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High Grade Appendix Mucinous Adenocarcinoma

MedGen UID:
474399
Concept ID:
C3272766
Neoplastic Process

Definition

A mucinous adenocarcinoma that arises from the appendix. The malignant cells are numerous and exhibit high grade dysplasia. It may be associated with pseudomyxoma peritonei, but unlike the low grade mucinous neoplasm, it invades other organs and metastasizes to distant anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Appendix Mucinous Adenocarcinoma

Professional guidelines

PubMed

Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Mittal R, Chandramohan A, Moran B
Int J Hyperthermia 2017 Aug;33(5):511-519. doi: 10.1080/02656736.2017.1310938. PMID: 28540829

Recent clinical studies

Etiology

Gonzalez RS, Carr NJ, Liao H, Pai RK, Agostini-Vulaj D, Misdraji J
Arch Pathol Lab Med 2022 Dec 1;146(12):1471-1478. doi: 10.5858/arpa.2021-0430-OA. PMID: 35472721
Liao X, Vavinskaya V, Sun K, Hao Y, Li X, Valasek M, Xu R, Polydorides AD, Houldsworth J, Harpaz N
Histopathology 2020 Feb;76(3):461-469. Epub 2019 Dec 23 doi: 10.1111/his.13986. PMID: 31491041
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Tirumani SH, Fraser-Hill M, Auer R, Shabana W, Walsh C, Lee F, Ryan JG
Cancer Imaging 2013 Feb 22;13(1):14-25. doi: 10.1102/1470-7330.2013.0003. PMID: 23439060Free PMC Article

Diagnosis

Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Mittal R, Chandramohan A, Moran B
Int J Hyperthermia 2017 Aug;33(5):511-519. doi: 10.1080/02656736.2017.1310938. PMID: 28540829
Tirumani SH, Fraser-Hill M, Auer R, Shabana W, Walsh C, Lee F, Ryan JG
Cancer Imaging 2013 Feb 22;13(1):14-25. doi: 10.1102/1470-7330.2013.0003. PMID: 23439060Free PMC Article

Therapy

Lopez-Ramirez F, Gushchin V, Sittig M, King MC, Baron E, Nikiforchin A, Nieroda C, Sardi A
Ann Surg Oncol 2022 Jun;29(6):3390-3401. Epub 2022 Feb 8 doi: 10.1245/s10434-021-11233-1. PMID: 35133518
Copur M, Cushman-Vokoun A, Padussis J, Whitney W, Schroeder C, Herold D, Lintel N, Horn A
Oncology (Williston Park) 2021 Jun 23;35(6):335-340. doi: 10.46883/ONC.2021.3506.0335. PMID: 34161053
Baratti D, Kusamura S, Milione M, Pietrantonio F, Caporale M, Guaglio M, Deraco M
Ann Surg Oncol 2016 Dec;23(13):4222-4230. Epub 2016 Jun 28 doi: 10.1245/s10434-016-5350-9. PMID: 27352203
Fallis SA, Moran BJ
J BUON 2015 May;20 Suppl 1:S47-55. PMID: 26051332
Topkan E, Polat Y, Karaoglu A
Tumori 2008 Jul-Aug;94(4):596-9. doi: 10.1177/030089160809400426. PMID: 18822701

Prognosis

Bell PD
Semin Diagn Pathol 2024 Sep;41(5):213-221. Epub 2024 Aug 16 doi: 10.1053/j.semdp.2024.08.005. PMID: 39214725
Gonzalez RS, Carr NJ, Liao H, Pai RK, Agostini-Vulaj D, Misdraji J
Arch Pathol Lab Med 2022 Dec 1;146(12):1471-1478. doi: 10.5858/arpa.2021-0430-OA. PMID: 35472721
Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195
Fallis SA, Moran BJ
J BUON 2015 May;20 Suppl 1:S47-55. PMID: 26051332
Tirumani SH, Fraser-Hill M, Auer R, Shabana W, Walsh C, Lee F, Ryan JG
Cancer Imaging 2013 Feb 22;13(1):14-25. doi: 10.1102/1470-7330.2013.0003. PMID: 23439060Free PMC Article

Clinical prediction guides

McClelland PH, Gregory SN, Nah SK, Hernandez JM, Davis JL, Blakely AM
Ann Surg Oncol 2024 Sep;31(9):6237-6251. Epub 2024 Jun 14 doi: 10.1245/s10434-024-15526-z. PMID: 38874874Free PMC Article
Lopez-Ramirez F, Gushchin V, Sittig M, King MC, Baron E, Nikiforchin A, Nieroda C, Sardi A
Ann Surg Oncol 2022 Jun;29(6):3390-3401. Epub 2022 Feb 8 doi: 10.1245/s10434-021-11233-1. PMID: 35133518
Orr CE, Yantiss RK
Pathology 2022 Mar;54(2):167-176. Epub 2021 Nov 23 doi: 10.1016/j.pathol.2021.09.003. PMID: 34836648
Hissong E, Yantiss RK
Am J Surg Pathol 2022 Jan 1;46(1):e27-e42. doi: 10.1097/PAS.0000000000001662. PMID: 33417324
Saarinen L, Nummela P, Leinonen H, Heiskanen A, Thiel A, Haglund C, Lepistö A, Satomaa T, Hautaniemi S, Ristimäki A
Mol Cell Proteomics 2018 Nov;17(11):2107-2118. Epub 2018 Aug 2 doi: 10.1074/mcp.RA118.000615. PMID: 30072579Free PMC Article

Recent systematic reviews

Floriano I, Silvinato A, Reis JC, Cafalli C, Bernardo WM
Clinics (Sao Paulo) 2022;77:100039. Epub 2022 May 13 doi: 10.1016/j.clinsp.2022.100039. PMID: 35576869Free PMC Article
Martín-Román L, Lozano P, Vásquez W, Palencia N, Gómez Y, Fernández-Aceñero MJ, González-Bayón L
BJS Open 2021 Jul 6;5(4) doi: 10.1093/bjsopen/zrab059. PMID: 34355239Free PMC Article

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