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Pancreatic Serous Adenoma

MedGen UID:
459395
•Concept ID:
C2987169
•
Neoplastic Process

Definition

A benign, non-metastasizing, usually cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss. [from NCI]

Professional guidelines

PubMed

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Solid serous cystadenoma of the pancreas: A rare tumor with challenging differential diagnosis.
Saragoni L, Pacilio CA, Cavaliere D, Limarzi F, Isopi C, Ercolani G
Hepatobiliary Pancreat Dis Int 2022 Jun;21(3):303-306. Epub 2021 Jun 26 doi: 10.1016/j.hbpd.2021.06.005. PMID: 34256995
Cystic pancreatic lesions: can we diagnose them accurately what to look for? FNA marker molecular analysis resection, surveillance, or endoscopic treatment?
Brugge WR
Endoscopy 2006 Jun;38 Suppl 1:S40-7. doi: 10.1055/s-2006-946650. PMID: 16802222

Recent clinical studies

Etiology

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Rare pancreatic masses: a pictorial review of radiological concepts.
Bezerra ROF, Machado MC, Dos Santos Mota MM, Ezzedine TA, Siqueira LTB, Cerri GG
Clin Imaging 2018 Jul-Aug;50:314-323. Epub 2018 May 4 doi: 10.1016/j.clinimag.2018.05.004. PMID: 29751204
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Cystic Neoplasms of the Pancreas.
Chandwani R, Allen PJ
Annu Rev Med 2016;67:45-57. Epub 2015 Nov 6 doi: 10.1146/annurev-med-051914-022011. PMID: 26565675
Histology of cystic tumors of the pancreas.
Compton CC
Gastrointest Endosc Clin N Am 2002 Oct;12(4):673-96. doi: 10.1016/s1052-5157(02)00023-5. PMID: 12607779

Diagnosis

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Calcified pancreatic and peripancreatic neoplasms: spectrum of pathologies.
Verde F, Fishman EK
Abdom Radiol (NY) 2017 Nov;42(11):2686-2697. doi: 10.1007/s00261-017-1182-8. PMID: 28785786
Cystic Neoplasms of the Pancreas.
Chandwani R, Allen PJ
Annu Rev Med 2016;67:45-57. Epub 2015 Nov 6 doi: 10.1146/annurev-med-051914-022011. PMID: 26565675
Benign pancreatic tumors.
Reddy S, Wolfgang CL
Surg Clin North Am 2007 Dec;87(6):1359-78, viii. doi: 10.1016/j.suc.2007.08.009. PMID: 18053836
Surgery of cystic neoplasms.
Fernández-del Castillo C
Gastrointest Endosc Clin N Am 2002 Oct;12(4):803-12, ix. doi: 10.1016/s1052-5157(02)00027-2. PMID: 12613444

Therapy

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Pancreatic serous cystadenoma with a positive octreotide scan.
Canakis A, Kesar V, Hardy N, Legesse TB, Darwin P
Gastrointest Endosc 2022 Jun;95(6):1269-1270. Epub 2022 Feb 2 doi: 10.1016/j.gie.2022.01.022. PMID: 35122809
New treatment of the pancreatic cystic neoplasm: Endoscopic ultrasonography-guided radiofrequency ablation combined with lauromacrogol ablation.
Feng X, Linghu E, Chai N, Li H
Turk J Gastroenterol 2018 Jan;29(1):101-104. Epub 2017 Oct 30 doi: 10.5152/tjg.2017.17340. PMID: 29082889Free PMC Article
Spleen-preserving distal pancreatectomy.
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554
Central pancreatectomy revisited.
Roggin KK, Rudloff U, Blumgart LH, Brennan MF
J Gastrointest Surg 2006 Jun;10(6):804-12. doi: 10.1016/j.gassur.2005.11.012. PMID: 16769536

Prognosis

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Approach to pancreatic cystic lesions.
Moparty B, Brugge WR
Curr Gastroenterol Rep 2007 Apr;9(2):130-5. doi: 10.1007/s11894-007-0007-2. PMID: 17418058
Nonmucinous cystic pancreatic neoplasms.
Anderson MA, Scheiman JM
Gastrointest Endosc Clin N Am 2002 Oct;12(4):769-79, viii. doi: 10.1016/s1052-5157(02)00028-4. PMID: 12607786
Histology of cystic tumors of the pancreas.
Compton CC
Gastrointest Endosc Clin N Am 2002 Oct;12(4):673-96. doi: 10.1016/s1052-5157(02)00023-5. PMID: 12607779

Clinical prediction guides

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Non-inflammatory pancreatic cysts: from diagnosis to treatment (97 cases series).
Amico EC, Salgado CTS, Alves JR, Liguori AAL, Sousa RL
Rev Col Bras Cir 2021;48:e20213009. Epub 2021 Nov 22 doi: 10.1590/0100-6991e-20213009. PMID: 34816881Free PMC Article
Therapeutic Approach to Cystic Neoplasms of the Pancreas.
Al Efishat M, Allen PJ
Surg Oncol Clin N Am 2016 Apr;25(2):351-61. doi: 10.1016/j.soc.2015.11.006. PMID: 27013369Free PMC Article
Clinical decision making in the management of pancreatic cystic neoplasms.
Atiq M, Suzuki R, Khan AS, Krishna SG, Ridgway TM, Guha S, Hernandez LV, Nealon WH, Lee JH, Bhutani MS
Expert Rev Gastroenterol Hepatol 2013 May;7(4):353-60. doi: 10.1586/egh.13.23. PMID: 23639093
Approach to pancreatic cystic lesions.
Moparty B, Brugge WR
Curr Gastroenterol Rep 2007 Apr;9(2):130-5. doi: 10.1007/s11894-007-0007-2. PMID: 17418058

Recent systematic reviews

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Pancreatic lesions in von Hippel-Lindau disease? A systematic review and meta-synthesis of the literature.
Charlesworth M, Verbeke CS, Falk GA, Walsh M, Smith AM, Morris-Stiff G
J Gastrointest Surg 2012 Jul;16(7):1422-8. Epub 2012 Feb 28 doi: 10.1007/s11605-012-1847-0. PMID: 22370733

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