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Bacterial vaginosis

MedGen UID:
43118
Concept ID:
C0085166
Disease or Syndrome
Synonyms: Bacterial Vaginitides; Bacterial Vaginitis; Bacterial Vaginoses; Bacterial Vaginosis; Nonspecific Vaginitis; Vaginitides, Bacterial; Vaginitis, Bacterial; Vaginitis, Nonspecific; Vaginoses, Bacterial; Vaginosis, Bacterial
SNOMED CT: Bacterial vaginosis (419760006); BV - Bacterial vaginosis (419760006); Bacterial vaginitis (419760006); Nonspecific bacterial vaginosis (419760006)
 
Monarch Initiative: MONDO:0005316

Definition

Infection caused by bacterial overgrowth in the vagina. Most affected women are asymptomatic. When symptoms occur, they include foul-smelling vaginal discharge, vaginal itching, and burning. Risk factors include sexual activity with multiple partners and the use of vaginal douches and intrauterine devices. Up to a third of cases resolve without treatment. Antibiotic treatment is recommended when symptoms are present and for women that are pregnant at the time of infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBacterial vaginosis

Professional guidelines

PubMed

Marnach ML, Wygant JN, Casey PM
Mayo Clin Proc 2022 Feb;97(2):347-358. doi: 10.1016/j.mayocp.2021.09.022. PMID: 35120697
Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, Reno H, Zenilman JM, Bolan GA
MMWR Recomm Rep 2021 Jul 23;70(4):1-187. doi: 10.15585/mmwr.rr7004a1. PMID: 34292926Free PMC Article
Curry A, Williams T, Penny ML
Am Fam Physician 2019 Sep 15;100(6):357-364. PMID: 31524362

Recent clinical studies

Etiology

Shroff S
Med Clin North Am 2023 Mar;107(2):299-315. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.009. PMID: 36759099
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Saraf VS, Sheikh SA, Ahmad A, Gillevet PM, Bokhari H, Javed S
Arch Microbiol 2021 Sep;203(7):3793-3802. Epub 2021 Jun 13 doi: 10.1007/s00203-021-02414-3. PMID: 34120200
Ravel J, Moreno I, Simón C
Am J Obstet Gynecol 2021 Mar;224(3):251-257. Epub 2020 Oct 19 doi: 10.1016/j.ajog.2020.10.019. PMID: 33091407
Coudray MS, Madhivanan P
Eur J Obstet Gynecol Reprod Biol 2020 Feb;245:143-148. Epub 2019 Dec 24 doi: 10.1016/j.ejogrb.2019.12.035. PMID: 31901667Free PMC Article

Diagnosis

Shroff S
Med Clin North Am 2023 Mar;107(2):299-315. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.009. PMID: 36759099
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Chen X, Lu Y, Chen T, Li R
Front Cell Infect Microbiol 2021;11:631972. Epub 2021 Apr 7 doi: 10.3389/fcimb.2021.631972. PMID: 33898328Free PMC Article
Ravel J, Moreno I, Simón C
Am J Obstet Gynecol 2021 Mar;224(3):251-257. Epub 2020 Oct 19 doi: 10.1016/j.ajog.2020.10.019. PMID: 33091407
Coudray MS, Madhivanan P
Eur J Obstet Gynecol Reprod Biol 2020 Feb;245:143-148. Epub 2019 Dec 24 doi: 10.1016/j.ejogrb.2019.12.035. PMID: 31901667Free PMC Article

Therapy

Chen R, Li R, Qing W, Zhang Y, Zhou Z, Hou Y, Shi Y, Zhou H, Chen M
Reprod Health 2022 Jun 13;19(1):137. doi: 10.1186/s12978-022-01449-z. PMID: 35698149Free PMC Article
Cohen CR, Wierzbicki MR, French AL, Morris S, Newmann S, Reno H, Green L, Miller S, Powell J, Parks T, Hemmerling A
N Engl J Med 2020 May 14;382(20):1906-1915. doi: 10.1056/NEJMoa1915254. PMID: 32402161Free PMC Article
Lev-Sagie A, Goldman-Wohl D, Cohen Y, Dori-Bachash M, Leshem A, Mor U, Strahilevitz J, Moses AE, Shapiro H, Yagel S, Elinav E
Nat Med 2019 Oct;25(10):1500-1504. Epub 2019 Oct 7 doi: 10.1038/s41591-019-0600-6. PMID: 31591599
van Schalkwyk J, Yudin MH; INFECTIOUS DISEASE COMMITTEE
J Obstet Gynaecol Can 2015 Mar;37(3):266-274. doi: 10.1016/S1701-2163(15)30316-9. PMID: 26001874
Levett PN
West Indian Med J 1989 Sep;38(3):126-32. PMID: 2694618

Prognosis

Kwon MS, Lee HK
Front Immunol 2022;13:919728. Epub 2022 Jun 28 doi: 10.3389/fimmu.2022.919728. PMID: 35837395Free PMC Article
Hillier SL, Bernstein KT, Aral S
J Infect Dis 2021 Aug 16;224(12 Suppl 2):S23-S28. doi: 10.1093/infdis/jiab116. PMID: 34396398Free PMC Article
Cohen CR, Wierzbicki MR, French AL, Morris S, Newmann S, Reno H, Green L, Miller S, Powell J, Parks T, Hemmerling A
N Engl J Med 2020 May 14;382(20):1906-1915. doi: 10.1056/NEJMoa1915254. PMID: 32402161Free PMC Article
Coudray MS, Madhivanan P
Eur J Obstet Gynecol Reprod Biol 2020 Feb;245:143-148. Epub 2019 Dec 24 doi: 10.1016/j.ejogrb.2019.12.035. PMID: 31901667Free PMC Article
Unemo M, Bradshaw CS, Hocking JS, de Vries HJC, Francis SC, Mabey D, Marrazzo JM, Sonder GJB, Schwebke JR, Hoornenborg E, Peeling RW, Philip SS, Low N, Fairley CK
Lancet Infect Dis 2017 Aug;17(8):e235-e279. Epub 2017 Jul 9 doi: 10.1016/S1473-3099(17)30310-9. PMID: 28701272

Clinical prediction guides

Qi F, Fan S, Fang C, Ge L, Lyu J, Huang Z, Zhao S, Zou Y, Huang L, Liu X, Liang Y, Zhang Y, Zhong Y, Zhang H, Xiao L, Zhang X
Front Immunol 2023;14:1125239. Epub 2023 Jul 27 doi: 10.3389/fimmu.2023.1125239. PMID: 37575226Free PMC Article
Burns BL, Rhoads DD, Misra A
J Clin Microbiol 2023 Sep 21;61(9):e0233621. Epub 2023 Jul 3 doi: 10.1128/jcm.02336-21. PMID: 37395657Free PMC Article
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Benef Microbes 2023 Apr 18;14(2):143-152. Epub 2023 Mar 1 doi: 10.3920/BM2022.0091. PMID: 36856121
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
van Schalkwyk J, Yudin MH; INFECTIOUS DISEASE COMMITTEE
J Obstet Gynaecol Can 2015 Mar;37(3):266-274. doi: 10.1016/S1701-2163(15)30316-9. PMID: 26001874

Recent systematic reviews

Zheng N, Guo R, Wang J, Zhou W, Ling Z
Front Cell Infect Microbiol 2021;11:792787. Epub 2021 Nov 22 doi: 10.3389/fcimb.2021.792787. PMID: 34881196Free PMC Article
Peebles K, Velloza J, Balkus JE, McClelland RS, Barnabas RV
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Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, Cole Z, Tinati T, Godfrey K, Dennison E, Bishop NJ, Baird J, Cooper C
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BMJ Clin Evid 2010 Jan 5;2010 PMID: 21718579Free PMC Article

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