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Optic Disc Edema

MedGen UID:
419265
•Concept ID:
C2930835
•
Disease or Syndrome

Definition

Swelling of the optic disc in the absence of increased intracranial pressure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOptic Disc Edema

Professional guidelines

PubMed

Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema.
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Dysthyroid optic neuropathy: evaluation and management.
Dolman PJ
J Endocrinol Invest 2021 Mar;44(3):421-429. Epub 2020 Jul 29 doi: 10.1007/s40618-020-01361-y. PMID: 32729049
ACR Appropriateness Criteria® Headache.
Expert Panel on Neurologic Imaging, Whitehead MT, Cardenas AM, Corey AS, Policeni B, Burns J, Chakraborty S, Crowley RW, Jabbour P, Ledbetter LN, Lee RK, Pannell JS, Pollock JM, Powers WJ, Setzen G, Shih RY, Subramaniam RM, Utukuri PS, Bykowski J
J Am Coll Radiol 2019 Nov;16(11S):S364-S377. doi: 10.1016/j.jacr.2019.05.030. PMID: 31685104

Recent clinical studies

Etiology

Dysthyroid Optic Neuropathy.
Potvin ARGG, Pakdel F, Saeed P
Ophthalmic Plast Reconstr Surg 2023 Dec 1;39(6S):S65-S80. Epub 2023 Dec 4 doi: 10.1097/IOP.0000000000002555. PMID: 38054987
Beyond Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies: Alternative Causes of Optic Neuritis.
Greco G, Colombo E, Gastaldi M, Ahmad L, Tavazzi E, Bergamaschi R, Rigoni E
Int J Mol Sci 2023 Nov 5;24(21) doi: 10.3390/ijms242115986. PMID: 37958968Free PMC Article
Approach to patient with unilateral optic disc edema and normal visual function.
Donaldson L, Margolin E
J Neurol Sci 2021 May 15;424:117414. Epub 2021 Mar 24 doi: 10.1016/j.jns.2021.117414. PMID: 33799215
Pediatric Uveitis.
Chan NS, Choi J, Cheung CMG
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):192-199. Epub 2018 Apr 23 doi: 10.22608/APO.2018116. PMID: 29682916
Optic disc edema from papilledema.
Zhang J, Foroozan R
Int Ophthalmol Clin 2014 Winter;54(1):13-26. doi: 10.1097/IIO.0000000000000006. PMID: 24296368

Diagnosis

Dysthyroid Optic Neuropathy.
Potvin ARGG, Pakdel F, Saeed P
Ophthalmic Plast Reconstr Surg 2023 Dec 1;39(6S):S65-S80. Epub 2023 Dec 4 doi: 10.1097/IOP.0000000000002555. PMID: 38054987
An update on optic neuritis.
Kraker JA, Chen JJ
J Neurol 2023 Oct;270(10):5113-5126. Epub 2023 Aug 5 doi: 10.1007/s00415-023-11920-x. PMID: 37542657
Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema.
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Neuroretinitis: a review.
Abdelhakim A, Rasool N
Curr Opin Ophthalmol 2018 Nov;29(6):514-519. doi: 10.1097/ICU.0000000000000527. PMID: 30148725
Pediatric Uveitis.
Chan NS, Choi J, Cheung CMG
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):192-199. Epub 2018 Apr 23 doi: 10.22608/APO.2018116. PMID: 29682916

Therapy

Dysthyroid Optic Neuropathy.
Potvin ARGG, Pakdel F, Saeed P
Ophthalmic Plast Reconstr Surg 2023 Dec 1;39(6S):S65-S80. Epub 2023 Dec 4 doi: 10.1097/IOP.0000000000002555. PMID: 38054987
A high-pressure situation.
Miller MJ, Hicks MJ, Foroozan R, Brodsky MC
Surv Ophthalmol 2023 Jul-Aug;68(4):815-820. Epub 2022 Aug 12 doi: 10.1016/j.survophthal.2022.08.001. PMID: 35970231
Space flight-associated neuro-ocular syndrome (SANS).
Lee AG, Mader TH, Gibson CR, Brunstetter TJ, Tarver WJ
Eye (Lond) 2018 Jul;32(7):1164-1167. Epub 2018 Mar 12 doi: 10.1038/s41433-018-0070-y. PMID: 29527011Free PMC Article
Space Flight-Associated Neuro-ocular Syndrome.
Lee AG, Mader TH, Gibson CR, Tarver W
JAMA Ophthalmol 2017 Sep 1;135(9):992-994. doi: 10.1001/jamaophthalmol.2017.2396. PMID: 28727859
Neuro-Ophthalmology of Space Flight.
Lee AG, Tarver WJ, Mader TH, Gibson CR, Hart SF, Otto CA
J Neuroophthalmol 2016 Mar;36(1):85-91. doi: 10.1097/WNO.0000000000000334. PMID: 26828842

Prognosis

Beyond Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies: Alternative Causes of Optic Neuritis.
Greco G, Colombo E, Gastaldi M, Ahmad L, Tavazzi E, Bergamaschi R, Rigoni E
Int J Mol Sci 2023 Nov 5;24(21) doi: 10.3390/ijms242115986. PMID: 37958968Free PMC Article
An update on optic neuritis.
Kraker JA, Chen JJ
J Neurol 2023 Oct;270(10):5113-5126. Epub 2023 Aug 5 doi: 10.1007/s00415-023-11920-x. PMID: 37542657
Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema.
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Neuroretinitis: a review.
Abdelhakim A, Rasool N
Curr Opin Ophthalmol 2018 Nov;29(6):514-519. doi: 10.1097/ICU.0000000000000527. PMID: 30148725
Astronaut ophthalmic syndrome.
Zwart SR, Gibson CR, Gregory JF, Mader TH, Stover PJ, Zeisel SH, Smith SM
FASEB J 2017 Sep;31(9):3746-3756. Epub 2017 May 25 doi: 10.1096/fj.201700294. PMID: 28546443

Clinical prediction guides

Unilateral optic disc drusen mis-diagnosed as optic neuritis: Diagnostic and therapeutic implications.
Bontzos G, Smoustopoulos G, Detorakis TE
Rom J Ophthalmol 2020 Oct-Dec;64(4):449-454. doi: 10.22336/rjo.2020.69. PMID: 33367185Free PMC Article
The escape of retrobulbar cerebrospinal fluid in the astronaut's eye: mission impossible?
Wostyn P, Mader TH, Gibson CR, Killer HE
Eye (Lond) 2019 Oct;33(10):1519-1524. Epub 2019 May 7 doi: 10.1038/s41433-019-0453-8. PMID: 31065103Free PMC Article
Optic Disc Edema in Glial Fibrillary Acidic Protein Autoantibody-Positive Meningoencephalitis.
Chen JJ, Aksamit AJ, McKeon A, Pittock SJ, Weinshenker BG, Leavitt JA, Morris PP, Flanagan EP
J Neuroophthalmol 2018 Sep;38(3):276-281. doi: 10.1097/WNO.0000000000000593. PMID: 29210929
Astronaut ophthalmic syndrome.
Zwart SR, Gibson CR, Gregory JF, Mader TH, Stover PJ, Zeisel SH, Smith SM
FASEB J 2017 Sep;31(9):3746-3756. Epub 2017 May 25 doi: 10.1096/fj.201700294. PMID: 28546443
Neuro-Ophthalmology of Space Flight.
Lee AG, Tarver WJ, Mader TH, Gibson CR, Hart SF, Otto CA
J Neuroophthalmol 2016 Mar;36(1):85-91. doi: 10.1097/WNO.0000000000000334. PMID: 26828842

Recent systematic reviews

Visual System Involvement in Glial Fibrillary Acidic Protein Astrocytopathy: Two Case Reports and a Systematic Literature Review.
Greco G, Masciocchi S, Diamanti L, Bini P, Vegezzi E, Marchioni E, Colombo E, Rigoni E, Businaro P, Ferraro OE, Bianchi Marzoli S, Bergamaschi R, Franciotta D, Gastaldi M
Neurol Neuroimmunol Neuroinflamm 2023 Sep;10(5) Epub 2023 Aug 15 doi: 10.1212/NXI.0000000000200146. PMID: 37582612Free PMC Article
Inappropriate Indexing of Case Reports to the "Papilledema" Subject Heading: A Systematic Review.
Tao BK, Vosoughi AR, Pandya BU, Ishaq J, Margolin EA, Micieli JA
J Neuroophthalmol 2023 Dec 1;43(4):525-530. Epub 2023 Jun 12 doi: 10.1097/WNO.0000000000001895. PMID: 37307081
Inappropriate Use of the Term "Papilledema" in the Medical Literature: A Systematic Review of Case Reports across Specialties.
Tao B, Vosoughi A, Margolin E, Micieli JA
Ophthalmology 2023 Feb;130(2):129-136. Epub 2022 Oct 3 doi: 10.1016/j.ophtha.2022.09.017. PMID: 36195254
Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review.
Lotan I, Lydston M, Levy M
J Neuroophthalmol 2022 Jun 1;42(2):154-162. Epub 2022 Mar 25 doi: 10.1097/WNO.0000000000001537. PMID: 35427282
Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review.
Song JH, Koreishi AF, Goldstein DA
Ocul Immunol Inflamm 2019;27(6):998-1009. Epub 2018 Jul 3 doi: 10.1080/09273948.2018.1485958. PMID: 29969330

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