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Oroya fever

MedGen UID:
45234
•Concept ID:
C0029307
•
Disease or Syndrome
Synonyms: Carrion Disease; Carrion's Disease; Disease, Carrion; Disease, Carrion's; Fever, Oroya; Oroya Fever
SNOMED CT: Oroya fever (240453002)
 
Monarch Initiative: MONDO:0018984
Orphanet: ORPHA64692

Definition

An infection that is caused by Bartonella bacilliformis, which is transmitted to humans from infected sandflies. The acute phase (Oroya Fever) is characterized by fever, headache, myalgia, enlargement of the lymph nodes, and anemia. The chronic phase (verruga peruana/Peruvian wart) is characterized by benign, eruptive lesions that are bleeding and pruritic, arthralgia, and malaise. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOroya fever

Professional guidelines

PubMed

Diagnosis and treatment of Bartonella endocarditis.
Kuncová K, Žemličková H, Jäger J, Ryšková L, Plíšková L, Bolehovská R, Pojar M
Epidemiol Mikrobiol Imunol 2019 Spring;68(2):104-108. PMID: 31398984
Pathogenicity and treatment of Bartonella infections.
Angelakis E, Raoult D
Int J Antimicrob Agents 2014 Jul;44(1):16-25. Epub 2014 May 9 doi: 10.1016/j.ijantimicag.2014.04.006. PMID: 24933445
Bartonella infection: treatment and drug resistance.
Biswas S, Rolain JM
Future Microbiol 2010 Nov;5(11):1719-31. doi: 10.2217/fmb.10.133. PMID: 21133691

Recent clinical studies

Etiology

Multi-Locus Sequence Typing of Bartonella bacilliformis DNA Performed Directly from Blood of Patients with Oroya's Fever During a Peruvian Outbreak.
Pons MJ, Silva-Caso W, Del Valle-Mendoza J, Ruiz J
PLoS Negl Trop Dis 2016 Jan;10(1):e0004391. Epub 2016 Jan 29 doi: 10.1371/journal.pntd.0004391. PMID: 26824740Free PMC Article
Oroya fever and verruga peruana: bartonelloses unique to South America.
Minnick MF, Anderson BE, Lima A, Battisti JM, Lawyer PG, Birtles RJ
PLoS Negl Trop Dis 2014 Jul;8(7):e2919. Epub 2014 Jul 17 doi: 10.1371/journal.pntd.0002919. PMID: 25032975Free PMC Article
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
An outbreak of bartonellosis in Zamora Chinchipe Province in Ecuador.
Cooper P, Guderian R, Orellana P, Sandoval C, Olalla H, Valdez M, Calvopiña M, Guevara A, Griffin G
Trans R Soc Trop Med Hyg 1997 Sep-Oct;91(5):544-6. doi: 10.1016/s0035-9203(97)90019-5. PMID: 9463663
An epidemic of Oroya fever in the Peruvian Andes.
Gray GC, Johnson AA, Thornton SA, Smith WA, Knobloch J, Kelley PW, Obregon Escudero L, Arones Huayda M, Wignall FS
Am J Trop Med Hyg 1990 Mar;42(3):215-21. doi: 10.4269/ajtmh.1990.42.215. PMID: 2316791

Diagnosis

Bartonella spp. Bloodstream Infection in a Canadian Family.
Breitschwerdt EB, Maggi RG, Quach C, Bradley JM
Vector Borne Zoonotic Dis 2019 Apr;19(4):234-241. Epub 2018 Dec 27 doi: 10.1089/vbz.2018.2353. PMID: 30589638
Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination.
Sanchez Clemente N, Ugarte-Gil CA, Solórzano N, Maguiña C, Pachas P, Blazes D, Bailey R, Mabey D, Moore D
PLoS Negl Trop Dis 2012;6(10):e1819. Epub 2012 Oct 25 doi: 10.1371/journal.pntd.0001819. PMID: 23145188Free PMC Article
Bartonella spp.: throwing light on uncommon human infections.
Kaiser PO, Riess T, O'Rourke F, Linke D, Kempf VA
Int J Med Microbiol 2011 Jan;301(1):7-15. Epub 2010 Sep 15 doi: 10.1016/j.ijmm.2010.06.004. PMID: 20833105
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Bartonella (Rochalimaea) infections: beyond cat scratch.
Schwartzman W
Annu Rev Med 1996;47:355-64. doi: 10.1146/annurev.med.47.1.355. PMID: 8712787

Therapy

A bacteriophage-like particle from Bartonella bacilliformis.
Barbian KD, Minnick MF
Microbiology (Reading) 2000 Mar;146 ( Pt 3):599-609. doi: 10.1099/00221287-146-3-599. PMID: 10746763
An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998.
Ellis BA, Rotz LD, Leake JA, Samalvides F, Bernable J, Ventura G, Padilla C, Villaseca P, Beati L, Regnery R, Childs JE, Olson JG, Carrillo CP
Am J Trop Med Hyg 1999 Aug;61(2):344-9. doi: 10.4269/ajtmh.1999.61.344. PMID: 10463692
An epidemic of Oroya fever in the Peruvian Andes.
Gray GC, Johnson AA, Thornton SA, Smith WA, Knobloch J, Kelley PW, Obregon Escudero L, Arones Huayda M, Wignall FS
Am J Trop Med Hyg 1990 Mar;42(3):215-21. doi: 10.4269/ajtmh.1990.42.215. PMID: 2316791

Prognosis

An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998.
Ellis BA, Rotz LD, Leake JA, Samalvides F, Bernable J, Ventura G, Padilla C, Villaseca P, Beati L, Regnery R, Childs JE, Olson JG, Carrillo CP
Am J Trop Med Hyg 1999 Aug;61(2):344-9. doi: 10.4269/ajtmh.1999.61.344. PMID: 10463692
Characterization of a two-gene locus from Bartonella bacilliformis associated with the ability to invade human erythrocytes.
Mitchell SJ, Minnick MF
Infect Immun 1995 Apr;63(4):1552-62. doi: 10.1128/iai.63.4.1552-1562.1995. PMID: 7890422Free PMC Article

Clinical prediction guides

Revisiting Bartonella bacilliformis MLST.
Ruiz J, Pons MJ
Infect Genet Evol 2018 Sep;63:231-235. Epub 2018 Jun 2 doi: 10.1016/j.meegid.2018.05.032. PMID: 29864510
Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination.
Sanchez Clemente N, Ugarte-Gil CA, Solórzano N, Maguiña C, Pachas P, Blazes D, Bailey R, Mabey D, Moore D
PLoS Negl Trop Dis 2012;6(10):e1819. Epub 2012 Oct 25 doi: 10.1371/journal.pntd.0001819. PMID: 23145188Free PMC Article
Skin diseases associated with Bartonella infection: facts and controversies.
Piérard-Franchimont C, Quatresooz P, Piérard GE
Clin Dermatol 2010 Sep-Oct;28(5):483-8. doi: 10.1016/j.clindermatol.2010.03.003. PMID: 20797506
The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes.
Vayssier-Taussat M, Le Rhun D, Deng HK, Biville F, Cescau S, Danchin A, Marignac G, Lenaour E, Boulouis HJ, Mavris M, Arnaud L, Yang H, Wang J, Quebatte M, Engel P, Saenz H, Dehio C
PLoS Pathog 2010 Jun 10;6(6):e1000946. doi: 10.1371/journal.ppat.1000946. PMID: 20548954Free PMC Article
An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998.
Ellis BA, Rotz LD, Leake JA, Samalvides F, Bernable J, Ventura G, Padilla C, Villaseca P, Beati L, Regnery R, Childs JE, Olson JG, Carrillo CP
Am J Trop Med Hyg 1999 Aug;61(2):344-9. doi: 10.4269/ajtmh.1999.61.344. PMID: 10463692

Recent systematic reviews

Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination.
Sanchez Clemente N, Ugarte-Gil CA, Solórzano N, Maguiña C, Pachas P, Blazes D, Bailey R, Mabey D, Moore D
PLoS Negl Trop Dis 2012;6(10):e1819. Epub 2012 Oct 25 doi: 10.1371/journal.pntd.0001819. PMID: 23145188Free PMC Article

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