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Hyperplasia of prostate

MedGen UID:
422472
•Concept ID:
C2937421
•
Pathologic Function
Synonyms: Hyperplasia, Prostatic; Prostatic Hyperplasia
SNOMED CT: Hyperplasia of prostate (433234005)

Definition

Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperplasia of prostate

Professional guidelines

PubMed

1470 nm laser is better for prostate hyperplasia treatment with different volume size via transurethral enucleation.
Fayou Z, Jiude Z, Shuxian Z, Yajun S, Wei X, Jia Y, Fan S, Yueling X, Renrui H, Xiaolei T
BMC Surg 2023 Nov 21;23(1):356. doi: 10.1186/s12893-023-02266-2. PMID: 37990316Free PMC Article
Increased consultation frequency in primary care, a risk marker for cancer: a case-control study.
Ewing M, Naredi P, Nemes S, Zhang C, Månsson J
Scand J Prim Health Care 2016 Jun;34(2):205-12. Epub 2016 May 18 doi: 10.1080/02813432.2016.1183692. PMID: 27189513Free PMC Article
Current status of 5alpha-reductase inhibitors in the treatment of benign hyperplasia of prostate.
Kumar VL, Wahane VD
Indian J Med Sci 2008 Apr;62(4):167-75. PMID: 18445985

Recent clinical studies

Etiology

Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation.
Fang C, Wu L, Zhao MJ, Deng T, Gu JM, Guo XP, Li C, Li W, Zeng XT
Oxid Med Cell Longev 2021;2021:2094665. Epub 2021 Oct 18 doi: 10.1155/2021/2094665. PMID: 34707774Free PMC Article
Histomorphological study of prostatic adenocarcinoma and its mimics.
Mahapatra QS, Mohanty P, Nanda A, Mohanty L
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):251-260. doi: 10.4103/IJPM.IJPM_322_18. PMID: 30971549
Establishment and Validation of Extra-transitional Zone Prostate Specific Antigen Density (ETzD), a Novel Structure-based Parameter for Quantifying the Oncological Hazard of Prostates with Enlarged Stroma.
Kim JJ, Suh YS, Kim TH, Jeon SS, Lee HM, Choi HY, Kim S, Lee KS
Sci Rep 2019 Jan 25;9(1):770. doi: 10.1038/s41598-018-36602-x. PMID: 30683879Free PMC Article
CD10 expression pattern in prostatic adenocarcinoma: Elucidation of differences between Gleason's grades.
Kaur M, Verma S, Gupta R, Pant L, Singh S
Malays J Pathol 2018 Apr;40(1):57-60. PMID: 29704385
Increased consultation frequency in primary care, a risk marker for cancer: a case-control study.
Ewing M, Naredi P, Nemes S, Zhang C, Månsson J
Scand J Prim Health Care 2016 Jun;34(2):205-12. Epub 2016 May 18 doi: 10.1080/02813432.2016.1183692. PMID: 27189513Free PMC Article

Diagnosis

Histomorphological study of prostatic adenocarcinoma and its mimics.
Mahapatra QS, Mohanty P, Nanda A, Mohanty L
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):251-260. doi: 10.4103/IJPM.IJPM_322_18. PMID: 30971549
Establishment and Validation of Extra-transitional Zone Prostate Specific Antigen Density (ETzD), a Novel Structure-based Parameter for Quantifying the Oncological Hazard of Prostates with Enlarged Stroma.
Kim JJ, Suh YS, Kim TH, Jeon SS, Lee HM, Choi HY, Kim S, Lee KS
Sci Rep 2019 Jan 25;9(1):770. doi: 10.1038/s41598-018-36602-x. PMID: 30683879Free PMC Article
A hybrid particle swarm and neural network approach for detection of prostate cancer from benign hyperplasia of prostate.
Sadoughi F, Ghaderzadeh M
Stud Health Technol Inform 2014;205:481-5. PMID: 25160231
Basal cell hyperplasia of prostate: an elusive lesion?
Golomb J, Lewin KJ
Urology 1992 Sep;40(3):245-8. doi: 10.1016/0090-4295(92)90483-d. PMID: 1381852
Clear cell cribriform hyperplasia of prostate. Report of 10 cases.
Ayala AG, Srigley JR, Ro JY, Abdul-Karim FW, Johnson DE
Am J Surg Pathol 1986 Oct;10(10):665-71. doi: 10.1097/00000478-198610000-00001. PMID: 3766845

Therapy

Current status of 5alpha-reductase inhibitors in the treatment of benign hyperplasia of prostate.
Kumar VL, Wahane VD
Indian J Med Sci 2008 Apr;62(4):167-75. PMID: 18445985
The behavior of prostate specific antigen (PSA) and free-PSA (f-PSA) under antihormonal therapy.
Wechsel HW, Gleichmann R, Blasseneck J
Anticancer Res 2000 Nov-Dec;20(6D):4993-4. PMID: 11326655

Prognosis

Establishment and Validation of Extra-transitional Zone Prostate Specific Antigen Density (ETzD), a Novel Structure-based Parameter for Quantifying the Oncological Hazard of Prostates with Enlarged Stroma.
Kim JJ, Suh YS, Kim TH, Jeon SS, Lee HM, Choi HY, Kim S, Lee KS
Sci Rep 2019 Jan 25;9(1):770. doi: 10.1038/s41598-018-36602-x. PMID: 30683879Free PMC Article
Overexpression of Cdc20 in clinically localized prostate cancer: Relation to high Gleason score and biochemical recurrence after laparoscopic radical prostatectomy.
Mao Y, Li K, Lu L, Si-Tu J, Lu M, Gao X
Cancer Biomark 2016;16(3):351-8. doi: 10.3233/CBM-160573. PMID: 26889981
A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia.
Basu S, Majumder S, Bhowal A, Ghosh A, Naskar S, Nandy S, Mukherjee S, Sinha RK, Basu K, Karmakar D, Banerjee S, Sengupta S
PLoS One 2015;10(5):e0125560. Epub 2015 May 4 doi: 10.1371/journal.pone.0125560. PMID: 25938433Free PMC Article
Comparative study of total prostate specific antigen and free to total prostate specific antigen ratio in the diagnosis of prostate cancer.
Chakraborty L, Ahmed AN, Paul BK, Haque A, Ara A, Nabi S, Nessa M
Mymensingh Med J 2012 Jan;21(1):98-102. PMID: 22314462
Case report: Malignant phyllodes tumor of prostate.
Agrawal V, Sharma D, Wadhwa N
Int Urol Nephrol 2003;35(1):37-9. doi: 10.1023/a:1025906715819. PMID: 14620281

Clinical prediction guides

Establishment and Validation of Extra-transitional Zone Prostate Specific Antigen Density (ETzD), a Novel Structure-based Parameter for Quantifying the Oncological Hazard of Prostates with Enlarged Stroma.
Kim JJ, Suh YS, Kim TH, Jeon SS, Lee HM, Choi HY, Kim S, Lee KS
Sci Rep 2019 Jan 25;9(1):770. doi: 10.1038/s41598-018-36602-x. PMID: 30683879Free PMC Article
Overexpression of Cdc20 in clinically localized prostate cancer: Relation to high Gleason score and biochemical recurrence after laparoscopic radical prostatectomy.
Mao Y, Li K, Lu L, Si-Tu J, Lu M, Gao X
Cancer Biomark 2016;16(3):351-8. doi: 10.3233/CBM-160573. PMID: 26889981
A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia.
Basu S, Majumder S, Bhowal A, Ghosh A, Naskar S, Nandy S, Mukherjee S, Sinha RK, Basu K, Karmakar D, Banerjee S, Sengupta S
PLoS One 2015;10(5):e0125560. Epub 2015 May 4 doi: 10.1371/journal.pone.0125560. PMID: 25938433Free PMC Article
Comparative study of total prostate specific antigen and free to total prostate specific antigen ratio in the diagnosis of prostate cancer.
Chakraborty L, Ahmed AN, Paul BK, Haque A, Ara A, Nabi S, Nessa M
Mymensingh Med J 2012 Jan;21(1):98-102. PMID: 22314462
A novel 21-kDa protein as a serum marker for benign and malignant urogenital tumors: preliminary communication.
Shalitin C, Epelbaum R, Valansi C, Segal R, Mekori T, Lover B, Robinson E
Int J Cancer 1991 Dec 2;49(6):861-6. doi: 10.1002/ijc.2910490610. PMID: 1959989

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