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Histoplasmosis

MedGen UID:
42468
•Concept ID:
C0019655
•
Disease or Syndrome
Synonyms: Histoplasma Infection; Histoplasma Infections; Infection, Histoplasma
SNOMED CT: Histoplasmosis (12962009)
 
HPO: HP:0032256
Monarch Initiative: MONDO:0018312
Orphanet: ORPHA390

Definition

Histoplasmosis is caused by the fungus Histoplasma capsulatum and is consider to be an opportunistic infection in immunosuppressed persons. [from HPO]

Conditions with this feature

Immunodeficiency 117
MedGen UID:
1848763
•Concept ID:
C5882739
•
Disease or Syndrome
Immunodeficiency-117 (IMD117) is an autosomal recessive immunologic disorder characterized by increased susceptibility to disseminated mycobacterial infection apparent in early childhood. Affected individuals develop mycobacterial disease after BCG (bacille Calmette-Guerin) vaccination and show increased susceptibility to other mycobacterial infections, such as M. avium. Immunologic workup shows impaired development of myeloid and lymphoid cell subsets that secrete and respond to gamma-interferon (IFNG; 147570) (et al., 2023).
See: Condition Record
Immunodeficiency 117

Professional guidelines

PubMed

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes.
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA
Semin Respir Crit Care Med 2020 Feb;41(1):13-30. Epub 2020 Jan 30 doi: 10.1055/s-0039-1698429. PMID: 32000281
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785

Recent clinical studies

Etiology

The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era.
Mazi PB, Sahrmann JM, Olsen MA, Coler-Reilly A, Rauseo AM, Pullen M, Zuniga-Moya JC, Powderly WG, Spec A
Clin Infect Dis 2023 Apr 3;76(7):1295-1301. doi: 10.1093/cid/ciac882. PMID: 36366776Free PMC Article
Pulmonary Histoplasmosis.
Tobón AM, Gómez BL
Mycopathologia 2021 Oct;186(5):697-705. Epub 2021 Sep 8 doi: 10.1007/s11046-021-00588-4. PMID: 34498137
Clinical Perspectives in the Diagnosis and Management of Histoplasmosis.
Azar MM, Hage CA
Clin Chest Med 2017 Sep;38(3):403-415. Epub 2017 May 17 doi: 10.1016/j.ccm.2017.04.004. PMID: 28797485
Presumed ocular histoplasmosis.
Thuruthumaly C, Yee DC, Rao PK
Curr Opin Ophthalmol 2014 Nov;25(6):508-12. doi: 10.1097/ICU.0000000000000100. PMID: 25237930
Pulmonary histoplasmosis.
McKinsey DS, McKinsey JP
Semin Respir Crit Care Med 2011 Dec;32(6):735-44. Epub 2011 Dec 13 doi: 10.1055/s-0031-1295721. PMID: 22167401

Diagnosis

Coccidioidomycosis and Histoplasmosis in Immunocompetent Persons.
Galgiani JN, Kauffman CA
N Engl J Med 2024 Feb 8;390(6):536-547. doi: 10.1056/NEJMra2306821. PMID: 38324487
Pulmonary Histoplasmosis.
Tobón AM, Gómez BL
Mycopathologia 2021 Oct;186(5):697-705. Epub 2021 Sep 8 doi: 10.1007/s11046-021-00588-4. PMID: 34498137
Histoplasmosis.
Araúz AB, Papineni P
Infect Dis Clin North Am 2021 Jun;35(2):471-491. doi: 10.1016/j.idc.2021.03.011. PMID: 34016287
Histoplasmosis.
Wheat LJ, Azar MM, Bahr NC, Spec A, Relich RF, Hage C
Infect Dis Clin North Am 2016 Mar;30(1):207-27. doi: 10.1016/j.idc.2015.10.009. PMID: 26897068
Histoplasmosis.
Kauffman CA
Clin Chest Med 2009 Jun;30(2):217-25, v. doi: 10.1016/j.ccm.2009.02.002. PMID: 19375629

Therapy

Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes.
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA
Semin Respir Crit Care Med 2020 Feb;41(1):13-30. Epub 2020 Jan 30 doi: 10.1055/s-0039-1698429. PMID: 32000281
Histoplasmosis.
Wheat LJ, Azar MM, Bahr NC, Spec A, Relich RF, Hage C
Infect Dis Clin North Am 2016 Mar;30(1):207-27. doi: 10.1016/j.idc.2015.10.009. PMID: 26897068
Ocular neovascularization.
Campochiaro PA
J Mol Med (Berl) 2013 Mar;91(3):311-21. Epub 2013 Jan 18 doi: 10.1007/s00109-013-0993-5. PMID: 23329331Free PMC Article
Pulmonary histoplasmosis.
Hage CA, Wheat LJ, Loyd J, Allen SD, Blue D, Knox KS
Semin Respir Crit Care Med 2008 Apr;29(2):151-65. doi: 10.1055/s-2008-1063854. PMID: 18365997
Intravenous itraconazole.
Slain D, Rogers PD, Cleary JD, Chapman SW
Ann Pharmacother 2001 Jun;35(6):720-9. doi: 10.1345/aph.10262. PMID: 11408991

Prognosis

Disseminated Histoplasmosis.
Sevestre J, Hasseine L
N Engl J Med 2019 Mar 14;380(11):e13. doi: 10.1056/NEJMicm1809792. PMID: 30865801
Mapping Histoplasma capsulatum Exposure, United States.
Maiga AW, Deppen S, Scaffidi BK, Baddley J, Aldrich MC, Dittus RS, Grogan EL
Emerg Infect Dis 2018 Oct;24(10):1835-1839. doi: 10.3201/eid2410.180032. PMID: 30226187Free PMC Article
Histoplasmosis in transplant recipients.
Gajurel K, Dhakal R, Deresinski S
Clin Transplant 2017 Oct;31(10) Epub 2017 Sep 5 doi: 10.1111/ctr.13087. PMID: 28805270
Fungal infections in HIV/AIDS.
Limper AH, Adenis A, Le T, Harrison TS
Lancet Infect Dis 2017 Nov;17(11):e334-e343. Epub 2017 Jul 31 doi: 10.1016/S1473-3099(17)30303-1. PMID: 28774701
Cutaneous histoplasmosis in renal transplant recipients.
Sun NZ, Augustine JJ, Gerstenblith MR
Clin Transplant 2014 Oct;28(10):1069-74. Epub 2014 Jul 17 doi: 10.1111/ctr.12409. PMID: 24961319

Clinical prediction guides

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.
Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, Degar B, Garrington TP, Sevilla J, Putti MC, Fagioli F, Ahlmann M, Dapena Diaz JL, Henry M, De Benedetti F, Grom A, Lapeyre G, Jacqmin P, Ballabio M, de Min C
N Engl J Med 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326. PMID: 32374962
Broncholithiasis: A Review.
Alshabani K, Ghosh S, Arrossi AV, Mehta AC
Chest 2019 Sep;156(3):445-455. Epub 2019 Jun 4 doi: 10.1016/j.chest.2019.05.012. PMID: 31173766
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.
Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL
JAMA Neurol 2018 Aug 1;75(8):947-955. doi: 10.1001/jamaneurol.2018.0463. PMID: 29710329Free PMC Article
Histoplasma capsulatum, lung infection and immunity.
Horwath MC, Fecher RA, Deepe GS Jr
Future Microbiol 2015;10(6):967-75. doi: 10.2217/fmb.15.25. PMID: 26059620Free PMC Article
Paramacular coloboma.
Pian D, Ferrucci S, Anderson SF, Wu C
Optom Vis Sci 2003 Aug;80(8):556-63. doi: 10.1097/00006324-200308000-00008. PMID: 12917574

Recent systematic reviews

Epidemiological, clinical, diagnostic, and therapeutic features of histoplasmosis: A systematic review.
Zida A, Guiguemdé TK, Sawadogo MP, Tchekounou C, Sangaré I, Bamba S
J Mycol Med 2024 Jun;34(2):101474. Epub 2024 Mar 11 doi: 10.1016/j.mycmed.2024.101474. PMID: 38484562
Current epidemiology of histoplasmosis in Nigeria: A systematic review and meta-analysis.
Ekeng BE, Davies AA, Osaigbovo II, Emanghe UE, Udoh UA, Alex-Wele MA, Adereti OC, Oladele RO
Niger Postgrad Med J 2023 Jan-Mar;30(1):12-17. doi: 10.4103/npmj.npmj_311_22. PMID: 36814158
Risk-Based Estimate of Human Fungal Disease Burden, China.
Zhou LH, Jiang YK, Li RY, Huang LP, Yip CW, Denning DW, Zhu LP
Emerg Infect Dis 2020 Sep;26(9):2137-2147. doi: 10.3201/eid2609.200016. PMID: 32818410Free PMC Article
The use of genetic markers in the molecular epidemiology of histoplasmosis: a systematic review.
Damasceno LS, Leitão TM, Taylor ML, Muniz MM, Zancopé-Oliveira RM
Eur J Clin Microbiol Infect Dis 2016 Jan;35(1):19-27. Epub 2015 Nov 20 doi: 10.1007/s10096-015-2508-5. PMID: 26589702
Transcatheter heart valve failure: a systematic review.
Mylotte D, Andalib A, Thériault-Lauzier P, Dorfmeister M, Girgis M, Alharbi W, Chetrit M, Galatas C, Mamane S, Sebag I, Buithieu J, Bilodeau L, de Varennes B, Lachapelle K, Lange R, Martucci G, Virmani R, Piazza N
Eur Heart J 2015 Jun 1;36(21):1306-27. Epub 2014 Sep 28 doi: 10.1093/eurheartj/ehu388. PMID: 25265974

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