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Pancreatic Moderately Differentiated Ductal Adenocarcinoma

MedGen UID:
459366
•Concept ID:
C2987140
•
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Moderately Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment.
Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA
Ann Surg 2024 Aug 1;280(2):317-324. Epub 2023 Oct 23 doi: 10.1097/SLA.0000000000006142. PMID: 37870253Free PMC Article
Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response.
Braun R, Lapshyna O, Watzelt J, Drenckhan M, Künstner A, Färber B, Hael AAM, Bolm L, Honselmann KC, Konukiewitz B, Castven D, Spielmann M, Gorantla SP, Busch H, Marquardt JU, Keck T, Wellner UF, Ungefroren H
Cells 2023 Feb 11;12(4) doi: 10.3390/cells12040587. PMID: 36831254Free PMC Article
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article

Recent clinical studies

Etiology

Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment.
Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA
Ann Surg 2024 Aug 1;280(2):317-324. Epub 2023 Oct 23 doi: 10.1097/SLA.0000000000006142. PMID: 37870253Free PMC Article
Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
A Pilot Study Evaluating Serum MMP7 as a Preoperative Prognostic Marker for Pancreatic Ductal Adenocarcinoma Patients.
Wang SC, Parekh JR, Porembka MR, Nathan H, D'Angelica MI, DeMatteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ
J Gastrointest Surg 2016 May;20(5):899-904. Epub 2016 Feb 26 doi: 10.1007/s11605-015-3057-z. PMID: 26921028Free PMC Article

Diagnosis

Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment.
Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA
Ann Surg 2024 Aug 1;280(2):317-324. Epub 2023 Oct 23 doi: 10.1097/SLA.0000000000006142. PMID: 37870253Free PMC Article
Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Therapy

Correlation of dynamic contrast-enhanced ultrasonography and the Ki-67 labelling index in pancreatic ductal adenocarcinoma.
Lin XJ, Zhu S, Wang D, Chen JY, Wei SX, Chen SY, Luo HC
World J Gastroenterol 2024 Nov 28;30(44):4697-4708. Epub 2024 Dec 28 doi: 10.3748/wjg.v30.i44.4697. PMID: 39610780Free PMC Article
Influence of pancreatic fistula on survival after upfront pancreatoduodenectomy for pancreatic ductal adenocarcinoma: multicentre retrospective study.
Castanet F, Dembinski J, Cabarrou B, Garnier J, Laurent C, Regenet N, Sa Cunha A, Maulat C, Chiche L, Pittau G, Carrère N, Regimbeau JM, Turrini O, Sauvanet A, Muscari F
BJS Open 2024 Sep 3;8(5) doi: 10.1093/bjsopen/zrae125. PMID: 39453763Free PMC Article
Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Prognosis

Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands J, Dong X
J Hematol Oncol 2019 Dec 30;12(1):144. doi: 10.1186/s13045-019-0837-z. PMID: 31888763Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
A Pilot Study Evaluating Serum MMP7 as a Preoperative Prognostic Marker for Pancreatic Ductal Adenocarcinoma Patients.
Wang SC, Parekh JR, Porembka MR, Nathan H, D'Angelica MI, DeMatteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ
J Gastrointest Surg 2016 May;20(5):899-904. Epub 2016 Feb 26 doi: 10.1007/s11605-015-3057-z. PMID: 26921028Free PMC Article

Clinical prediction guides

Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment.
Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA
Ann Surg 2024 Aug 1;280(2):317-324. Epub 2023 Oct 23 doi: 10.1097/SLA.0000000000006142. PMID: 37870253Free PMC Article
Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma.
Chen X, Mo S, Zhang Y, Ma H, Lu Z, Yu S, Chen J
J Pathol Clin Res 2022 May;8(3):268-278. Epub 2022 Jan 27 doi: 10.1002/cjp2.260. PMID: 35083884Free PMC Article
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands J, Dong X
J Hematol Oncol 2019 Dec 30;12(1):144. doi: 10.1186/s13045-019-0837-z. PMID: 31888763Free PMC Article
A Pilot Study Evaluating Serum MMP7 as a Preoperative Prognostic Marker for Pancreatic Ductal Adenocarcinoma Patients.
Wang SC, Parekh JR, Porembka MR, Nathan H, D'Angelica MI, DeMatteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ
J Gastrointest Surg 2016 May;20(5):899-904. Epub 2016 Feb 26 doi: 10.1007/s11605-015-3057-z. PMID: 26921028Free PMC Article

Recent systematic reviews

Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Systematic review and meta-analysis: Diagnostic performance of DNA alterations in pancreatic juice for the detection of pancreatic cancer.
Visser IJ, Levink IJM, Peppelenbosch MP, Fuhler GM, Bruno MJ, Cahen DL
Pancreatology 2022 Nov;22(7):973-986. Epub 2022 Jul 7 doi: 10.1016/j.pan.2022.06.260. PMID: 35864067

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