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Osteonecrosis of jaw caused by bisphosphonate

MedGen UID:
465245
Concept ID:
C3178777
Pathologic Function
Synonyms: Bisphosphonate Associated Osteonecrosis of the Jaw; Bisphosphonate Associated Osteonecrosis of the Jaws; Bisphosphonate Induced Osteonecrosis of the Jaw; Bisphosphonate Induced Osteonecrosis of the Jaws; Bisphosphonate Related Osteonecrosis of the Jaw; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bisphosphonate-Associated Osteonecrosis of the Jaws; Bisphosphonate-Induced Osteonecrosis of the Jaw; Bisphosphonate-Induced Osteonecrosis of the Jaws; Bisphosphonate-Related Osteonecrosis of the Jaw; Osteonecrosis of the Jaw, Bisphosphonate Associated; Osteonecrosis of the Jaw, Bisphosphonate Induced; Osteonecrosis of the Jaw, Bisphosphonate Related; Osteonecrosis of the Jaw, Bisphosphonate-Associated; Osteonecrosis of the Jaw, Bisphosphonate-Induced; Osteonecrosis of the Jaw, Bisphosphonate-Related; Osteonecrosis of the Jaws, Bisphosphonate Associated; Osteonecrosis of the Jaws, Bisphosphonate Induced; Osteonecrosis of the Jaws, Bisphosphonate Related; Osteonecrosis of the Jaws, Bisphosphonate-Associated; Osteonecrosis of the Jaws, Bisphosphonate-Induced; Osteonecrosis of the Jaws, Bisphosphonate-Related
SNOMED CT: Bisphosphonate related osteonecrosis of jaw (699687003); Osteonecrosis of jaw caused by bisphosphonate (699687003); Osteonecrosis of jaw caused by diphosphonate (699687003); Avascular necrosis of bone of jaw caused by bisphosphonate (699687003); Aseptic necrosis of bone of jaw caused by bisphosphonate (699687003)

Definition

Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteonecrosis of jaw caused by bisphosphonate

Professional guidelines

PubMed

Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F; American Association of Oral and Maxillofacial Surgeons
J Oral Maxillofac Surg 2014 Oct;72(10):1938-56. Epub 2014 May 5 doi: 10.1016/j.joms.2014.04.031. PMID: 25234529

Recent clinical studies

Etiology

Bedogni A, Mauceri R, Fusco V, Bertoldo F, Bettini G, Di Fede O, Lo Casto A, Marchetti C, Panzarella V, Saia G, Vescovi P, Campisi G
Oral Dis 2024 Sep;30(6):3679-3709. Epub 2024 Feb 5 doi: 10.1111/odi.14887. PMID: 38317291
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ
J Clin Endocrinol Metab 2022 Apr 19;107(5):1441-1460. doi: 10.1210/clinem/dgab888. PMID: 34922381Free PMC Article
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

Diagnosis

Bedogni A, Mauceri R, Fusco V, Bertoldo F, Bettini G, Di Fede O, Lo Casto A, Marchetti C, Panzarella V, Saia G, Vescovi P, Campisi G
Oral Dis 2024 Sep;30(6):3679-3709. Epub 2024 Feb 5 doi: 10.1111/odi.14887. PMID: 38317291
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F; American Association of Oral and Maxillofacial Surgeons
J Oral Maxillofac Surg 2014 Oct;72(10):1938-56. Epub 2014 May 5 doi: 10.1016/j.joms.2014.04.031. PMID: 25234529

Therapy

Billington E, Aghajafari F, Skulsky E, Kline GA
BMJ 2024 Aug 21;386:e076898. doi: 10.1136/bmj-2023-076898. PMID: 39168493
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ
J Clin Endocrinol Metab 2022 Apr 19;107(5):1441-1460. doi: 10.1210/clinem/dgab888. PMID: 34922381Free PMC Article
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

Prognosis

Aguirre JI, Castillo EJ, Kimmel DB
Bone 2021 Dec;153:116184. Epub 2021 Sep 11 doi: 10.1016/j.bone.2021.116184. PMID: 34520898Free PMC Article
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Dunphy L, Salzano G, Gerber B, Graystone J
BMJ Case Rep 2020 Jan 5;13(1) doi: 10.1136/bcr-2018-224455. PMID: 31907213Free PMC Article
Morrison A, Khan A, Tetradis S, Peters E
J Can Dent Assoc 2015;81:f19. PMID: 26679333
Assaf AT, Jürgens TP, Benecke AW, Riecke B, Blessmann M, Zrnc TA, Much CC, Heiland M, Friedrich RE
J Oral Facial Pain Headache 2014 Winter;28(1):80-90. doi: 10.11607/jop.994. PMID: 24482791

Clinical prediction guides

Everts-Graber J, Lehmann D, Burkard JP, Schaller B, Gahl B, Häuselmann H, Studer U, Ziswiler HR, Reichenbach S, Lehmann T
J Bone Miner Res 2022 Feb;37(2):340-348. Epub 2021 Nov 30 doi: 10.1002/jbmr.4472. PMID: 34787342
Aguirre JI, Castillo EJ, Kimmel DB
Bone 2021 Dec;153:116184. Epub 2021 Sep 11 doi: 10.1016/j.bone.2021.116184. PMID: 34520898Free PMC Article
Dunphy L, Salzano G, Gerber B, Graystone J
BMJ Case Rep 2020 Jan 5;13(1) doi: 10.1136/bcr-2018-224455. PMID: 31907213Free PMC Article
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O
Cochrane Database Syst Rev 2017 Oct 6;10(10):CD012432. doi: 10.1002/14651858.CD012432.pub2. PMID: 28983908Free PMC Article
Morrison A, Khan A, Tetradis S, Peters E
J Can Dent Assoc 2015;81:f19. PMID: 26679333

Recent systematic reviews

Goker F, Grecchi E, Grecchi F, Francetti L, Del Fabbro M
Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2662-2673. doi: 10.26355/eurrev_202103_25430. PMID: 33829453
Ferreira Jr LH Jr, Mendonça Jr KD Jr, Chaves de Souza J, Soares Dos Reis DC, do Carmo Faleiros Veloso Guedes C, de Souza Castro Filice L, Bruzadelli Macedo S, Soares Rocha F
Minerva Dent Oral Sci 2021 Feb;70(1):49-57. Epub 2020 Sep 22 doi: 10.23736/S2724-6329.20.04306-X. PMID: 32960522
Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL, Migliorati CA, Khan A, Morrison A, Anderson H, Murphy BA, Alston-Johnson D, Mendes RA, Beadle BM, Jensen SB, Saunders DP
J Clin Oncol 2019 Sep 1;37(25):2270-2290. Epub 2019 Jul 22 doi: 10.1200/JCO.19.01186. PMID: 31329513
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O
Cochrane Database Syst Rev 2017 Oct 6;10(10):CD012432. doi: 10.1002/14651858.CD012432.pub2. PMID: 28983908Free PMC Article
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

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