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Hyperplasia of the endometrium

MedGen UID:
41787
•Concept ID:
C0014173
•
Disease or Syndrome
Synonyms: Endometrial Hyperplasia; Endometrial Hyperplasias; Hyperplasia, Endometrial; Hyperplasias, Endometrial
SNOMED CT: Endometrial hyperplasia (237072009)
 
HPO: HP:0040298

Definition

A proliferation of the endometrial cells resulting in glandular enlargement and budding. The proliferation may or may not be associated with atypia of the endometrial cells. When the hyperplastic changes are excessive, there is formation of complex epithelial structures (complex endometrial hyperplasia). [from NCI]

Professional guidelines

PubMed

Fertility preserving management of early endometrial cancer in a patient cohort at the department of women's health at the university of Tuebingen.
Andress J, Pasternak J, Walter C, Kommoss S, Krämer B, Hartkopf A, Brucker SY, Schönfisch B, Steinmacher S
Arch Gynecol Obstet 2021 Jul;304(1):215-221. Epub 2021 Feb 19 doi: 10.1007/s00404-020-05905-8. PMID: 33606091Free PMC Article
Treatment for complex atypical hyperplasia of the endometrium.
Jobo T, Kawaguchi M, Imai M, Kuramoto H
Eur J Gynaecol Oncol 2001;22(5):365-8. PMID: 11766742
Assessment of the risk on endometrial cancer in hyperplasia, by means of morphological and morphometrical features.
Baak JP, Wisse-Brekelmans EC, Fleege JC, van der Putten HW, Bezemer PD
Pathol Res Pract 1992 Oct;188(7):856-9. doi: 10.1016/S0344-0338(11)80244-X. PMID: 1448376

Recent clinical studies

Etiology

Effectiveness of different methods for polypectomy in the menopause: a retrospective study.
Molnár S, Farkas Z, Jakab A, Lampé R, Török P
Climacteric 2020 Aug;23(4):325-329. doi: 10.1080/13697137.2020.1732915. PMID: 32648828
Patients with atypical hyperplasia of the endometrium should be treated in oncological centers.
Antonsen SL, Ulrich L, Høgdall C
Gynecol Oncol 2012 Apr;125(1):124-8. Epub 2011 Dec 20 doi: 10.1016/j.ygyno.2011.12.436. PMID: 22198048
Tamoxifen-induced hyperplasia of the endometrium.
Neis KJ, Brandner P, Schlenker M
Contrib Gynecol Obstet 2000;20:60-8. doi: 10.1159/000060285. PMID: 11791286
Progestins.
Hirvonen E
Maturitas 1996 May;23 Suppl:S13-8. doi: 10.1016/0378-5122(96)01005-5. PMID: 8865133
Adenomatous hyperplasia of the endometrium associated with delayed manifestation of estrogen-producing ovarian tumor: a case report.
Hunter CB
Am J Obstet Gynecol 1971 Jul 15;110(6):782-3. doi: 10.1016/0002-9378(71)90572-2. PMID: 5561997

Diagnosis

Effectiveness of different methods for polypectomy in the menopause: a retrospective study.
Molnár S, Farkas Z, Jakab A, Lampé R, Török P
Climacteric 2020 Aug;23(4):325-329. doi: 10.1080/13697137.2020.1732915. PMID: 32648828
Patients with atypical hyperplasia of the endometrium should be treated in oncological centers.
Antonsen SL, Ulrich L, Høgdall C
Gynecol Oncol 2012 Apr;125(1):124-8. Epub 2011 Dec 20 doi: 10.1016/j.ygyno.2011.12.436. PMID: 22198048
Endometrial hyperplasia/adenocarcinoma. a conventional approach.
Mazur MT
Ann Diagn Pathol 2005 Jun;9(3):174-81. doi: 10.1016/j.anndiagpath.2005.03.001. PMID: 15944963
Adenomatous hyperplasia of the endometrium associated with delayed manifestation of estrogen-producing ovarian tumor: a case report.
Hunter CB
Am J Obstet Gynecol 1971 Jul 15;110(6):782-3. doi: 10.1016/0002-9378(71)90572-2. PMID: 5561997
TICAS assessment of cells from atypical hyperplasia of the endometrium.
Wied GL, Bartels PH, Bahr GF, Reagan JW
Acta Cytol 1969 Oct;13(10):552-6. PMID: 5260005

Therapy

Patients with atypical hyperplasia of the endometrium should be treated in oncological centers.
Antonsen SL, Ulrich L, Høgdall C
Gynecol Oncol 2012 Apr;125(1):124-8. Epub 2011 Dec 20 doi: 10.1016/j.ygyno.2011.12.436. PMID: 22198048
Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome.
Kaku T, Yoshikawa H, Tsuda H, Sakamoto A, Fukunaga M, Kuwabara Y, Hataeg M, Kodama S, Kuzuya K, Sato S, Nishimura T, Hiura M, Nakano H, Iwasaka T, Miyazaki K, Kamura T
Cancer Lett 2001 Jun 10;167(1):39-48. doi: 10.1016/s0304-3835(01)00462-1. PMID: 11323097
Tamoxifen-induced hyperplasia of the endometrium.
Neis KJ, Brandner P, Schlenker M
Contrib Gynecol Obstet 2000;20:60-8. doi: 10.1159/000060285. PMID: 11791286
Progestins.
Hirvonen E
Maturitas 1996 May;23 Suppl:S13-8. doi: 10.1016/0378-5122(96)01005-5. PMID: 8865133
Anovulatory infertility associated with adenocarcinoma and adenomatous hyperplasia of the endometrium.
Aksel S, Wentz AC, Jones GS
Obstet Gynecol 1974 Mar;43(3):386-91. PMID: 4814456

Prognosis

Hysteroscopic Resection in Fertility-Sparing Surgery for Atypical Hyperplasia and Endometrial Cancer: Safety and Efficacy.
De Marzi P, Bergamini A, Luchini S, Petrone M, Taccagni GL, Mangili G, Colombo G, Candiani M
J Minim Invasive Gynecol 2015 Nov-Dec;22(7):1178-82. Epub 2015 Jun 16 doi: 10.1016/j.jmig.2015.06.004. PMID: 26092080
Complex atypical hyperplasia of the endometrium: differences in outcome following conservative management of pre- and postmenopausal women.
Brownfoot FC, Hickey M, Ang WC, Arora V, McNally O
Reprod Sci 2014 Oct;21(10):1244-8. Epub 2014 Feb 10 doi: 10.1177/1933719114522517. PMID: 24516039
Nodular histiocytic hyperplasia of the endometrium.
Kim KR, Lee YH, Ro JY
Int J Gynecol Pathol 2002 Apr;21(2):141-6. doi: 10.1097/00004347-200204000-00006. PMID: 11917223
Clinical significance of histiocytes in the detection of endometrial adenocarcinoma and hyperplasia.
Nguyen TN, Bourdeau JL, Ferenczy A, Franco EL
Diagn Cytopathol 1998 Aug;19(2):89-93. doi: 10.1002/(sici)1097-0339(199808)19:2<89::aid-dc3>3.0.co;2-i. PMID: 9702482
Adenomatous hyperplasia of the endometrium associated with delayed manifestation of estrogen-producing ovarian tumor: a case report.
Hunter CB
Am J Obstet Gynecol 1971 Jul 15;110(6):782-3. doi: 10.1016/0002-9378(71)90572-2. PMID: 5561997

Clinical prediction guides

Selective vs Complete Sampling in Hysterectomy Specimens Performed for Atypical Hyperplasia.
Bryant BH, Doughty E, Kalof AN
Am J Clin Pathol 2019 Oct 7;152(5):666-674. doi: 10.1093/ajcp/aqz098. PMID: 31332427
Hysteroscopic Resection in Fertility-Sparing Surgery for Atypical Hyperplasia and Endometrial Cancer: Safety and Efficacy.
De Marzi P, Bergamini A, Luchini S, Petrone M, Taccagni GL, Mangili G, Colombo G, Candiani M
J Minim Invasive Gynecol 2015 Nov-Dec;22(7):1178-82. Epub 2015 Jun 16 doi: 10.1016/j.jmig.2015.06.004. PMID: 26092080
Tamoxifen-induced hyperplasia of the endometrium.
Neis KJ, Brandner P, Schlenker M
Contrib Gynecol Obstet 2000;20:60-8. doi: 10.1159/000060285. PMID: 11791286
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848
Clinical significance of histiocytes in the detection of endometrial adenocarcinoma and hyperplasia.
Nguyen TN, Bourdeau JL, Ferenczy A, Franco EL
Diagn Cytopathol 1998 Aug;19(2):89-93. doi: 10.1002/(sici)1097-0339(199808)19:2<89::aid-dc3>3.0.co;2-i. PMID: 9702482

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