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Visceral pain

MedGen UID:
452294
•Concept ID:
C0234245
•
Sign or Symptom
Synonyms: Pain, Visceral; Pains, Visceral; Visceral Pain; Visceral Pains
SNOMED CT: Visceral pain (73645008); Autonomic pain (73645008)

Definition

Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVisceral pain

Professional guidelines

PubMed

Lidocaine Infusions for Pain Management in Pediatrics.
Hall EA, Sauer HE, Davis MS, Anghelescu DL
Paediatr Drugs 2021 Jul;23(4):349-359. Epub 2021 May 26 doi: 10.1007/s40272-021-00454-2. PMID: 34036532Free PMC Article
Abdominal Wall Pain: Clinical Evaluation, Differential Diagnosis, and Treatment.
Shian B, Larson ST
Am Fam Physician 2018 Oct 1;98(7):429-436. PMID: 30252418
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article

Recent clinical studies

Etiology

The TAP block in obese patients: pros and cons.
Ruiz-Tovar J, Albrecht E, Macfarlane A, Coluzzi F
Minerva Anestesiol 2019 Sep;85(9):1024-1031. Epub 2019 Apr 2 doi: 10.23736/S0375-9393.19.13545-6. PMID: 30945517
Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).
Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ
Pain 2019 Jan;160(1):19-27. doi: 10.1097/j.pain.0000000000001384. PMID: 30586067
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2013 Sep;29(5):531-6. doi: 10.1097/MOG.0b013e3283639370. PMID: 23852141Free PMC Article
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article
New concepts of irritable bowel syndrome.
Mertz HR
Curr Gastroenterol Rep 1999 Oct;1(5):433-40. doi: 10.1007/s11894-999-0026-2. PMID: 10980983

Diagnosis

MODERN APPROACH TO DYSPEPSIA.
Medić B, Babić Ž, Banić M, Ljubičić L
Acta Clin Croat 2021 Dec;60(4):731-738. doi: 10.20471/acc.2021.60.04.21. PMID: 35734496Free PMC Article
Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).
Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ
Pain 2019 Jan;160(1):19-27. doi: 10.1097/j.pain.0000000000001384. PMID: 30586067
Abdominal Wall Pain: Clinical Evaluation, Differential Diagnosis, and Treatment.
Shian B, Larson ST
Am Fam Physician 2018 Oct 1;98(7):429-436. PMID: 30252418
Gastrointestinal Physiology and Function.
Greenwood-Van Meerveld B, Johnson AC, Grundy D
Handb Exp Pharmacol 2017;239:1-16. doi: 10.1007/164_2016_118. PMID: 28176047
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article

Therapy

MODERN APPROACH TO DYSPEPSIA.
Medić B, Babić Ž, Banić M, Ljubičić L
Acta Clin Croat 2021 Dec;60(4):731-738. doi: 10.20471/acc.2021.60.04.21. PMID: 35734496Free PMC Article
Lidocaine Infusions for Pain Management in Pediatrics.
Hall EA, Sauer HE, Davis MS, Anghelescu DL
Paediatr Drugs 2021 Jul;23(4):349-359. Epub 2021 May 26 doi: 10.1007/s40272-021-00454-2. PMID: 34036532Free PMC Article
Management Options for Irritable Bowel Syndrome.
Camilleri M
Mayo Clin Proc 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596Free PMC Article
Capsaicin, Nociception and Pain.
Frias B, Merighi A
Molecules 2016 Jun 18;21(6) doi: 10.3390/molecules21060797. PMID: 27322240Free PMC Article
Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.
Moloney RD, Johnson AC, O'Mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF
CNS Neurosci Ther 2016 Feb;22(2):102-17. Epub 2015 Dec 10 doi: 10.1111/cns.12490. PMID: 26662472Free PMC Article

Prognosis

RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives.
Salaga M, Storr M, Martemyanov KA, Fichna J
Bioessays 2016 Apr;38(4):344-54. Epub 2016 Jan 28 doi: 10.1002/bies.201500118. PMID: 26817719Free PMC Article
Preclinical Assessment of Inflammatory Pain.
Muley MM, Krustev E, McDougall JJ
CNS Neurosci Ther 2016 Feb;22(2):88-101. Epub 2015 Dec 10 doi: 10.1111/cns.12486. PMID: 26663896Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2013 Sep;29(5):531-6. doi: 10.1097/MOG.0b013e3283639370. PMID: 23852141Free PMC Article
Medical treatment of acute pancreatitis.
Mayerle J, Simon P, Lerch MM
Gastroenterol Clin North Am 2004 Dec;33(4):855-69, viii. doi: 10.1016/j.gtc.2004.07.012. PMID: 15528022
New concepts of irritable bowel syndrome.
Mertz HR
Curr Gastroenterol Rep 1999 Oct;1(5):433-40. doi: 10.1007/s11894-999-0026-2. PMID: 10980983

Clinical prediction guides

Interactions between the painful disorders and the autonomic nervous system.
Arslan D, Ünal Çevik I
Agri 2022 Jul;34(3):155-165. doi: 10.14744/agri.2021.43078. PMID: 35792695
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity.
Zhu Y, Xu F, Lu D, Rong P, Cheng J, Li M, Gong Y, Sun C, Wei W, Lin L, Chen JDZ
Am J Physiol Gastrointest Liver Physiol 2021 May 1;320(5):G700-G711. Epub 2021 Feb 24 doi: 10.1152/ajpgi.00426.2020. PMID: 33624527Free PMC Article
Preclinical Assessment of Inflammatory Pain.
Muley MM, Krustev E, McDougall JJ
CNS Neurosci Ther 2016 Feb;22(2):88-101. Epub 2015 Dec 10 doi: 10.1111/cns.12486. PMID: 26663896Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2013 Sep;29(5):531-6. doi: 10.1097/MOG.0b013e3283639370. PMID: 23852141Free PMC Article
Medical treatment of acute pancreatitis.
Mayerle J, Simon P, Lerch MM
Gastroenterol Clin North Am 2004 Dec;33(4):855-69, viii. doi: 10.1016/j.gtc.2004.07.012. PMID: 15528022

Recent systematic reviews

P2X3 and P2X2/3 receptors inhibition produces a consistent analgesic efficacy: A systematic review and meta-analysis of preclinical studies.
Huerta MÁ, Marcos-Frutos D, Nava J, García-Ramos A, Tejada MÁ, Roza C
Eur J Pharmacol 2024 Dec 5;984:177052. Epub 2024 Oct 10 doi: 10.1016/j.ejphar.2024.177052. PMID: 39393665
Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review.
Halloum W, Dughem YA, Beier D, Pellesi L
J Headache Pain 2024 Jul 12;25(1):112. doi: 10.1186/s10194-024-01821-3. PMID: 38997662Free PMC Article
Prevalence of chronic pain after spinal cord injury: a systematic review and meta-analysis.
Hunt C, Moman R, Peterson A, Wilson R, Covington S, Mustafa R, Murad MH, Hooten WM
Reg Anesth Pain Med 2021 Apr;46(4):328-336. Epub 2021 Jan 6 doi: 10.1136/rapm-2020-101960. PMID: 33408161
Sympathetic blocks for visceral cancer pain management: A systematic review and EAPC recommendations.
Mercadante S, Klepstad P, Kurita GP, Sjøgren P, Giarratano A; European Palliative Care Research Collaborative (EPCRC)
Crit Rev Oncol Hematol 2015 Dec;96(3):577-83. Epub 2015 Aug 1 doi: 10.1016/j.critrevonc.2015.07.014. PMID: 26297518
Systematic review: instruments to assess abdominal pain in irritable bowel syndrome.
Mujagic Z, Keszthelyi D, Aziz Q, Reinisch W, Quetglas EG, De Leonardis F, Segerdahl M, Masclee AA
Aliment Pharmacol Ther 2015 Nov;42(9):1064-81. Epub 2015 Aug 20 doi: 10.1111/apt.13378. PMID: 26290286

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