A, Mäkitie A, Koivunen P
Acta Otolaryngol 2023 Apr;143(4):328-333. Epub 2023 Mar 30 doi: 10.1080/00016489.2023.2188892. PMID: 36994865
Clinical Uncertainties of Circulating Tumor DNA in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in the Absence of National Comprehensive Cancer Network Guidelines.
Xie DX, Kut C, Quon H, Seiwert TY, D'Souza G, Fakhry C
J Clin Oncol 2023 May 10;41(14):2483-2487. Epub 2022 Dec 9 doi: 10.1200/JCO.22.00264. PMID: 36493337Free PMC Article
Mid-treatment Fluorodeoxyglucose Positron Emission Tomography in Human Papillomavirus-related Oropharyngeal Squamous Cell Carcinoma Treated with Primary Radiotherapy: Nodal Metabolic Response Rate can Predict Treatment Outcomes.
Lin P, Min M, Lai K, Lee M, Holloway L, Xuan W, Bray V, Fowler A, Lee CS, Yong J
Clin Oncol (R Coll Radiol) 2021 Dec;33(12):e586-e598. Epub 2021 Aug 7 doi: 10.1016/j.clon.2021.07.011. PMID: 34373179

Recent clinical studies

Etiology

Global epidemiologic patterns of oropharyngeal cancer incidence trends.
Zumsteg ZS, Luu M, Rosenberg PS, Elrod JK, Bray F, Vaccarella S, Gay C, Lu DJ, Chen MM, Chaturvedi AK, Goodman MT
J Natl Cancer Inst 2023 Dec 6;115(12):1544-1554. doi: 10.1093/jnci/djad169. PMID: 37603716Free PMC Article
Human papilomaviru-related oropharyngeal squamous cell carcinoma and radiomics: A new era?
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Distant metastases in human papillomavirus-related oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.
Crossley JR, Nelson LL, Chou J, Maxwell JH
Head Neck 2023 Jan;45(1):275-282. Epub 2022 Oct 28 doi: 10.1002/hed.27230. PMID: 36306202
High-Risk Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma Among Non-Indigenous and Indigenous Populations: A Systematic Review.
Ju X, Canfell K, Smith M, Sethi S, Garvey G, Hedges J, Logan RM, Antonsson A, Jamieson LM
Otolaryngol Head Neck Surg 2021 Jul;165(1):23-32. Epub 2020 Nov 24 doi: 10.1177/0194599820975042. PMID: 33228443
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362

Diagnosis

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Human papilomaviru-related oropharyngeal squamous cell carcinoma and radiomics: A new era?
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362
Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!
Lewis JS Jr
Mod Pathol 2017 Jan;30(s1):S44-S53. doi: 10.1038/modpathol.2016.152. PMID: 28060372
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Therapy

Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Palbociclib and cetuximab in cetuximab-resistant human papillomavirus-related oropharynx squamous-cell carcinoma: A multicenter phase 2 trial.
Oppelt P, Ley JC, Worden F, Palka K, Maggiore R, Liu J, Adkins D
Oral Oncol 2021 Mar;114:105164. Epub 2021 Jan 16 doi: 10.1016/j.oraloncology.2020.105164. PMID: 33465681
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
Radiation and chemotherapy with no excessive toxicity in a patient with human papillomavirus-related tonsillar cancer and porphyria cutanea tarda: Case report and literature review.
Russo JK, Braseth A
Head Neck 2017 Oct;39(10):E102-E109. Epub 2017 Aug 16 doi: 10.1002/hed.24771. PMID: 28815861
Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.
O'Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA
Oral Oncol 2012 Dec;48(12):1191-201. Epub 2012 Jul 28 doi: 10.1016/j.oraloncology.2012.06.019. PMID: 22841677

Prognosis

Global epidemiologic patterns of oropharyngeal cancer incidence trends.
Zumsteg ZS, Luu M, Rosenberg PS, Elrod JK, Bray F, Vaccarella S, Gay C, Lu DJ, Chen MM, Chaturvedi AK, Goodman MT
J Natl Cancer Inst 2023 Dec 6;115(12):1544-1554. doi: 10.1093/jnci/djad169. PMID: 37603716Free PMC Article
Human papilomaviru-related oropharyngeal squamous cell carcinoma and radiomics: A new era?
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Human Papillomavirus-Related Head and Neck Cancer.
Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann JP
Oncol Res Treat 2017;40(6):334-340. Epub 2017 May 19 doi: 10.1159/000477252. PMID: 28521311
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Clinical prediction guides

Global epidemiologic patterns of oropharyngeal cancer incidence trends.
Zumsteg ZS, Luu M, Rosenberg PS, Elrod JK, Bray F, Vaccarella S, Gay C, Lu DJ, Chen MM, Chaturvedi AK, Goodman MT
J Natl Cancer Inst 2023 Dec 6;115(12):1544-1554. doi: 10.1093/jnci/djad169. PMID: 37603716Free PMC Article
Impact of Tumor-Infiltrating Lymphocytes on Disease Progression in Human Papillomavirus-Related Oropharyngeal Carcinoma.
Yin LX, Rivera M, Garcia JJ, Bartemes KR, Lewis DB, Lohse CM, Routman DM, Ma DJ, Moore EJ, Van Abel KM
Otolaryngol Head Neck Surg 2023 Sep;169(3):539-547. Epub 2023 Jan 30 doi: 10.1002/ohn.249. PMID: 36939471
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362
E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer.
Hong A, Zhang X, Jones D, Zhang M, Lee CS, Lyons JG, Veillard AS, Rose B
Cancer Biol Ther 2016;17(2):181-7. Epub 2015 Nov 17 doi: 10.1080/15384047.2015.1108489. PMID: 26575468Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Distant metastases in human papillomavirus-related oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.
Crossley JR, Nelson LL, Chou J, Maxwell JH
Head Neck 2023 Jan;45(1):275-282. Epub 2022 Oct 28 doi: 10.1002/hed.27230. PMID: 36306202
High-Risk Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma Among Non-Indigenous and Indigenous Populations: A Systematic Review.
Ju X, Canfell K, Smith M, Sethi S, Garvey G, Hedges J, Logan RM, Antonsson A, Jamieson LM
Otolaryngol Head Neck Surg 2021 Jul;165(1):23-32. Epub 2020 Nov 24 doi: 10.1177/0194599820975042. PMID: 33228443
Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.
O'Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA
Oral Oncol 2012 Dec;48(12):1191-201. Epub 2012 Jul 28 doi: 10.1016/j.oraloncology.2012.06.019. PMID: 22841677

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