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Well Differentiated Hepatocellular Carcinoma

MedGen UID:
474666
•Concept ID:
C3273033
•
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns. It is usually associated with small tumors and an early stage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Applying criteria for hepatocellular neoplasm of uncertain malignant potential reclassifies more than half of hepatocellular adenomas.
Larson BK, Guindi M
Ann Diagn Pathol 2021 Dec;55:151833. Epub 2021 Sep 25 doi: 10.1016/j.anndiagpath.2021.151833. PMID: 34597957
Hepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteria.
Deniz K, Umetsu SE, Ferrell L, Yılmaz F, Güllüoğlu M, Sağol Ö, Doğusoy GB, Kırımlıoğlu H, Turhan N, Doran F, Kepil N, Çelikel ÇA, Nart D, Özgüven BY, Ceyran B, Karadağ N, Kır G, Erden E, Yılmaz G, Akyol G
Histopathology 2021 Jul;79(1):23-33. Epub 2021 Apr 12 doi: 10.1111/his.14330. PMID: 33406290
Differential diagnosis of hepatocellular nodular lesions.
Hytiroglou P, Theise ND
Semin Diagn Pathol 1998 Nov;15(4):285-99. PMID: 9845429

Recent clinical studies

Etiology

Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma.
Roncalli M, Sciarra A, Tommaso LD
Clin Mol Hepatol 2016 Jun;22(2):199-211. Epub 2016 May 18 doi: 10.3350/cmh.2016.0101. PMID: 27189732Free PMC Article
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269
Well differentiated hepatocellular carcinoma metastasizing to jaw and oral cavity within six months of primary diagnosis.
Afroze N, Soomro IN, Pervez S, Kayani N, Hasan SH
J Pak Med Assoc 1998 Jul;48(7):219-20. PMID: 10067029

Diagnosis

Evaluating Liver Biopsies with Well-Differentiated Hepatocellular Lesions.
Umetsu SE, Kakar S
Surg Pathol Clin 2023 Sep;16(3):581-598. Epub 2023 Jun 9 doi: 10.1016/j.path.2023.04.011. PMID: 37536890
Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Clinicopathologic analysis of the simple nodular type of well-differentiated hepatocellular carcinoma with extensive peliotic change.
Nomura Y, Nakashima O, Kumabe T, Akiba J, Ogasawara S, Kage M, Kinoshita H, Yano H
J Gastroenterol Hepatol 2014;29(7):1494-99. doi: 10.1111/jgh.12565. PMID: 25587618
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Therapy

A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study.
Wang Z, Yao J, Jing X, Li K, Lu S, Yang H, Ding H, Li K, Cheng W, He G, Jiang T, Liu F, Yu J, Han Z, Cheng Z, Tan S, Wang Z, Qi E, Wang S, Zhang Y, Li L, Dong X, Liang P, Yu X
Abdom Radiol (NY) 2024 Oct;49(10):3427-3437. Epub 2024 May 14 doi: 10.1007/s00261-024-04253-4. PMID: 38744698
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Acute tumor lysis syndrome after transarterial chemoembolization for well-differentiated hepatocellular carcinoma with neuroendocrine features.
Wang K, Chen Z
Onkologie 2010;33(10):532-5. Epub 2010 Sep 10 doi: 10.1159/000319695. PMID: 20926901
Hepatocellular carcinoma and oral contraceptives.
Henderson BE, Preston-Martin S, Edmondson HA, Peters RL, Pike MC
Br J Cancer 1983 Sep;48(3):437-40. doi: 10.1038/bjc.1983.210. PMID: 6311235Free PMC Article
Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives.
Davis M, Portmann B, Searle M, Wright R, Williams R
Br Med J 1975 Nov 29;4(5995):496-8. doi: 10.1136/bmj.4.5995.496. PMID: 172187Free PMC Article

Prognosis

Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.
Zhao S, Su G, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X
Technol Cancer Res Treat 2017 Dec;16(6):1092-1101. Epub 2017 Sep 25 doi: 10.1177/1533034617732426. PMID: 29332450Free PMC Article
Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475
Well differentiated hepatocellular carcinoma metastasizing to jaw and oral cavity within six months of primary diagnosis.
Afroze N, Soomro IN, Pervez S, Kayani N, Hasan SH
J Pak Med Assoc 1998 Jul;48(7):219-20. PMID: 10067029

Clinical prediction guides

Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475
Atypical large well-differentiated hepatocellular carcinoma with benign nature: a new clinical entity.
Kudo M
Intervirology 2004;47(3-5):227-37. doi: 10.1159/000078475. PMID: 15383732
Hyaline globules and intracellular lumina in a hepatocellular carcinoma.
An T, Ghatak N, Kastner R, Kay S, Lee HM
Am J Clin Pathol 1983 Mar;79(3):392-6. doi: 10.1093/ajcp/79.3.392. PMID: 6299097

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