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Apnea of prematurity

MedGen UID:
473179
Concept ID:
C0475715
Pathologic Function
Synonyms: AOP; Apnea of Prematurity; apnea of prematurity
SNOMED CT: Apnea of prematurity (276544005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0034236
Monarch Initiative: MONDO:0020567
Orphanet: ORPHA99981

Definition

Recurrent episodes of apnea occurring in infants born less than 37 weeks of gestation, defined specifically as a pause of breathing for more than 15-20 s, or accompanied by oxygen desaturation (SpO2 not more than 80% for at least 4 s) and bradycardia (heart rate less than 2/3 of baseline for at least 4 s), in infants born less than 37 weeks of gestation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVApnea of prematurity
Follow this link to review classifications for Apnea of prematurity in Orphanet.

Professional guidelines

PubMed

Marques KA, Bruschettini M, Roehr CC, Davis PG, Fiander M, Soll R
Cochrane Database Syst Rev 2023 Oct 31;10(10):CD013830. doi: 10.1002/14651858.CD013830.pub2. PMID: 37905735Free PMC Article
Morton SU, Smith VC
Arch Dis Child Fetal Neonatal Ed 2016 Jul;101(4):F352-6. Epub 2016 Mar 22 doi: 10.1136/archdischild-2015-310228. PMID: 27010019
Zhao J, Gonzalez F, Mu D
Eur J Pediatr 2011 Sep;170(9):1097-105. Epub 2011 Feb 8 doi: 10.1007/s00431-011-1409-6. PMID: 21301866Free PMC Article

Recent clinical studies

Etiology

Bruschettini M, Brattström P, Russo C, Onland W, Davis PG, Soll R
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013873. doi: 10.1002/14651858.CD013873.pub2. PMID: 37040532Free PMC Article
Miao Y, Zhou Y, Zhao S, Liu W, Wang A, Zhang Y, Li Y, Jiang H
PLoS One 2022;17(9):e0274882. Epub 2022 Sep 19 doi: 10.1371/journal.pone.0274882. PMID: 36121807Free PMC Article
Martin RJ, Mitchell LJ, MacFarlane PM
Handb Clin Neurol 2022;189:43-52. doi: 10.1016/B978-0-323-91532-8.00010-0. PMID: 36031315Free PMC Article
Gentle SJ, Travers CP, Carlo WA
Curr Opin Pediatr 2018 Apr;30(2):177-181. doi: 10.1097/MOP.0000000000000588. PMID: 29346141
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity Trial Group
N Engl J Med 2006 May 18;354(20):2112-21. doi: 10.1056/NEJMoa054065. PMID: 16707748

Diagnosis

Erickson G, Dobson NR, Hunt CE
J Perinatol 2021 Sep;41(9):2111-2123. Epub 2021 Mar 12 doi: 10.1038/s41372-021-01010-z. PMID: 33712716Free PMC Article
Patrinos ME, Martin RJ
Semin Fetal Neonatal Med 2017 Aug;22(4):240-244. Epub 2017 Apr 21 doi: 10.1016/j.siny.2017.04.003. PMID: 28438477
Eichenwald EC; Committee on Fetus and Newborn, American Academy of Pediatrics
Pediatrics 2016 Jan;137(1) Epub 2015 Dec 1 doi: 10.1542/peds.2015-3757. PMID: 26628729
Di Fiore JM, Martin RJ, Gauda EB
Respir Physiol Neurobiol 2013 Nov 1;189(2):213-22. Epub 2013 May 28 doi: 10.1016/j.resp.2013.05.026. PMID: 23727228
Miller MJ, Martin RJ
Clin Perinatol 1992 Dec;19(4):789-808. PMID: 1464191

Therapy

Bruschettini M, Brattström P, Russo C, Onland W, Davis PG, Soll R
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013873. doi: 10.1002/14651858.CD013873.pub2. PMID: 37040532Free PMC Article
Miao Y, Zhou Y, Zhao S, Liu W, Wang A, Zhang Y, Li Y, Jiang H
PLoS One 2022;17(9):e0274882. Epub 2022 Sep 19 doi: 10.1371/journal.pone.0274882. PMID: 36121807Free PMC Article
Gentle SJ, Travers CP, Carlo WA
Curr Opin Pediatr 2018 Apr;30(2):177-181. doi: 10.1097/MOP.0000000000000588. PMID: 29346141
Martin RJ, Wilson CG
Compr Physiol 2012 Oct;2(4):2923-31. doi: 10.1002/cphy.c100021. PMID: 23720269
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity Trial Group
N Engl J Med 2006 May 18;354(20):2112-21. doi: 10.1056/NEJMoa054065. PMID: 16707748

Prognosis

Bhandari V, Gruen JR
Semin Perinatol 2015 Dec;39(8):568-73. Epub 2015 Oct 23 doi: 10.1053/j.semperi.2015.09.003. PMID: 26471062
Frenette E, Guilleminault C
Handb Clin Neurol 2013;112:857-60. doi: 10.1016/B978-0-444-52910-7.00006-4. PMID: 23622294
Martin RJ, Wilson CG
Compr Physiol 2012 Oct;2(4):2923-31. doi: 10.1002/cphy.c100021. PMID: 23720269
Mathew OP
J Perinatol 2011 May;31(5):302-10. Epub 2010 Dec 2 doi: 10.1038/jp.2010.126. PMID: 21127467
Poets CF
Sleep Med 2010 Aug;11(7):701-7. doi: 10.1016/j.sleep.2009.11.016. PMID: 20621558

Clinical prediction guides

Karlinski Vizentin V, Madeira de Sá Pacheco I, Fahel Vilas Bôas Azevêdo T, Florêncio de Mesquita C, Alvim Pereira R
Neonatology 2024;121(1):7-16. Epub 2023 Nov 21 doi: 10.1159/000534497. PMID: 37989113
Bruschettini M, Brattström P, Russo C, Onland W, Davis PG, Soll R
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013873. doi: 10.1002/14651858.CD013873.pub2. PMID: 37040532Free PMC Article
Fleiss B, Gressens P
Handb Clin Neurol 2019;162:315-328. doi: 10.1016/B978-0-444-64029-1.00015-1. PMID: 31324318
Vliegenthart RJ, Ten Hove CH, Onland W, van Kaam AH
Neonatology 2017;111(2):162-171. Epub 2016 Oct 20 doi: 10.1159/000448941. PMID: 27760427Free PMC Article
Poets CF
Sleep Med 2010 Aug;11(7):701-7. doi: 10.1016/j.sleep.2009.11.016. PMID: 20621558

Recent systematic reviews

Marques KA, Bruschettini M, Roehr CC, Davis PG, Fiander M, Soll R
Cochrane Database Syst Rev 2023 Oct 31;10(10):CD013830. doi: 10.1002/14651858.CD013830.pub2. PMID: 37905735Free PMC Article
Evans S, Avdic E, Pessano S, Fiander M, Soll R, Bruschettini M
Cochrane Database Syst Rev 2023 Oct 25;10(10):CD014145. doi: 10.1002/14651858.CD014145.pub2. PMID: 37877431Free PMC Article
Bruschettini M, Brattström P, Russo C, Onland W, Davis PG, Soll R
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013873. doi: 10.1002/14651858.CD013873.pub2. PMID: 37040532Free PMC Article
Miao Y, Zhou Y, Zhao S, Liu W, Wang A, Zhang Y, Li Y, Jiang H
PLoS One 2022;17(9):e0274882. Epub 2022 Sep 19 doi: 10.1371/journal.pone.0274882. PMID: 36121807Free PMC Article
Vliegenthart RJ, Ten Hove CH, Onland W, van Kaam AH
Neonatology 2017;111(2):162-171. Epub 2016 Oct 20 doi: 10.1159/000448941. PMID: 27760427Free PMC Article

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