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Lichen planopilaris

MedGen UID:
44150
•Concept ID:
C0023645
•
Disease or Syndrome
Synonyms: Follicular lichen planus; Lichen planus follicularis
SNOMED CT: Lichen planopilaris (64540004); Lichen planus follicularis (64540004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018879
Orphanet: ORPHA525

Definition

A rare cutaneous variant of lichen planus which affects hair follicles. It may occur on its own or in association with more common forms of lichen planus, usually classical type and/or oral lichen planus. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Lichen planopilaris
Follow this link to review classifications for Lichen planopilaris in Orphanet.

Professional guidelines

PubMed

Treatment of lichen planopilaris with baricitinib: A retrospective study.
Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
The Diagnosis and Treatment of Hair and Scalp Diseases.
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article

Recent clinical studies

Etiology

Treatment of lichen planopilaris with baricitinib: A retrospective study.
Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Primary cicatricial alopecia: Lymphocytic primary cicatricial alopecias, including chronic cutaneous lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, and Graham-Little syndrome.
Bolduc C, Sperling LC, Shapiro J
J Am Acad Dermatol 2016 Dec;75(6):1081-1099. doi: 10.1016/j.jaad.2014.09.058. PMID: 27846944
Primary scarring alopecias.
Rigopoulos D, Stamatios G, Ioannides D
Curr Probl Dermatol 2015;47:76-86. Epub 2015 Feb 20 doi: 10.1159/000369407. PMID: 26370646
Red face revisited: Disorders of hair growth and the pilosebaceous unit.
Ramos-e-Silva M, Pirmez R
Clin Dermatol 2014 Nov-Dec;32(6):784-99. Epub 2014 Mar 1 doi: 10.1016/j.clindermatol.2014.02.018. PMID: 25441472

Diagnosis

Lichen planopilaris and frontal fibrosing alopecia: review and update of diagnostic and therapeutic features.
Fechine COC, Valente NYS, Romiti R
An Bras Dermatol 2022 May-Jun;97(3):348-357. Epub 2022 Apr 2 doi: 10.1016/j.abd.2021.08.008. PMID: 35379508Free PMC Article
Lichen Planopilaris.
Xie F, Lehman JS
Mayo Clin Proc 2022 Feb;97(2):208-209. doi: 10.1016/j.mayocp.2021.11.030. PMID: 35120689
Fibrosing alopecia in a pattern distribution.
Griggs J, Trüeb RM, Gavazzoni Dias MFR, Hordinsky M, Tosti A
J Am Acad Dermatol 2021 Dec;85(6):1557-1564. Epub 2020 Jan 8 doi: 10.1016/j.jaad.2019.12.056. PMID: 31926219
Trichoscopy Tips.
Pirmez R, Tosti A
Dermatol Clin 2018 Oct;36(4):413-420. Epub 2018 Aug 14 doi: 10.1016/j.det.2018.05.008. PMID: 30201150
Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination.
Mubki T, Rudnicka L, Olszewska M, Shapiro J
J Am Acad Dermatol 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070. PMID: 25128118

Therapy

JAK inhibitors in lichen planus: a review of pathogenesis and treatments.
Motamed-Sanaye A, Khazaee YF, Shokrgozar M, Alishahi M, Ahramiyanpour N, Amani M
J Dermatolog Treat 2022 Dec;33(8):3098-3103. Epub 2022 Aug 29 doi: 10.1080/09546634.2022.2116926. PMID: 35997540
Treatment of lichen planopilaris with baricitinib: A retrospective study.
Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
Graham-Little syndrome.
Zegarska B, Kallas D, Schwartz RA, Czajkowski R, Uchanska G, Placek W
Acta Dermatovenerol Alp Pannonica Adriat 2010 Oct;19(3):39-42. PMID: 20976421

Prognosis

Frontal Fibrosing Alopecia - a review and a practical guide for clinicians.
Kępińska K, Jałowska M, Bowszyc-Dmochowska M
Ann Agric Environ Med 2022 Jun 24;29(2):169-184. Epub 2021 Aug 31 doi: 10.26444/aaem/141324. PMID: 35767748
Common causes of hair loss - clinical manifestations, trichoscopy and therapy.
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
Red face revisited: Disorders of hair growth and the pilosebaceous unit.
Ramos-e-Silva M, Pirmez R
Clin Dermatol 2014 Nov-Dec;32(6):784-99. Epub 2014 Mar 1 doi: 10.1016/j.clindermatol.2014.02.018. PMID: 25441472
Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination.
Mubki T, Rudnicka L, Olszewska M, Shapiro J
J Am Acad Dermatol 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070. PMID: 25128118
Post-menopausal frontal fibrosing alopecia.
Dawn G, Holmes SC, Moffat D, Munro CS
Clin Exp Dermatol 2003 Jan;28(1):43-5. doi: 10.1046/j.1365-2230.2003.01140.x. PMID: 12558629

Clinical prediction guides

Clinical Characterization and Treatment Response of Folliculitis Decalvans Lichen Planopilaris Phenotypic Spectrum: A Unicentre Retrospective Series of 31 Patients.
Melián-Olivera A, Moreno-Arrones Ó, Burgos-Blasco P, Hermosa-Gelbard Á, Jaén-Olasolo P, Vañó-Galván S, Saceda-Corralo D
Acta Derm Venereol 2024 Feb 19;104:adv12373. doi: 10.2340/actadv.v104.12373. PMID: 38372472Free PMC Article
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Sunscreen and frontal fibrosing alopecia: A review.
Robinson G, McMichael A, Wang SQ, Lim HW
J Am Acad Dermatol 2020 Mar;82(3):723-728. Epub 2019 Oct 22 doi: 10.1016/j.jaad.2019.09.085. PMID: 31654665
A systematic approach to Afro-textured hair disorders: dermatoscopy and when to biopsy.
Yin NC, Tosti A
Dermatol Clin 2014 Apr;32(2):145-51. Epub 2014 Jan 11 doi: 10.1016/j.det.2013.11.005. PMID: 24680001

Recent systematic reviews

A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris.
Husein-ElAhmed H, Husein-ElAhmed S
Dermatology 2024;240(1):103-110. Epub 2023 Oct 18 doi: 10.1159/000534364. PMID: 37852211
Frontal fibrosing alopecia and personal care product use: a systematic review and meta-analysis.
Kam O, Na S, Guo W, Tejeda CI, Kaufmann T
Arch Dermatol Res 2023 Oct;315(8):2313-2331. Epub 2023 Apr 4 doi: 10.1007/s00403-023-02604-7. PMID: 37014396
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Mycophenolate mofetil and lichen planopilaris: systematic review and meta-analysis.
Mostafa N, Phan K, Smith S
J Dermatolog Treat 2022 Feb;33(1):369-372. Epub 2020 Apr 23 doi: 10.1080/09546634.2020.1755416. PMID: 32281437
Hair Transplantation in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review.
Lee JA, Levy DA, Patel KG, Brennan E, Oyer SL
Laryngoscope 2021 Jan;131(1):59-66. Epub 2020 Feb 11 doi: 10.1002/lary.28551. PMID: 32045028

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