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Paraneoplastic Endocrine Syndromes

MedGen UID:
45038
•Concept ID:
C0027670
•
Disease or Syndrome
Synonyms: Ectopic Hormone Syndrome; Ectopic Hormone Syndromes; Endocrine Syndrome, Paraneoplastic; Paraneoplastic Endocrine Syndrome; Syndrome, Ectopic Hormone; Syndrome, Paraneoplastic Endocrine; Syndromes, Ectopic Hormone; Syndromes, Paraneoplastic Endocrine

Definition

Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic Endocrine Syndromes

Professional guidelines

PubMed

Updated Review and Treatment Recommendations on Paraneoplastic Neurologic Syndromes and Chronic Pain.
Blyakhman I, Chakravarthy K
Pain Physician 2019 Sep;22(5):433-445. PMID: 31561645
Paraneoplastic syndromes: an approach to diagnosis and treatment.
Pelosof LC, Gerber DE
Mayo Clin Proc 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099. PMID: 20810794Free PMC Article

Recent clinical studies

Etiology

Pancreatic endocrine tumors.
Oberg K
Semin Oncol 2010 Dec;37(6):594-618. doi: 10.1053/j.seminoncol.2010.10.014. PMID: 21167379
Imaging in the investigation of paraneoplastic syndromes.
Rutherford GC, Dineen RA, O'Connor A
Clin Radiol 2007 Nov;62(11):1021-35. Epub 2007 Sep 12 doi: 10.1016/j.crad.2007.06.005. PMID: 17920860
Ectopic ACTH syndrome: clinicopathological correlations.
Singer W, Kovacs K, Ryan N, Horvath E
J Clin Pathol 1978 Jun;31(6):591-8. doi: 10.1136/jcp.31.6.591. PMID: 209063Free PMC Article
Recent observations related to the chemotherapy and immunology of gestational choriocarcinoma.
Bagshawe KD
Adv Cancer Res 1973;18:231-63. doi: 10.1016/s0065-230x(08)60754-x. PMID: 4592978
The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.
Pearse AG
J Histochem Cytochem 1969 May;17(5):303-13. doi: 10.1177/17.5.303. PMID: 4143745

Diagnosis

Paraneoplastic endocrine syndromes.
Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A
Endocr Relat Cancer 2017 Jun;24(6):R173-R190. Epub 2017 Mar 24 doi: 10.1530/ERC-17-0036. PMID: 28341725
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Extrapituitary acromegaly.
Melmed S
Endocrinol Metab Clin North Am 1991 Sep;20(3):507-18. PMID: 1935918
Paraneoplastic syndromes. I. Endocrine paraneoplasia.
Tagnon HJ
Eur J Cancer Clin Oncol 1981 Sep;17(9):969-85. doi: 10.1016/s0277-5379(81)80002-8. PMID: 7035182
Mediastinal masses.
Silverman NA, Sabiston DC Jr
Surg Clin North Am 1980 Aug;60(4):757-77. doi: 10.1016/s0039-6109(16)42181-x. PMID: 6252642

Therapy

Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Paraneoplastic endocrine syndromes.
Solomon CG, Dluhy RG
Curr Ther Endocrinol Metab 1994;5:537-42. PMID: 7704790
Steroid hormone-producing tumors in man.
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606
Pituitary tumors: diagnosis and therapy.
Cook DM
CA Cancer J Clin 1983 Jul-Aug;33(4):215-36. doi: 10.3322/canjclin.33.4.215. PMID: 6407726
Primary aldosteronism--a review.
Menon M, Mersey JH
Urol Surv 1980 Aug;30(4):95-9. PMID: 7001714

Prognosis

Endocrine paraneoplastic syndromes in lung cancer.
Efthymiou C, Spyratos D, Kontakiotis T
Hormones (Athens) 2018 Sep;17(3):351-358. Epub 2018 Jul 2 doi: 10.1007/s42000-018-0046-0. PMID: 29968234
Paraneoplastic endocrine syndromes.
Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A
Endocr Relat Cancer 2017 Jun;24(6):R173-R190. Epub 2017 Mar 24 doi: 10.1530/ERC-17-0036. PMID: 28341725
Reninoma presenting in pregnancy.
Diker-Cohen T, Abraham SB, Rauschecker M, Papadakis GZ, Munir KM, Brown E, Lyssikatos C, Belyavskaya E, Merino M, Stratakis CA
J Clin Endocrinol Metab 2014 Aug;99(8):2625-6. Epub 2014 May 21 doi: 10.1210/jc.2014-1730. PMID: 24848711Free PMC Article
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Steroid hormone-producing tumors in man.
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Clinical prediction guides

The Impact of Mild Autonomous Cortisol Secretion on Bone Turnover Markers.
Athimulam S, Delivanis D, Thomas M, Young WF, Khosla S, Drake MT, Bancos I
J Clin Endocrinol Metab 2020 May 1;105(5):1469-77. doi: 10.1210/clinem/dgaa120. PMID: 32154561Free PMC Article
Syndromes that Link the Endocrine System and Genitourinary Tract.
Özlük Y, Kılıçaslan I
Turk Patoloji Derg 2015;31 Suppl 1:155-71. doi: 10.5146/tjpath.2015.01322. PMID: 26177325
Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings.
Knosp E, Steiner E, Kitz K, Matula C
Neurosurgery 1993 Oct;33(4):610-7; discussion 617-8. doi: 10.1227/00006123-199310000-00008. PMID: 8232800
Paraneoplastic hypercalcemia in ovarian tumors.
Holtz G, Johnson TR Jr, Schrock ME
Obstet Gynecol 1979 Oct;54(4):483-7. PMID: 492633
Recent observations related to the chemotherapy and immunology of gestational choriocarcinoma.
Bagshawe KD
Adv Cancer Res 1973;18:231-63. doi: 10.1016/s0065-230x(08)60754-x. PMID: 4592978

Recent systematic reviews

Paraneoplastic syndromes associated with gynecological cancers: A systematic review.
Viau M, Renaud MC, Grégoire J, Sebastianelli A, Plante M
Gynecol Oncol 2017 Sep;146(3):661-671. Epub 2017 Jun 24 doi: 10.1016/j.ygyno.2017.06.025. PMID: 28655412
Paraneoplastic humorally mediated hypercalcemia induced by parathyroid hormone-related protein in gynecologic malignancies: a systematic review.
Savvari P, Peitsidis P, Alevizaki M, Dimopoulos MA, Antsaklis A, Papadimitriou CA
Onkologie 2009 Sep;32(8-9):517-23. Epub 2009 Aug 12 doi: 10.1159/000226209. PMID: 19745599

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