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Lymphocyte-Rich Hepatocellular Carcinoma

MedGen UID:
474665
•Concept ID:
C3273032
•
Neoplastic Process
Synonym: Lymphoepithelioma-Like Hepatocellular Carcinoma

Definition

A rare type of hepatocellular carcinoma characterized by the presence of pleomorphic malignant cells that are intermixed with lymphocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphocyte-Rich Hepatocellular Carcinoma

Recent clinical studies

Etiology

Clinicopathologic features and tumor immune microenvironment of lymphocyte-rich hepatocellular carcinoma.
Zhang YW, Zhao C, Su BJ, Lin WZ, Liu WM, Liang J, Shao CK, Cheng N, Chen JN
Ann Diagn Pathol 2024 Dec;73:152382. Epub 2024 Oct 10 doi: 10.1016/j.anndiagpath.2024.152382. PMID: 39471591

Therapy

Clinicopathologic features and tumor immune microenvironment of lymphocyte-rich hepatocellular carcinoma.
Zhang YW, Zhao C, Su BJ, Lin WZ, Liu WM, Liang J, Shao CK, Cheng N, Chen JN
Ann Diagn Pathol 2024 Dec;73:152382. Epub 2024 Oct 10 doi: 10.1016/j.anndiagpath.2024.152382. PMID: 39471591

Prognosis

Clinicopathologic features and tumor immune microenvironment of lymphocyte-rich hepatocellular carcinoma.
Zhang YW, Zhao C, Su BJ, Lin WZ, Liu WM, Liang J, Shao CK, Cheng N, Chen JN
Ann Diagn Pathol 2024 Dec;73:152382. Epub 2024 Oct 10 doi: 10.1016/j.anndiagpath.2024.152382. PMID: 39471591
Characterization of lymphocyte-rich hepatocellular carcinoma and the prognostic role of tertiary lymphoid structures.
Ahn B, Ahn HS, Shin J, Jun E, Koh EY, Ryu YM, Kim SY, Sung CO, Shim JH, Hong J, Kim K, Kang HJ
Liver Int 2024 May;44(5):1202-1218. Epub 2024 Feb 16 doi: 10.1111/liv.15865. PMID: 38363048
Clinicopathological characteristics and molecular analysis of lymphocyte-rich hepatocellular carcinoma.
Tsutsui K, Nakayama M, Ogasawara S, Akiba J, Kondo R, Mihara Y, Yano Y, Mizuochi S, Kinjo Y, Murotani K, Yano H
Hum Pathol 2023 Nov;141:43-53. Epub 2023 Sep 22 doi: 10.1016/j.humpath.2023.09.004. PMID: 37742944
Frequent expression of PD-L1 in lymphocyte-rich hepatocellular carcinoma: A report of 4 cases.
Vij M, Veerankutty FH, Raju LP, Gowrishankar G, Rajalingam R, Jothimani D, Kaliamoorthy I, Rammohan A, Rela M
Ann Diagn Pathol 2023 Oct;66:152172. Epub 2023 Jun 17 doi: 10.1016/j.anndiagpath.2023.152172. PMID: 37348413

Clinical prediction guides

Clinicopathologic features and tumor immune microenvironment of lymphocyte-rich hepatocellular carcinoma.
Zhang YW, Zhao C, Su BJ, Lin WZ, Liu WM, Liang J, Shao CK, Cheng N, Chen JN
Ann Diagn Pathol 2024 Dec;73:152382. Epub 2024 Oct 10 doi: 10.1016/j.anndiagpath.2024.152382. PMID: 39471591
Characterization of lymphocyte-rich hepatocellular carcinoma and the prognostic role of tertiary lymphoid structures.
Ahn B, Ahn HS, Shin J, Jun E, Koh EY, Ryu YM, Kim SY, Sung CO, Shim JH, Hong J, Kim K, Kang HJ
Liver Int 2024 May;44(5):1202-1218. Epub 2024 Feb 16 doi: 10.1111/liv.15865. PMID: 38363048
Clinicopathological characteristics and molecular analysis of lymphocyte-rich hepatocellular carcinoma.
Tsutsui K, Nakayama M, Ogasawara S, Akiba J, Kondo R, Mihara Y, Yano Y, Mizuochi S, Kinjo Y, Murotani K, Yano H
Hum Pathol 2023 Nov;141:43-53. Epub 2023 Sep 22 doi: 10.1016/j.humpath.2023.09.004. PMID: 37742944
Frequent expression of PD-L1 in lymphocyte-rich hepatocellular carcinoma: A report of 4 cases.
Vij M, Veerankutty FH, Raju LP, Gowrishankar G, Rajalingam R, Jothimani D, Kaliamoorthy I, Rammohan A, Rela M
Ann Diagn Pathol 2023 Oct;66:152172. Epub 2023 Jun 17 doi: 10.1016/j.anndiagpath.2023.152172. PMID: 37348413

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