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Spinal cord glioma

MedGen UID:
423646
•Concept ID:
C2937245
•
Neoplastic Process
Synonyms: Glial Neoplasm Spinal Cord; glial neoplasm spinal cord; Glial tumor of spinal cord; Glial Tumor of Spinal Cord; glial tumor of spinal cord; glial tumour of spinal cord; Glioma of spinal cord; glioma of spinal cord; malignant glioma of spinal cord; Spinal Cord Glial Neoplasm; spinal cord glial neoplasm; Spinal Cord Glial Tumor; spinal cord glial tumor; spinal cord glial tumour; Spinal Cord Glioma; spinal cord glioma; spinal cord malignant glioma
SNOMED CT: Glial tumor of spinal cord (254946004); Glioma of spinal cord (254947008)
 
Monarch Initiative: MONDO:0002542

Definition

A neoplasm that arises from glial cells in the spinal cord. Representative examples include astrocytoma, oligodendroglioma, and ependymoma. [from NCI]

Professional guidelines

PubMed

Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
Treatment outcomes of radiotherapy for primary spinal cord glioma.
Choi SH, Yoon HI, Yi S, Park JW, Cho J, Shin DA, Ha Y, Kim DS, Kim SH, Lee SK, Chang JH, Suh CO
Strahlenther Onkol 2019 Feb;195(2):164-174. Epub 2018 Sep 10 doi: 10.1007/s00066-018-1366-3. PMID: 30203111
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells.
Ropper AE, Zeng X, Haragopal H, Anderson JE, Aljuboori Z, Han I, Abd-El-Barr M, Lee HJ, Sidman RL, Snyder EY, Viapiano MS, Kim SU, Chi JH, Teng YD
Neurosurgery 2016 Sep;79(3):481-91. doi: 10.1227/NEU.0000000000001174. PMID: 26671631

Recent clinical studies

Etiology

Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Tumor microenvironment in a minipig model of spinal cord glioma.
Tora MS, Neill SG, Lakhina Y, Assed H, Zhang M, Nagarajan PP, Federici T, Gutierrez J, Hoang KB, Du Y, Lei K, Boulis NM
J Transl Med 2023 Sep 27;21(1):667. doi: 10.1186/s12967-023-04531-7. PMID: 37752585Free PMC Article
Contrast-Enhanced Ultrasound in Resection of Spinal Cord Gliomas.
Han B, Zhang L, Jia W
World Neurosurg 2023 Mar;171:e83-e92. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.087. PMID: 36427693
Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194

Diagnosis

Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ
Brain Pathol 2023 Jul;33(4):e13153. Epub 2023 Feb 7 doi: 10.1111/bpa.13153. PMID: 36751054Free PMC Article
Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Spinal cord glioma metastasizing to the brain.
Saidha S, Pardo CA
Arch Neurol 2012 Aug;69(8):1078-9. doi: 10.1001/archneurol.2012.8. PMID: 22529250
MRI of radiation induced spinal cord glioma.
Bazan C 3rd, New PZ, Kagan-Hallet KS
Neuroradiology 1990;32(4):331-3. doi: 10.1007/BF00593057. PMID: 2234396

Therapy

Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs.
Tora MS, Texakalidis P, Neill S, Wetzel J, Rindler RS, Hardcastle N, Nagarajan PP, Krasnopeyev A, Roach C, James R, Bruce JN, Canoll P, Federici T, Oshinski JN, Boulis NM
Sci Rep 2020 Mar 24;10(1):5291. doi: 10.1038/s41598-020-62167-9. PMID: 32210315Free PMC Article
MRI of radiation induced spinal cord glioma.
Bazan C 3rd, New PZ, Kagan-Hallet KS
Neuroradiology 1990;32(4):331-3. doi: 10.1007/BF00593057. PMID: 2234396
Spinal cord glioma after multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis: case report.
Steinbok P
J Neurosurg 1980 Jun;52(6):838-41. doi: 10.3171/jns.1980.52.6.0838. PMID: 7381543
Spinal cord glioma following irradiation for Hodgkin's disease.
Clifton MD, Amromin GD, Perry MC, Abadir R, Watts C, Levy N
Cancer 1980 Apr 15;45(8):2051-5. doi: 10.1002/1097-0142(19800415)45:8<2051::aid-cncr2820450811>3.0.co;2-3. PMID: 7370950

Prognosis

Primary spinal cord gliomas: Pathologic features associated with prognosis.
Tanaka Y, Natsumeda M, Ohashi M, Saito R, Higa N, Akahane T, Hashidate H, Ito J, Fujii S, Sasaki A, Tanimoto A, Hanaya R, Watanabe K, Oishi M, Kawashima H, Kakita A
J Neuropathol Exp Neurol 2024 Dec 1;83(12):1010-1019. doi: 10.1093/jnen/nlae084. PMID: 39074166
Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ
Brain Pathol 2023 Jul;33(4):e13153. Epub 2023 Feb 7 doi: 10.1111/bpa.13153. PMID: 36751054Free PMC Article
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Spinal cord glioma metastasizing to the brain.
Saidha S, Pardo CA
Arch Neurol 2012 Aug;69(8):1078-9. doi: 10.1001/archneurol.2012.8. PMID: 22529250

Clinical prediction guides

Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway.
Zhao Z, Song Z, Wang Z, Zhang F, Ding Z, Zhao Z, Liu L, Fan T
Int J Immunopathol Pharmacol 2024 Jan-Dec;38:3946320241276336. doi: 10.1177/03946320241276336. PMID: 39180753Free PMC Article
Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Contrast-Enhanced Ultrasound in Resection of Spinal Cord Gliomas.
Han B, Zhang L, Jia W
World Neurosurg 2023 Mar;171:e83-e92. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.087. PMID: 36427693
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres.
Hsu W, Siu IM, Pradilla G, Gokaslan ZL, Jallo GI, Gallia GL
J Neurosurg Spine 2012 Mar;16(3):315-9. Epub 2011 Dec 23 doi: 10.3171/2011.11.SPINE11492. PMID: 22195609

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