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Furunculosis

MedGen UID:
42118
•Concept ID:
C0016867
•
Disease or Syndrome

Definition

A skin condition that is characterized by recurring furuncles, lesions primarily caused by staphylococcus aureus infection of the hair follicles and surrounding skin. Furunculosis occurs more frequently in persons with immune systems disorders than in the general population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFurunculosis

Professional guidelines

PubMed

Treatment of recurrent staphylococcal furunculosis.
Sweetman L, Ellis-Pegler RB
Med J Aust 1992 Feb 17;156(4):292. doi: 10.5694/j.1326-5377.1992.tb139762.x. PMID: 1738340
THE TREATMENT OF STAPHYLOCOCCAL INFECTIONS.
KOENIG MG
Med Clin North Am 1963 Sep;47:1231-45. doi: 10.1016/s0025-7125(16)33530-1. PMID: 14062090
Cajeput-type oil for the treatment of furunculosis.
FEINBLATT HM
J Natl Med Assoc 1960 Jan;52(1):32-4. PMID: 13821941Free PMC Article

Recent clinical studies

Etiology

Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Follicular occlusion disorders in Down syndrome patients.
Firsowicz M, Boyd M, Jacks SK
Pediatr Dermatol 2020 Jan;37(1):219-221. Epub 2019 Oct 18 doi: 10.1111/pde.14012. PMID: 31626333
Management of extrapulmonary nontuberculous mycobacterial infections.
Kasperbauer S, Huitt G
Semin Respir Crit Care Med 2013 Feb;34(1):143-50. Epub 2013 Mar 4 doi: 10.1055/s-0033-1333576. PMID: 23460014
Erythema ab igne.
Miller K, Hunt R, Chu J, Meehan S, Stein J
Dermatol Online J 2011 Oct 15;17(10):28. PMID: 22031654
Common bacterial skin infections.
Trent JT, Federman D, Kirsner RS
Ostomy Wound Manage 2001 Aug;47(8):30-4. PMID: 11890001

Diagnosis

Severe bacterial skin infections.
Marques SA, Abbade LPF
An Bras Dermatol 2020 Jul-Aug;95(4):407-417. Epub 2020 May 16 doi: 10.1016/j.abd.2020.04.003. PMID: 32507327Free PMC Article
Erythema ab igne.
Miller K, Hunt R, Chu J, Meehan S, Stein J
Dermatol Online J 2011 Oct 15;17(10):28. PMID: 22031654
Smoker's boils.
Happle R, König A
Dermatology 2011;222(3):282-4. Epub 2011 May 26 doi: 10.1159/000327923. PMID: 21613779
Furunculosis.
Chan KL, Soo G, van Hasselt CA
Ear Nose Throat J 1997 Mar;76(3):126. PMID: 9086637
Furuncular myiasis.
Iannini PB, Brandt D, LaForce M
JAMA 1975 Sep 29;233(13):1375-6. doi: 10.1001/jama.233.13.1375. PMID: 1174211

Therapy

Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Erythema ab igne.
Miller K, Hunt R, Chu J, Meehan S, Stein J
Dermatol Online J 2011 Oct 15;17(10):28. PMID: 22031654
Smoker's boils.
Happle R, König A
Dermatology 2011;222(3):282-4. Epub 2011 May 26 doi: 10.1159/000327923. PMID: 21613779
Hidradenitis suppurativa.
Brown TJ, Rosen T, Orengo IF
South Med J 1998 Dec;91(12):1107-14. doi: 10.1097/00007611-199812000-00003. PMID: 9853721
Furunculosis.
Chan KL, Soo G, van Hasselt CA
Ear Nose Throat J 1997 Mar;76(3):126. PMID: 9086637

Prognosis

Management of extrapulmonary nontuberculous mycobacterial infections.
Kasperbauer S, Huitt G
Semin Respir Crit Care Med 2013 Feb;34(1):143-50. Epub 2013 Mar 4 doi: 10.1055/s-0033-1333576. PMID: 23460014
Erythema ab igne.
Miller K, Hunt R, Chu J, Meehan S, Stein J
Dermatol Online J 2011 Oct 15;17(10):28. PMID: 22031654
Obesity and dermatology.
Scheinfeld NS
Clin Dermatol 2004 Jul-Aug;22(4):303-9. doi: 10.1016/j.clindermatol.2004.01.001. PMID: 15475230
Hidradenitis suppurativa.
Brown TJ, Rosen T, Orengo IF
South Med J 1998 Dec;91(12):1107-14. doi: 10.1097/00007611-199812000-00003. PMID: 9853721
Furuncular cuterebrid myiasis.
Shorter N, Werninghaus K, Mooney D, Graham A
J Pediatr Surg 1997 Oct;32(10):1511-3. doi: 10.1016/s0022-3468(97)90579-0. PMID: 9349786

Clinical prediction guides

Cutaneous infections in the mature patient.
Castro MCR, Ramos-E-Silva M
Clin Dermatol 2018 Mar-Apr;36(2):188-196. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.010. PMID: 29566923
Screening of differentially expressed genes in pathological scar tissues using expression microarray.
Huang LP, Mao Z, Zhang L, Liu XX, Huang C, Jia ZS
Genet Mol Res 2015 Sep 9;14(3):10743-51. doi: 10.4238/2015.September.9.13. PMID: 26400303
Treatment and prevention of recurrent staphylococcal furunculosis: clinical and bacteriological follow-up.
Hedström SA
Scand J Infect Dis 1985;17(1):55-8. doi: 10.3109/00365548509070420. PMID: 3992206
Dicloxacillin and flucloxacillin twice daily with probenecid in staphylococcal infections. A clinical and pharmakokinetic evaluation.
Hedström SA, Kahlmeter G
Scand J Infect Dis 1980;12(3):221-5. doi: 10.3109/inf.1980.12.issue-3.10. PMID: 7433922
Furuncle.
Pinkus H
J Cutan Pathol 1979 Dec;6(6):517-8. doi: 10.1111/j.1600-0560.1979.tb01181.x. PMID: 521543

Recent systematic reviews

Nasal Vestibulitis and Vestibular Furunculosis: a systematic review about two common nasal infections and considerations about correct diagnosis and management.
Marra P, Colacurcio V, De Luca P, Bisogno A, Calvanese M, Scarpa A, Ralli M, De Vincentiis M, Camaioni A, Salzano FA
Clin Ter 2022 Nov-Dec;173(6):590-596. doi: 10.7417/CT.2022.2487. PMID: 36373460
Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Association between prior antibiotic therapy and subsequent risk of community-acquired infections: a systematic review.
Malik U, Armstrong D, Ashworth M, Dregan A, L'Esperance V, McDonnell L, Molokhia M, White P
J Antimicrob Chemother 2018 Feb 1;73(2):287-296. doi: 10.1093/jac/dkx374. PMID: 29149266
Interventions for acute otitis externa.
Kaushik V, Malik T, Saeed SR
Cochrane Database Syst Rev 2010 Jan 20;(1):CD004740. doi: 10.1002/14651858.CD004740.pub2. PMID: 20091565

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