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Drug Induced Thrombocytopenia

MedGen UID:
473522
•Concept ID:
C2063616
•
Pathologic Function
Synonym: DITP

Definition

Thrombocytopenia caused by ingested or injected drugs. It may be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug Induced Thrombocytopenia

Professional guidelines

PubMed

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Severe drug-induced thrombocytopenia after treatment with trastuzumab but not with lapatinib.
Cathomas R, von Moos R
Ann Oncol 2009 Sep;20(9):1606-1607. Epub 2009 Jul 21 doi: 10.1093/annonc/mdp370. PMID: 19622591
Treatment of drug-induced thrombocytopenia.
Zondor SD, George JN, Medina PJ
Expert Opin Drug Saf 2002 Jul;1(2):173-80. doi: 10.1517/14740338.1.2.173. PMID: 12904151

Recent clinical studies

Etiology

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia.
Sun S, Urbanus RT, Ten Cate H, de Groot PG, de Laat B, Heemskerk JWM, Roest M
Cells 2021 Dec 1;10(12) doi: 10.3390/cells10123386. PMID: 34943895Free PMC Article
Drug-Induced Thrombocytopenia: Mechanisms and Laboratory Diagnostics.
Danese E, Montagnana M, Favaloro EJ, Lippi G
Semin Thromb Hemost 2020 Apr;46(3):264-274. Epub 2019 Sep 28 doi: 10.1055/s-0039-1697930. PMID: 31563127
Drug-induced immune thrombocytopenia.
Chong BH, Choi PY, Khachigian L, Perdomo J
Hematol Oncol Clin North Am 2013 Jun;27(3):521-40. Epub 2013 Apr 9 doi: 10.1016/j.hoc.2013.02.003. PMID: 23714310
Drug-induced thrombocytopenia.
Kenney B, Stack G
Arch Pathol Lab Med 2009 Feb;133(2):309-14. doi: 10.5858/133.2.309. PMID: 19195976

Diagnosis

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Drug-Induced Thrombocytopenia: Mechanisms and Laboratory Diagnostics.
Danese E, Montagnana M, Favaloro EJ, Lippi G
Semin Thromb Hemost 2020 Apr;46(3):264-274. Epub 2019 Sep 28 doi: 10.1055/s-0039-1697930. PMID: 31563127
Drug-induced thrombocytopenia.
Miescher PA, Graf J
Clin Haematol 1980 Oct;9(3):505-19. PMID: 7004684
Drug-induced thrombocytopenia.
Miescher PA
Semin Hematol 1973 Oct;10(4):311-25. PMID: 4610752
Drug-induced thrombocytopenia.
Gynn TN, Messmore HL, Friedman IA
Med Clin North Am 1972 Jan;56(1):65-79. doi: 10.1016/s0025-7125(16)32423-3. PMID: 4550194

Therapy

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Idiosyncratic drug-induced thrombocytopenia.
Murphy WG, Kelton JG
Curr Stud Hematol Blood Transfus 1988;(54):71-88. PMID: 2964994
Drug-induced thrombocytopenia.
Miescher PA, Graf J
Clin Haematol 1980 Oct;9(3):505-19. PMID: 7004684
Drug-induced thrombocytopenia.
Miescher PA
Semin Hematol 1973 Oct;10(4):311-25. PMID: 4610752
Drug-induced thrombocytopenia.
Gynn TN, Messmore HL, Friedman IA
Med Clin North Am 1972 Jan;56(1):65-79. doi: 10.1016/s0025-7125(16)32423-3. PMID: 4550194

Prognosis

Perioperative Approach to Anticoagulants and Hematologic Disorders.
Kim J, Huh R, Jaffer AK
Anesthesiol Clin 2016 Mar;34(1):101-25. doi: 10.1016/j.anclin.2015.10.010. PMID: 26927742
Drug-induced immune thrombocytopenia.
Kam T, Alexander M
J Pharm Pract 2014 Oct;27(5):430-9. Epub 2014 Aug 17 doi: 10.1177/0897190014546099. PMID: 25134884
Drug-induced immune thrombocytopenia.
Chong BH, Choi PY, Khachigian L, Perdomo J
Hematol Oncol Clin North Am 2013 Jun;27(3):521-40. Epub 2013 Apr 9 doi: 10.1016/j.hoc.2013.02.003. PMID: 23714310
Drug-induced thrombocytopenia.
Kenney B, Stack G
Arch Pathol Lab Med 2009 Feb;133(2):309-14. doi: 10.5858/133.2.309. PMID: 19195976
Quinine toxicity.
Bateman DN, Dyson EH
Adverse Drug React Acute Poisoning Rev 1986 Winter;5(4):215-33. PMID: 3548270

Clinical prediction guides

Anti-tubercular therapy (ATT) induced thrombocytopenia: A systematic review.
Kaur A, Bhandari RK, Rohilla R, Shafiq N, Prakash G, Mothsara C, Pandey AK, Malhotra S
Indian J Tuberc 2023 Oct;70(4):489-496. Epub 2023 Apr 29 doi: 10.1016/j.ijtb.2023.04.029. PMID: 37968056
Impact of Venlafaxine on Platelet Count and Activity-Case Report and Narrative Review.
Smolarczyk-Kosowska J, Kosowski M, Kunert Ł, Filipczyk K, Wojciechowski M, Piegza M, Gorczyca P, Okopień B, Pudlo R
Medicina (Kaunas) 2022 Apr 30;58(5) doi: 10.3390/medicina58050626. PMID: 35630043Free PMC Article
Roxithromycin-Associated Acute Thrombocytopenia.
Rossi M, Capecchi M, Lazzerini PE
Am J Case Rep 2021 Jun 30;22:e932039. doi: 10.12659/AJCR.932039. PMID: 34188012Free PMC Article
Perioperative Approach to Anticoagulants and Hematologic Disorders.
Kim J, Huh R, Jaffer AK
Anesthesiol Clin 2016 Mar;34(1):101-25. doi: 10.1016/j.anclin.2015.10.010. PMID: 26927742
Quinine toxicity.
Bateman DN, Dyson EH
Adverse Drug React Acute Poisoning Rev 1986 Winter;5(4):215-33. PMID: 3548270

Recent systematic reviews

Anti-tubercular therapy (ATT) induced thrombocytopenia: A systematic review.
Kaur A, Bhandari RK, Rohilla R, Shafiq N, Prakash G, Mothsara C, Pandey AK, Malhotra S
Indian J Tuberc 2023 Oct;70(4):489-496. Epub 2023 Apr 29 doi: 10.1016/j.ijtb.2023.04.029. PMID: 37968056
Diversity and severity of adverse reactions to quinine: A systematic review.
Liles NW, Page EE, Liles AL, Vesely SK, Raskob GE, George JN
Am J Hematol 2016 May;91(5):461-6. Epub 2016 Apr 4 doi: 10.1002/ajh.24314. PMID: 26822544
Linezolid-induced thrombocytopenia in impaired renal function: is it time for a dose adjustment? A case report and review of literature.
Cossu AP, Musu M, Mura P, De Giudici LM, Finco G
Eur J Clin Pharmacol 2014 Jan;70(1):23-8. doi: 10.1007/s00228-013-1585-6. PMID: 24022332
Drug-induced thrombocytopenia.
Rizvi MA, Shah SR, Raskob GE, George JN
Curr Opin Hematol 1999 Sep;6(5):349-53. doi: 10.1097/00062752-199909000-00013. PMID: 10468152
Drug-induced thrombocytopenia: a systematic review of published case reports.
George JN, Raskob GE, Shah SR, Rizvi MA, Hamilton SA, Osborne S, Vondracek T
Ann Intern Med 1998 Dec 1;129(11):886-90. doi: 10.7326/0003-4819-129-11_part_1-199812010-00009. PMID: 9867731

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