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Colon Serrated Adenocarcinoma

MedGen UID:: 474443
•Concept ID:: C3272810
•: Neoplastic Process

Definition

A rare, invasive colon adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVColon Serrated Adenocarcinoma

Neoplasm
- Epithelial neoplasm
  - Carcinoma
    - Adenocarcinoma
      - Adenocarcinoma of the large intestine
        Colon adenocarcinoma
        Colon Serrated Adenocarcinoma

Professional guidelines

PubMed

Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp.

Boylan KE, Kanth P, Delker D, Hazel MW, Boucher KM, Affolter K, Clayton F, Evason KJ, Jedrzkiewicz J, Pletneva M, Samowitz W, Swanson E, Bronner MP
Hum Pathol 2023 Jul;137:25-35. Epub 2023 Apr 11 doi: 10.1016/j.humpath.2023.04.002. PMID: 37044202 Free PMC Article

Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.

Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239

UK guidance for the pathological reporting of serrated lesions of the colorectum.

Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843

See all (8)

Recent clinical studies

Etiology

The Frontiers of Serrated Polyps.

Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859

Yield of screening colonoscopy in renal transplant candidates.

AlAmeel T, Bseiso B, AlBugami MM, AlMomen S, Roth LS
Can J Gastroenterol Hepatol 2015 Nov-Dec;29(8):423-6. Epub 2015 Jun 12 doi: 10.1155/2015/823835. PMID: 26069893 Free PMC Article

Serrated pathway in colorectal carcinogenesis.

Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599 Free PMC Article

Serrated adenomas.

De Jesus-Monge WE, Gonzalez-Keelan C, Cruz-Correa M
Curr Gastroenterol Rep 2009 Oct;11(5):420-7. doi: 10.1007/s11894-009-0063-x. PMID: 19765371

Colorectal polyps and other precursor lesions. Need for an expanded view.

Burgart LJ
Gastroenterol Clin North Am 2002 Dec;31(4):959-70. doi: 10.1016/s0889-8553(02)00056-0. PMID: 12489272

See all (125)

Diagnosis

The Frontiers of Serrated Polyps.

Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859

The histomorphological and molecular landscape of colorectal adenomas and serrated lesions.

Galuppini F, Fassan M, Mastracci L, Gafà R, Lo Mele M, Lazzi S, Remo A, Parente P, D'Amuri A, Mescoli C, Tatangelo F, Lanza G
Pathologica 2021 Jun;113(3):218-229. doi: 10.32074/1591-951X-270. PMID: 34294939 Free PMC Article

Endoscopic Assessment of the Malignant Potential of the Nonpolypoid (Flat and Depressed) Colorectal Neoplasms: Thinking Fast, and Slow.

Asokkumar R, Malvar C, Nguyen-Vu T, Sanduleanu S, Kaltenbach T, Soetikno R
Gastrointest Endosc Clin N Am 2019 Oct;29(4):613-628. Epub 2019 Jul 25 doi: 10.1016/j.giec.2019.06.006. PMID: 31445686

The pathology of bowel cancer screening.

Loughrey MB, Shepherd NA
Histopathology 2015 Jan;66(1):66-77. doi: 10.1111/his.12530. PMID: 25123305

Serrated adenomas.

De Jesus-Monge WE, Gonzalez-Keelan C, Cruz-Correa M
Curr Gastroenterol Rep 2009 Oct;11(5):420-7. doi: 10.1007/s11894-009-0063-x. PMID: 19765371

See all (91)

Therapy

Endoluminal management of colon perforations during advanced endoscopic procedures.

Ozgur I, Yilmaz S, Bhatt A, Holubar SD, Steele SR, Gorgun E
Surgery 2023 Mar;173(3):687-692. Epub 2022 Oct 18 doi: 10.1016/j.surg.2022.07.040. PMID: 36266121

Significance of serrated epithelial change in inflammatory bowel disease.

Batts KP, Atwaibi M, Weinberg DI, McCabe RP
Postgrad Med 2021 Jan;133(1):66-70. Epub 2020 Sep 29 doi: 10.1080/00325481.2020.1802138. PMID: 32746680

Timed screening colonoscopy: a randomized trial of two colonoscopic withdrawal techniques.

Coghlan E, Laferrere L, Zenon E, Marini JM, Rainero G, San Roman A, Posadas Martinez ML, Nadales A
Surg Endosc 2020 Mar;34(3):1200-1205. Epub 2019 May 29 doi: 10.1007/s00464-019-06873-0. PMID: 31144121

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma.

Wang Y, Huang D, Chen KY, Cui M, Wang W, Huang X, Awadellah A, Li Q, Friedman A, Xin WW, Di Martino L, Cominelli F, Miron A, Chan R, Fox JG, Xu Y, Shen X, Kalady MF, Markowitz S, Maillard I, Lowe JB, Xin W, Zhou L
Gastroenterology 2017 Jan;152(1):193-205.e10. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.004. PMID: 27639802 Free PMC Article

Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.

Missiaglia E, Jacobs B, D'Ario G, Di Narzo AF, Soneson C, Budinska E, Popovici V, Vecchione L, Gerster S, Yan P, Roth AD, Klingbiel D, Bosman FT, Delorenzi M, Tejpar S
Ann Oncol 2014 Oct;25(10):1995-2001. Epub 2014 Jul 23 doi: 10.1093/annonc/mdu275. PMID: 25057166

See all (12)

Prognosis

Clinical, pathological genetics and intratumoral immune milieu of serrated adenocarcinoma of the colon.

Yılmaz O, Crabbe A, Neyaz A, Pankaj A, Lee SH, Hosseini S, Rickelt S, Cerda S, Zhao Q, Leijsen L, Dineaux A, Shroff SG, Crotty R, Zhang ML, Yilmaz OH, Patil DT, Berger D, Deshpande V
Histopathology 2022 Sep;81(3):380-388. Epub 2022 Jul 20 doi: 10.1111/his.14719. PMID: 35789111

The Frontiers of Serrated Polyps.

Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859

Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.

Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239

Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.

Lee CT, Huang YC, Hung LY, Chow NH, Su PF, Ho CL, Tsai HW, Chen YL, Lin SC, Lin BW, Lin PC, Lee JC
Oncotarget 2017 May 23;8(21):35165-35175. doi: 10.18632/oncotarget.16815. PMID: 28422723 Free PMC Article

Serrated pathway in colorectal carcinogenesis.

Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599 Free PMC Article

See all (64)

Clinical prediction guides

The Frontiers of Serrated Polyps.

Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859

Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.

Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239

Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.

UK guidance for the pathological reporting of serrated lesions of the colorectum.

Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843

Synchronous colorectal cancer: clinical, pathological and molecular implications.

Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471 Free PMC Article

See all (66)