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Focal epilepsy

MedGen UID:
41836
•Concept ID:
C0014547
•
Disease or Syndrome
Synonym: partial epilepsy
SNOMED CT: Focal epilepsy (230381009); Localization-related epilepsy (230381009)
 
Monarch Initiative: MONDO:0005384

Definition

A type of epilepsy with only focal onset epileptic seizures. Seizures can arise from a single location or multiple locations. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal epilepsy

Professional guidelines

PubMed

International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions.
Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer IE, Zuberi SM, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lim L, Naidoo A, Perucca E, Moshé SL, Wirrell EC, Tinuper P
Epilepsia 2022 Jun;63(6):1443-1474. Epub 2022 May 3 doi: 10.1111/epi.17240. PMID: 35503725
Medical treatment of Rasmussen's Encephalitis: A systematic review.
Lagarde S, Boucraut J, Bartolomei F
Rev Neurol (Paris) 2022 Sep;178(7):675-691. Epub 2022 Feb 4 doi: 10.1016/j.neurol.2022.01.007. PMID: 35131107
The management of epilepsy in children and adults.
Perucca P, Scheffer IE, Kiley M
Med J Aust 2018 Mar 19;208(5):226-233. doi: 10.5694/mja17.00951. PMID: 29540143

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.
Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Association of Dementia Risk With Focal Epilepsy and Modifiable Cardiovascular Risk Factors.
Tai XY, Torzillo E, Lyall DM, Manohar S, Husain M, Sen A
JAMA Neurol 2023 May 1;80(5):445-454. doi: 10.1001/jamaneurol.2023.0339. PMID: 36972059Free PMC Article
Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Adjunctive cenobamate in highly active and ultra-refractory focal epilepsy: A "real-world" retrospective study.
Peña-Ceballos J, Moloney PB, Munteanu T, Doyle M, Colleran N, Liggan B, Breen A, Murphy S, El-Naggar H, Widdess-Walsh P, Delanty N
Epilepsia 2023 May;64(5):1225-1235. Epub 2023 Feb 27 doi: 10.1111/epi.17549. PMID: 36790345
Electroclinical spectrum of generalized paroxysmal fast activity in adults without epileptic encephalopathy.
Das Pektezel L, Tezer FI, Saygi S
Neurol Sci 2022 Jun;43(6):3857-3866. Epub 2022 Jan 16 doi: 10.1007/s10072-021-05808-9. PMID: 35034232

Diagnosis

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.
Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
DEPDC5-related epilepsy: A comprehensive review.
Samanta D
Epilepsy Behav 2022 May;130:108678. Epub 2022 Apr 14 doi: 10.1016/j.yebeh.2022.108678. PMID: 35429726
Genetic Epilepsy Syndromes.
Myers KA
Continuum (Minneap Minn) 2022 Apr 1;28(2):339-362. doi: 10.1212/CON.0000000000001077. PMID: 35393962
Localisation in focal epilepsy: a practical guide.
Chowdhury FA, Silva R, Whatley B, Walker MC
Pract Neurol 2021 Dec;21(6):481-491. Epub 2021 Aug 17 doi: 10.1136/practneurol-2019-002341. PMID: 34404748
ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM
Epilepsia 2017 Apr;58(4):512-521. Epub 2017 Mar 8 doi: 10.1111/epi.13709. PMID: 28276062Free PMC Article

Therapy

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.
Bershteyn M, Bröer S, Parekh M, Maury Y, Havlicek S, Kriks S, Fuentealba L, Lee S, Zhou R, Subramanyam G, Sezan M, Sevilla ES, Blankenberger W, Spatazza J, Zhou L, Nethercott H, Traver D, Hampel P, Kim H, Watson M, Salter N, Nesterova A, Au W, Kriegstein A, Alvarez-Buylla A, Rubenstein J, Banik G, Bulfone A, Priest C, Nicholas CR
Cell Stem Cell 2023 Oct 5;30(10):1331-1350.e11. doi: 10.1016/j.stem.2023.08.013. PMID: 37802038Free PMC Article
Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.
Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Update on Antiseizure Medications 2022.
Abou-Khalil BW
Continuum (Minneap Minn) 2022 Apr 1;28(2):500-535. doi: 10.1212/CON.0000000000001104. PMID: 35393968
Antiseizure Medications for Adults With Epilepsy: A Review.
Kanner AM, Bicchi MM
JAMA 2022 Apr 5;327(13):1269-1281. doi: 10.1001/jama.2022.3880. PMID: 35380580
Seizure Cycles in Focal Epilepsy.
Leguia MG, Andrzejak RG, Rummel C, Fan JM, Mirro EA, Tcheng TK, Rao VR, Baud MO
JAMA Neurol 2021 Apr 1;78(4):454-463. doi: 10.1001/jamaneurol.2020.5370. PMID: 33555292Free PMC Article

Prognosis

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.
Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Genetic Epilepsy Syndromes.
Myers KA
Continuum (Minneap Minn) 2022 Apr 1;28(2):339-362. doi: 10.1212/CON.0000000000001077. PMID: 35393962
Incidence and Prevalence of Drug-Resistant Epilepsy: A Systematic Review and Meta-analysis.
Sultana B, Panzini MA, Veilleux Carpentier A, Comtois J, Rioux B, Gore G, Bauer PR, Kwon CS, Jetté N, Josephson CB, Keezer MR
Neurology 2021 Apr 27;96(17):805-817. Epub 2021 Mar 15 doi: 10.1212/WNL.0000000000011839. PMID: 33722992
Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment.
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article
Stroke-related epilepsy.
Feyissa AM, Hasan TF, Meschia JF
Eur J Neurol 2019 Jan;26(1):18-e3. Epub 2018 Oct 15 doi: 10.1111/ene.13813. PMID: 30320425

Clinical prediction guides

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.
Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Adjunctive Transdermal Cannabidiol for Adults With Focal Epilepsy: A Randomized Clinical Trial.
O'Brien TJ, Berkovic SF, French JA, Messenheimer JA, Sebree TB, Bonn-Miller MO, Gutterman DL; STAR 1/STAR 2 Study Group
JAMA Netw Open 2022 Jul 1;5(7):e2220189. doi: 10.1001/jamanetworkopen.2022.20189. PMID: 35802375Free PMC Article
Ictal crying.
Asadi-Pooya AA, Wyeth D, Sperling MR
Epilepsy Behav 2016 Jun;59:1-3. Epub 2016 Apr 13 doi: 10.1016/j.yebeh.2016.03.012. PMID: 27084975
Pediatric focal epilepsy syndromes.
Sánchez Fernández I, Loddenkemper T
J Clin Neurophysiol 2012 Oct;29(5):425-40. doi: 10.1097/WNP.0b013e31826bd943. PMID: 23027100

Recent systematic reviews

Efficacy and safety of six new antiseizure medications for adjunctive treatment of focal epilepsy and epileptic syndrome: A systematic review and network meta-analysis.
Tong J, Ji T, Liu T, Liu J, Chen Y, Li Z, Lu N, Li Q
Epilepsy Behav 2024 Mar;152:109653. Epub 2024 Jan 25 doi: 10.1016/j.yebeh.2024.109653. PMID: 38277848
Medical treatment of Rasmussen's Encephalitis: A systematic review.
Lagarde S, Boucraut J, Bartolomei F
Rev Neurol (Paris) 2022 Sep;178(7):675-691. Epub 2022 Feb 4 doi: 10.1016/j.neurol.2022.01.007. PMID: 35131107
Antidepressants for people with epilepsy and depression.
Maguire MJ, Marson AG, Nevitt SJ
Cochrane Database Syst Rev 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3. PMID: 33860531Free PMC Article
Incidence and Prevalence of Drug-Resistant Epilepsy: A Systematic Review and Meta-analysis.
Sultana B, Panzini MA, Veilleux Carpentier A, Comtois J, Rioux B, Gore G, Bauer PR, Kwon CS, Jetté N, Josephson CB, Keezer MR
Neurology 2021 Apr 27;96(17):805-817. Epub 2021 Mar 15 doi: 10.1212/WNL.0000000000011839. PMID: 33722992
Surgery for epilepsy.
West S, Nevitt SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2019 Jun 25;6(6):CD010541. doi: 10.1002/14651858.CD010541.pub3. PMID: 31237346Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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