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Acquired methemoglobinemia

MedGen UID:
473012
•Concept ID:
C0271905
•
Disease or Syndrome
Synonym: Acquired Methemoglobinemia
SNOMED CT: Acquired methemoglobinemia (295315008)

Definition

Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcquired methemoglobinemia

Professional guidelines

PubMed

Ascorbic acid for the treatment of methemoglobinemia: the experience of a large tertiary care pediatric hospital.
Rino PB, Scolnik D, Fustiñana A, Mitelpunkt A, Glatstein M
Am J Ther 2014 Jul-Aug;21(4):240-3. doi: 10.1097/MJT.0000000000000028. PMID: 24914501
Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use.
Taleb M, Ashraf Z, Valavoor S, Tinkel J
Am J Cardiovasc Drugs 2013 Oct;13(5):325-30. doi: 10.1007/s40256-013-0027-2. PMID: 23696166

Recent clinical studies

Etiology

Near-fatal pediatric methemoglobinemia secondary to intentional sodium nitrite ingestion.
Sajko N, Finn K, Hill J, Khaira GK, Duff JP, Jiwani F, Allain D, Oliva MA
Am J Emerg Med 2022 Sep;59:215.e1-215.e5. Epub 2022 May 31 doi: 10.1016/j.ajem.2022.05.051. PMID: 35691874
Methylene blue in management of COVID19.
Patidar V, Sharma A, Garg V, Tripathi AP, Dhaneriya S
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443513
Dapsone-induced methemoglobinemia in pediatrics post-renal transplant.
Hindka A, Huynh D, Verghese PS
Pediatr Transplant 2021 May;25(3):e13921. Epub 2020 Dec 6 doi: 10.1111/petr.13921. PMID: 33280223
Methemoglobinemia: Infants at risk.
Fossen Johnson S
Curr Probl Pediatr Adolesc Health Care 2019 Mar;49(3):57-67. Epub 2019 Apr 5 doi: 10.1016/j.cppeds.2019.03.002. PMID: 30956100
Benzocaine-induced methemoglobinemia: experience from a high-volume transesophageal echocardiography laboratory.
Novaro GM, Aronow HD, Militello MA, Garcia MJ, Sabik EM
J Am Soc Echocardiogr 2003 Feb;16(2):170-5. doi: 10.1067/mje.2003.5. PMID: 12574744

Diagnosis

Acquired methemoglobinemia induced by indoxacarb poisoning: a case report.
Braiek DB, Hidri R, Kaabi C, Zorgati H, Mighri I, Jazia RB, Kacem A, Ayachi J
Pan Afr Med J 2024;47:92. Epub 2024 Feb 27 doi: 10.11604/pamj.2024.47.92.34766. PMID: 38799189Free PMC Article
Central Cyanosis in Acquired Methemoglobinemia.
Das P, Singh G
N Engl J Med 2024 Apr 11;390(14):1311. doi: 10.1056/NEJMicm2304082. PMID: 38598797
Acquired Methemoglobinemia.
Warren OU, Blackwood B
N Engl J Med 2019 Sep 19;381(12):1158. doi: 10.1056/NEJMicm1816026. PMID: 31532963
Acquired methemoglobinemia revisited.
Trapp L, Will J
Dent Clin North Am 2010 Oct;54(4):665-75. Epub 2010 Aug 7 doi: 10.1016/j.cden.2010.06.007. PMID: 20831930
When brown and blue make red: a case of acquired methemoglobinemia.
Marinella MA
Heart Lung 2006 May-Jun;35(3):205-6. doi: 10.1016/j.hrtlng.2005.09.011. PMID: 16701115

Therapy

Near-fatal pediatric methemoglobinemia secondary to intentional sodium nitrite ingestion.
Sajko N, Finn K, Hill J, Khaira GK, Duff JP, Jiwani F, Allain D, Oliva MA
Am J Emerg Med 2022 Sep;59:215.e1-215.e5. Epub 2022 May 31 doi: 10.1016/j.ajem.2022.05.051. PMID: 35691874
Acquired Methemoglobinemia.
Warren OU, Blackwood B
N Engl J Med 2019 Sep 19;381(12):1158. doi: 10.1056/NEJMicm1816026. PMID: 31532963
Acquired methemoglobinemia revisited.
Trapp L, Will J
Dent Clin North Am 2010 Oct;54(4):665-75. Epub 2010 Aug 7 doi: 10.1016/j.cden.2010.06.007. PMID: 20831930
Acquired methemoglobinemia.
Geffner ME, Powars DR, Choctaw WT
West J Med 1981 Jan;134(1):7-10. PMID: 7210666Free PMC Article
Acquired methemoglobinemia and hemolytic anemia following excessive pyridium (phenazopyridine hydrochloride) ingestion.
Cohen BL, Bovasso GJ Jr
Clin Pediatr (Phila) 1971 Sep;10(9):537-40. doi: 10.1177/000992287101000912. PMID: 5095165

Prognosis

Methylene blue in management of COVID19.
Patidar V, Sharma A, Garg V, Tripathi AP, Dhaneriya S
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443513
Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia.
Kim YJ, Sohn CH, Ryoo SM, Ahn S, Seo DW, Lee YS, Lee JH, Oh BJ, Lim KS, Kim WY
Clin Toxicol (Phila) 2016 Aug;54(7):581-4. Epub 2016 May 12 doi: 10.1080/15563650.2016.1178759. PMID: 27412886
A rare case of acquired methemoglobinemia associated with alkaptonuria.
Isa Y, Nihei S, Irifukuhama Y, Ikeda T, Matsumoto H, Nagata K, Harayama N, Aibara K, Kamochi M
Intern Med 2014;53(16):1797-800. Epub 2014 Aug 15 doi: 10.2169/internalmedicine.53.1938. PMID: 25130113
Benzocaine-induced methemoglobinemia: experience from a high-volume transesophageal echocardiography laboratory.
Novaro GM, Aronow HD, Militello MA, Garcia MJ, Sabik EM
J Am Soc Echocardiogr 2003 Feb;16(2):170-5. doi: 10.1067/mje.2003.5. PMID: 12574744
Hypoxemia sans hypoxemia.
Saleem MA, McClung JA, Peterson SJ
Heart Dis 2000 Mar-Apr;2(2):116-7. PMID: 11728248

Clinical prediction guides

Methylene blue in management of COVID19.
Patidar V, Sharma A, Garg V, Tripathi AP, Dhaneriya S
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443513
Fatal methemoglobinemia: A case series highlighting a new trend in intentional sodium nitrite or sodium nitrate ingestion as a method of suicide.
Hickey TBM, MacNeil JA, Hansmeyer C, Pickup MJ
Forensic Sci Int 2021 Sep;326:110907. Epub 2021 Jul 15 doi: 10.1016/j.forsciint.2021.110907. PMID: 34298207
Protracted methemoglobinemia after phenazopyridine overdose in an infant.
Christensen CM, Farrar HC, Kearns GL
J Clin Pharmacol 1996 Feb;36(2):112-6. doi: 10.1002/j.1552-4604.1996.tb04175.x. PMID: 8852386

Recent systematic reviews

Acquired methemoglobinemia: A systematic review of reported cases.
Gao H, Basri R, Tran MH
Transfus Apher Sci 2022 Apr;61(2):103299. Epub 2021 Oct 27 doi: 10.1016/j.transci.2021.103299. PMID: 34740513

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