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Vitamin K Deficiency Bleeding

MedGen UID:
439355
•Concept ID:
C2718087
•
Disease or Syndrome

Definition

Hemorrhage caused by vitamin K deficiency. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin K Deficiency Bleeding

Professional guidelines

PubMed

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant.
Fiesack S, Smits A, Rayyan M, Allegaert K, Alliet P, Arts W, Bael A, Cornette L, De Guchtenaere A, De Mulder N, George I, Henrion E, Keiren K, Kreins N, Raes M, Philippet P, Van Overmeire B, Van Winckel M, Vlieghe V, Vandenplas Y, On Behalf Of The Groups
Nutrients 2021 Nov 16;13(11) doi: 10.3390/nu13114109. PMID: 34836364Free PMC Article
Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada.
Ng E, Loewy AD
Can Fam Physician 2018 Oct;64(10):736-739. PMID: 30315016Free PMC Article
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domellöf M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9. doi: 10.1097/MPG.0000000000001232. PMID: 27050049

Recent clinical studies

Etiology

Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domellöf M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9. doi: 10.1097/MPG.0000000000001232. PMID: 27050049
Prenatal determination of fetal blood group status.
Avent ND, Finning KM, Martin PG, Soothill PW
Vox Sang 2000;78 Suppl 2:155-62. PMID: 10938946
Vitamin K.
Shearer MJ
Lancet 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9. PMID: 7823718
Vitamin K in infancy.
Lane PA, Hathaway WE
J Pediatr 1985 Mar;106(3):351-9. doi: 10.1016/s0022-3476(85)80656-9. PMID: 3973772

Diagnosis

Take the Shot: A Review of Vitamin K Deficiency.
Shaw MA, Liu A
Pediatr Ann 2023 Feb;52(2):e42-e45. Epub 2023 Feb 1 doi: 10.3928/19382359-20230102-02. PMID: 36779880
Intracranial hemorrhage due to vitamin K deficiency in an infant with arteriovenous malformation.
Go H, Nagano N, Sumi K, Nishimaki H, Morioka I
Pediatr Int 2022 Jan;64(1):e15238. doi: 10.1111/ped.15238. PMID: 35859253
Vitamin K deficient bleeding and COVID-19: How are they related?
Volpe JJ
J Neonatal Perinatal Med 2021;14(3):313-316. doi: 10.3233/NPM-210732. PMID: 34486992
Neonatal vitamin K prophylaxis. Report of Scientific and Standardization Subcommittee on Perinatal Haemostasis.
von Kries R, Hanawa Y
Thromb Haemost 1993 Mar 1;69(3):293-5. PMID: 8470054
Vitamin K and the older infant.
Lukens JN
Am J Dis Child 1972 Nov;124(5):639-40. doi: 10.1001/archpedi.1972.02110170017001. PMID: 5085476

Therapy

Vitamin K prophylaxis in newborns.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):350. doi: 10.1186/s12887-021-02701-4. PMID: 34496783Free PMC Article
Vitamin K Deficiency Bleeding in Infancy.
Araki S, Shirahata A
Nutrients 2020 Mar 16;12(3) doi: 10.3390/nu12030780. PMID: 32187975Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Vitamin K.
Shearer MJ
Lancet 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9. PMID: 7823718
Vitamin K.
Br Med J 1969 Apr 5;2(5648):40. PMID: 5776219Free PMC Article

Prognosis

Vitamin K and the Newborn Infant.
Hand I, Noble L, Abrams SA
Pediatrics 2022 Mar 1;149(3) doi: 10.1542/peds.2021-056036. PMID: 35190810
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
The vitamin K story.
McNinch A
Midwives (1995) 1997 Mar;110(1310):56-8. PMID: 9136433
Neonatal vitamin K prophylaxis. Report of Scientific and Standardization Subcommittee on Perinatal Haemostasis.
von Kries R, Hanawa Y
Thromb Haemost 1993 Mar 1;69(3):293-5. PMID: 8470054
Acquired coagulation disorders.
Prentice CR
Clin Haematol 1985 Jun;14(2):413-42. PMID: 3899441

Clinical prediction guides

Vitamin K insufficiency and the prophylaxis strategy in term healthy infants: A multicentre study.
Perrone S, De Bernardo G, Lembo C, Dell'Orto V, Giordano M, Beretta V, Petrolini C, Gambini L, Toni AL, Parigi G, Fontanarosa I, Natale MP, D'Amato G, Sordino D, Buonocore G
Eur J Clin Invest 2024 Apr;54(4):e14141. Epub 2023 Dec 9 doi: 10.1111/eci.14141. PMID: 38071415
Late vitamin K deficiency bleeding in infants: five-year prospective study.
Al-Zuhairy SH
J Pediatr (Rio J) 2021 Sep-Oct;97(5):514-519. Epub 2020 Oct 13 doi: 10.1016/j.jped.2020.09.003. PMID: 33064995Free PMC Article
Laboratory assessment of vitamin K status.
Card DJ, Gorska R, Harrington DJ
J Clin Pathol 2020 Feb;73(2):70-75. Epub 2019 Dec 20 doi: 10.1136/jclinpath-2019-205997. PMID: 31862867
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, haemorrhage, and neonatal morbidity.
Hackett GA, Campbell S, Gamsu H, Cohen-Overbeek T, Pearce JM
Br Med J (Clin Res Ed) 1987 Jan 3;294(6563):13-6. doi: 10.1136/bmj.294.6563.13. PMID: 3101778Free PMC Article

Recent systematic reviews

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis.
Zeng L, Choonara I, Zhang L, Li Y, Shi J
Eur J Pediatr 2017 May;176(5):581-589. Epub 2017 Mar 9 doi: 10.1007/s00431-017-2877-0. PMID: 28281092
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Prophylactic vitamin K for vitamin K deficiency bleeding in neonates.
Puckett RM, Offringa M
Cochrane Database Syst Rev 2000;2000(4):CD002776. doi: 10.1002/14651858.CD002776. PMID: 11034761Free PMC Article

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