U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hepatitis D virus infection

MedGen UID:
4182
Concept ID:
C0011226
Disease or Syndrome
Synonyms: Delta Hepatitis; Delta Infection; Hepatitides, Delta; Hepatitis D; Hepatitis, Delta; Infection, Delta; Infections, Delta
SNOMED CT: Viral hepatitis type D (707341005); Viral hepatitis D (707341005); Hepatitis D virus infection (707341005); Hepatitis D (707341005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005789
Orphanet: ORPHA402823

Definition

Hepatitis delta is a rare hepatic disease characterized by variable degrees of acute hepatitis resulting from infection with the hepatitis delta virus. Occasionally it may present a benign course, but most frequently it manifests with severe liver disease that may include fulminant liver failure, hepatic decompensation and rapid progression to cirrhosis. All patients present concomitant hepatitis B virus infection and an increased risk of developing hepatocellular carcinoma has been reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis D virus infection

Professional guidelines

PubMed

Sandmann L, Berg T, Deterding K, Fischer N, Hinrichsen H, Petersen J, Tacke F, Cornberg M; Collaborators
Z Gastroenterol 2023 Dec;61(12):e715-e732. Epub 2023 Dec 11 doi: 10.1055/a-2181-3345. PMID: 38081178
Ito T, Nguyen MH
Lancet Infect Dis 2023 Jan;23(1):14-16. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00412-1. PMID: 36113539
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688

Recent clinical studies

Etiology

Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Jung S, Altstetter SM, Protzer U
World J Gastroenterol 2020 Jun 7;26(21):2781-2791. doi: 10.3748/wjg.v26.i21.2781. PMID: 32550754Free PMC Article
Alfaiate D, Clément S, Gomes D, Goossens N, Negro F
J Hepatol 2020 Sep;73(3):533-539. Epub 2020 Mar 6 doi: 10.1016/j.jhep.2020.02.030. PMID: 32151618
Jackson C, Gunson RN, Bradley-Stewart A, Bennett S, Black H, Kennedy N, Bell DJ
J Viral Hepat 2018 Nov;25(11):1395-1396. Epub 2018 Jun 28 doi: 10.1111/jvh.12939. PMID: 29851188
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

Diagnosis

Demirel A, Uraz S, Deniz Z, Daglilar E, Basar O, Tahan V, Ozaras R
J Viral Hepat 2024 Feb;31(2):120-128. Epub 2023 Nov 14 doi: 10.1111/jvh.13899. PMID: 37964693
Sandmann L, Berg T, Deterding K, Fischer N, Hinrichsen H, Petersen J, Tacke F, Cornberg M; Collaborators
Z Gastroenterol 2023 Dec;61(12):e715-e732. Epub 2023 Dec 11 doi: 10.1055/a-2181-3345. PMID: 38081178
Asselah T, Rizzetto M
N Engl J Med 2023 Jul 6;389(1):58-70. doi: 10.1056/NEJMra2212151. PMID: 37407002
Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Jackson C, Gunson RN, Bradley-Stewart A, Bennett S, Black H, Kennedy N, Bell DJ
J Viral Hepat 2018 Nov;25(11):1395-1396. Epub 2018 Jun 28 doi: 10.1111/jvh.12939. PMID: 29851188

Therapy

Roca TP, Queiroz JAS, Passos-Silva AM, Araújo A, Lago BV, Mello FCA, Salcedo JMV, Vieira D, Villar LM
Viruses 2024 Oct 29;16(11) doi: 10.3390/v16111690. PMID: 39599805Free PMC Article
Sandmann L, Berg T, Deterding K, Fischer N, Hinrichsen H, Petersen J, Tacke F, Cornberg M; Collaborators
Z Gastroenterol 2023 Dec;61(12):e715-e732. Epub 2023 Dec 11 doi: 10.1055/a-2181-3345. PMID: 38081178
Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Jackson C, Gunson RN, Bradley-Stewart A, Bennett S, Black H, Kennedy N, Bell DJ
J Viral Hepat 2018 Nov;25(11):1395-1396. Epub 2018 Jun 28 doi: 10.1111/jvh.12939. PMID: 29851188

Prognosis

Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688
Toukan AU
Prog Clin Biol Res 1993;382:251-8. PMID: 8502689
Kage M, Kosai K, Shimamatsu K, Nakashima O, Haramaki M, Yasunaga M, Iha H, Kojiro M, Govindarajan S
Kurume Med J 1992;39(4):231-4. doi: 10.2739/kurumemedj.39.231. PMID: 1339069

Clinical prediction guides

Roca TP, Queiroz JAS, Passos-Silva AM, Araújo A, Lago BV, Mello FCA, Salcedo JMV, Vieira D, Villar LM
Viruses 2024 Oct 29;16(11) doi: 10.3390/v16111690. PMID: 39599805Free PMC Article
Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Alfaiate D, Clément S, Gomes D, Goossens N, Negro F
J Hepatol 2020 Sep;73(3):533-539. Epub 2020 Mar 6 doi: 10.1016/j.jhep.2020.02.030. PMID: 32151618
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688

Recent systematic reviews

Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Alfaiate D, Clément S, Gomes D, Goossens N, Negro F
J Hepatol 2020 Sep;73(3):533-539. Epub 2020 Mar 6 doi: 10.1016/j.jhep.2020.02.030. PMID: 32151618
Chen HY, Shen DT, Ji DZ, Han PC, Zhang WM, Ma JF, Chen WS, Goyal H, Pan S, Xu HG
Gut 2019 Mar;68(3):512-521. Epub 2018 Sep 18 doi: 10.1136/gutjnl-2018-316601. PMID: 30228220
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...