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Zinc deficiency

MedGen UID:
472966
•Concept ID:
C0235950
•
Disease or Syndrome
Synonym: Zinc Deficiency Disorder
SNOMED CT: Zinc deficiency (238124008)

Definition

A genetic or acquired metabolic disorder that is associated with zinc deficiency in the tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZinc deficiency

Professional guidelines

PubMed

Zinc deficiency: its characterization and treatment.
Prasad AS
Met Ions Biol Syst 2004;41:103-37. PMID: 15206115
The treatment of zinc deficiency is an immunotherapy.
Hadden JW
Int J Immunopharmacol 1995 Sep;17(9):697-701. doi: 10.1016/0192-0561(95)00062-7. PMID: 8582781
Human zinc deficiency, endocrine manifestations and response to treatment.
Sandstead HH, Prasad AS, Schulert AR, Farid Z, Miale A Jr, Bassilly S, Darby WJ
Am J Clin Nutr 1967 May;20(5):422-42. doi: 10.1093/ajcn/20.5.422. PMID: 6023853

Recent clinical studies

Etiology

Role of zinc in health and disease.
Stiles LI, Ferrao K, Mehta KJ
Clin Exp Med 2024 Feb 17;24(1):38. doi: 10.1007/s10238-024-01302-6. PMID: 38367035Free PMC Article
Dietary and Physiological Effects of Zinc on the Immune System.
Wessels I, Fischer HJ, Rink L
Annu Rev Nutr 2021 Oct 11;41:133-175. Epub 2021 Jul 13 doi: 10.1146/annurev-nutr-122019-120635. PMID: 34255547
Role of zinc in female reproduction.
Garner TB, Hester JM, Carothers A, Diaz FJ
Biol Reprod 2021 May 7;104(5):976-994. doi: 10.1093/biolre/ioab023. PMID: 33598687Free PMC Article
The Role of Zinc in Antiviral Immunity.
Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G
Adv Nutr 2019 Jul 1;10(4):696-710. doi: 10.1093/advances/nmz013. PMID: 31305906Free PMC Article
Zinc: an essential micronutrient.
Saper RB, Rash R
Am Fam Physician 2009 May 1;79(9):768-72. PMID: 20141096Free PMC Article

Diagnosis

Acrodermatitis Enteropathica.
Sivakumar A, Vageshappa RK, Kumari R
JAMA Dermatol 2024 Jan 1;160(1):102. doi: 10.1001/jamadermatol.2023.4147. PMID: 37938848
Acrodermatitis Enteropathica.
Zhao M, Shen C
N Engl J Med 2023 Nov 9;389(19):1803. Epub 2023 Nov 4 doi: 10.1056/NEJMicm2304003. PMID: 37929839
Zinc Deficiency-Associated Dermatitis.
Schröder SD, Griebl SW
N Engl J Med 2020 Oct 29;383(18):e103. doi: 10.1056/NEJMicm2003516. PMID: 33113298
Acrodermatitis Enteropathica.
Kumar S, Thakur V, Choudhary R, Vinay K
J Pediatr 2020 May;220:258-259. Epub 2020 Feb 21 doi: 10.1016/j.jpeds.2020.01.017. PMID: 32093930
Nutrition and hair: deficiencies and supplements.
Finner AM
Dermatol Clin 2013 Jan;31(1):167-72. Epub 2012 Oct 18 doi: 10.1016/j.det.2012.08.015. PMID: 23159185

Therapy

Role of zinc in health and disease.
Stiles LI, Ferrao K, Mehta KJ
Clin Exp Med 2024 Feb 17;24(1):38. doi: 10.1007/s10238-024-01302-6. PMID: 38367035Free PMC Article
Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications.
Wang J, Um P, Dickerman BA, Liu J
Nutrients 2018 May 9;10(5) doi: 10.3390/nu10050584. PMID: 29747386Free PMC Article
Zinc: an essential micronutrient.
Saper RB, Rash R
Am Fam Physician 2009 May 1;79(9):768-72. PMID: 20141096Free PMC Article
Zinc requirements and the risks and benefits of zinc supplementation.
Maret W, Sandstead HH
J Trace Elem Med Biol 2006;20(1):3-18. Epub 2006 Feb 21 doi: 10.1016/j.jtemb.2006.01.006. PMID: 16632171
Acrodermatitis enteropathica.
Danbolt N
Br J Dermatol 1979 Jan;100(1):37-40. doi: 10.1111/j.1365-2133.1979.tb03567.x. PMID: 427011

Prognosis

Zinc supplementation decreased incidence of grade ≥2 hand-foot skin reaction induced by regorafenib: A phase II randomized clinical trial.
Huang WK, Hsu HC, Yang TS, Lu CW, Pan YR, Wu CE, Chung WH, Hung SI, Yeh CN
Eur J Cancer 2023 Dec;195:113286. Epub 2023 Nov 13 doi: 10.1016/j.ejca.2023.113286. PMID: 37968194
Incidence and Predictors of Zinc Deficiency in Stable Peritoneal Dialysis Patients.
Panorchan K, Davenport A
Perit Dial Int 2015 Sep-Oct;35(5):597-9. doi: 10.3747/pdi.2014.00134. PMID: 26450484Free PMC Article
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas).
Lakdawala N, Grant-Kels JM
Clin Dermatol 2015 Jul-Aug;33(4):414-9. Epub 2015 Apr 8 doi: 10.1016/j.clindermatol.2015.04.002. PMID: 26051055
Global burden of childhood pneumonia and diarrhoea.
Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O'Brien KL, Campbell H, Black RE
Lancet 2013 Apr 20;381(9875):1405-1416. Epub 2013 Apr 12 doi: 10.1016/S0140-6736(13)60222-6. PMID: 23582727Free PMC Article
Acrodermatitis enteropathica.
Neldner KH, Hambidge KM, Walravens PA
Int J Dermatol 1978 Jun;17(5):380-7. doi: 10.1111/ijd.1978.17.5.380. PMID: 96035

Clinical prediction guides

Demographic and clinical characteristics of patients with zinc deficiency: analysis of a nationwide Japanese medical claims database.
Yokokawa H, Morita Y, Hamada I, Ohta Y, Fukui N, Makino N, Ohata E, Naito T
Sci Rep 2024 Feb 2;14(1):2791. doi: 10.1038/s41598-024-53202-0. PMID: 38307882Free PMC Article
Association of Zinc with Anemia.
Jeng SS, Chen YH
Nutrients 2022 Nov 20;14(22) doi: 10.3390/nu14224918. PMID: 36432604Free PMC Article
Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis.
Sanna A, Firinu D, Zavattari P, Valera P
Nutrients 2018 Jan 11;10(1) doi: 10.3390/nu10010068. PMID: 29324654Free PMC Article
Discovery of human zinc deficiency: its impact on human health and disease.
Prasad AS
Adv Nutr 2013 Mar 1;4(2):176-90. doi: 10.3945/an.112.003210. PMID: 23493534Free PMC Article
Zinc nutrition and HIV infection.
Kupka R, Fawzi W
Nutr Rev 2002 Mar;60(3):69-79. doi: 10.1301/00296640260042739. PMID: 11908743

Recent systematic reviews

Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases.
Chao HC
Nutrients 2023 Sep 22;15(19) doi: 10.3390/nu15194093. PMID: 37836377Free PMC Article
Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years.
Imdad A, Rogner J, Sherwani RN, Sidhu J, Regan A, Haykal MR, Tsistinas O, Smith A, Chan XHS, Mayo-Wilson E, Bhutta ZA
Cochrane Database Syst Rev 2023 Mar 30;3(3):CD009384. doi: 10.1002/14651858.CD009384.pub3. PMID: 36994923Free PMC Article
Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review.
Beserra JB, Morais JBS, Severo JS, Cruz KJC, de Oliveira ARS, Henriques GS, do Nascimento Marreiro D
Biol Trace Elem Res 2021 Nov;199(11):4092-4100. Epub 2021 Jan 7 doi: 10.1007/s12011-020-02562-5. PMID: 33409921
Zinc deficiency and febrile seizure: a systematic review and meta-analysis.
Heydarian F, Nakhaei AA, Majd HM, Bakhtiari E
Turk J Pediatr 2020;62(3):347-358. doi: 10.24953/turkjped.2020.03.001. PMID: 32558408
Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis.
Sanna A, Firinu D, Zavattari P, Valera P
Nutrients 2018 Jan 11;10(1) doi: 10.3390/nu10010068. PMID: 29324654Free PMC Article

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