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Gallbladder Adenocarcinoma, Biliary Type

MedGen UID:
474746
•Concept ID:
C3273113
•
Neoplastic Process

Definition

A well or moderately differentiated adenocarcinoma that arises from the gallbladder. It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands. Intestinal differentiation may be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Adenocarcinoma, Biliary Type

Professional guidelines

PubMed

Intraductal tubulopapillary neoplasms of the bile ducts: identity, clinicopathologic characteristics, and differential diagnosis of a distinct entity among intraductal tumors.
Pehlivanoglu B, Adsay V
Hum Pathol 2023 Feb;132:12-19. Epub 2022 Aug 5 doi: 10.1016/j.humpath.2022.07.019. PMID: 35934108
A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice.
Xu X, Li J, Wu J, Zhu R, Ji W
Cardiovasc Intervent Radiol 2018 Feb;41(2):206-217. Epub 2017 Oct 26 doi: 10.1007/s00270-017-1827-6. PMID: 29075881
Biliary tract malignancies: a population-based study on incidence, prognosis and management of patients.
Juliusson G, Jonasson JG, Jonsdottir SB, Garcia HG, Olafsdottir E, Möller PH, Björnsson ES
Scand J Gastroenterol 2016 Dec;51(12):1520-1525. Epub 2016 Aug 24 doi: 10.1080/00365521.2016.1218538. PMID: 27553174

Recent clinical studies

Etiology

Comparison of clinicopathological characteristics of mucinous adenocarcinoma and conventional adenocarcinoma of gallbladder.
Zou RQ, Hu HJ, Liu F, Lv TR, Wang JK, Regmi P, Li FY
Asian J Surg 2023 Jan;46(1):283-290. Epub 2022 Apr 11 doi: 10.1016/j.asjsur.2022.03.094. PMID: 35422386
Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Current controversies in cholangiocarcinoma.
Hoyos S, Navas MC, Restrepo JC, Botero RC
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1461-1467. Epub 2017 Jul 26 doi: 10.1016/j.bbadis.2017.07.027. PMID: 28756216
Histological phenotype is correlated with the wall-invasion pattern of gallbladder adenocarcinoma.
Toba T, Kijima H, Hakamada K, Igarashi Y
Biomed Res 2014;35(5):295-302. doi: 10.2220/biomedres.35.295. PMID: 25355436

Diagnosis

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
ABCB4 Gene Aberrations in Human Liver Disease: An Evolving Spectrum.
Reichert MC, Lammert F
Semin Liver Dis 2018 Nov;38(4):299-307. Epub 2018 Oct 24 doi: 10.1055/s-0038-1667299. PMID: 30357767
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
J Hepatol 2018 May;68(5):959-969. Epub 2018 Jan 31 doi: 10.1016/j.jhep.2018.01.009. PMID: 29360550
Hepatobiliary cancers, version 2.2014.
Benson AB 3rd, D'Angelica MI, Abrams TA, Are C, Bloomston PM, Chang DT, Clary BM, Covey AM, Ensminger WD, Iyer R, Kelley RK, Linehan D, Malafa MP, Meranze SG, Park JO, Pawlik T, Posey JA, Scaife C, Schefter T, Sigurdson ER, Tian GG, Vauthey JN, Venook AP, Yen Y, Zhu AX, Hoffmann KG, McMillian NR, Sundar H
J Natl Compr Canc Netw 2014 Aug;12(8):1152-82. doi: 10.6004/jnccn.2014.0112. PMID: 25099447
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

Brightline-2: a phase IIa/IIb trial of brigimadlin (BI 907828) in advanced biliary tract cancer, pancreatic ductal adenocarcinoma or other solid tumors.
Yoo C, Lamarca A, Choi HJ, Vogel A, Pishvaian MJ, Goyal L, Ueno M, Märten A, Teufel M, Geng L, Morizane C
Future Oncol 2024;20(16):1069-1077. Epub 2024 Jan 12 doi: 10.2217/fon-2023-0963. PMID: 38214149
Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Covered and uncovered biliary metal stents provide similar relief of biliary obstruction during neoadjuvant therapy in pancreatic cancer: a randomized trial.
Seo DW, Sherman S, Dua KS, Slivka A, Roy A, Costamagna G, Deviere J, Peetermans J, Rousseau M, Nakai Y, Isayama H, Kozarek R; Biliary SEMS During Neoadjuvant Therapy Study Group
Gastrointest Endosc 2019 Oct;90(4):602-612.e4. Epub 2019 Jul 2 doi: 10.1016/j.gie.2019.06.032. PMID: 31276674
Current controversies in cholangiocarcinoma.
Hoyos S, Navas MC, Restrepo JC, Botero RC
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1461-1467. Epub 2017 Jul 26 doi: 10.1016/j.bbadis.2017.07.027. PMID: 28756216
Hepatobiliary cancers, version 2.2014.
Benson AB 3rd, D'Angelica MI, Abrams TA, Are C, Bloomston PM, Chang DT, Clary BM, Covey AM, Ensminger WD, Iyer R, Kelley RK, Linehan D, Malafa MP, Meranze SG, Park JO, Pawlik T, Posey JA, Scaife C, Schefter T, Sigurdson ER, Tian GG, Vauthey JN, Venook AP, Yen Y, Zhu AX, Hoffmann KG, McMillian NR, Sundar H
J Natl Compr Canc Netw 2014 Aug;12(8):1152-82. doi: 10.6004/jnccn.2014.0112. PMID: 25099447

Prognosis

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
J Hepatol 2018 May;68(5):959-969. Epub 2018 Jan 31 doi: 10.1016/j.jhep.2018.01.009. PMID: 29360550
Current controversies in cholangiocarcinoma.
Hoyos S, Navas MC, Restrepo JC, Botero RC
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1461-1467. Epub 2017 Jul 26 doi: 10.1016/j.bbadis.2017.07.027. PMID: 28756216
Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier.
Song Y, Boerner T, Drill E, Shin P, Kumar S, Sigel C, Cercek A, Kemeny N, Abou-Alfa G, Iacobuzio-Donahue C, Cowzer D, Schultz N, Walch H, Balachandran V, Groot Koerkamp B, Kingham P, Soares K, Wei A, D'Angelica M, Drebin J, Chandwani R, Harding JJ, Jarnagin W
Clin Cancer Res 2024 Aug 15;30(16):3499-3511. doi: 10.1158/1078-0432.CCR-24-0657. PMID: 38864854Free PMC Article
Luschka Ducts of the Gallbladder in Adults: Case Series Report and Review of the Medical Literature.
Handra-Luca A, Ben Romdhane HM, Hong SM
Int J Surg Pathol 2020 Aug;28(5):482-489. Epub 2020 Jan 26 doi: 10.1177/1066896920901334. PMID: 31983263
Covered and uncovered biliary metal stents provide similar relief of biliary obstruction during neoadjuvant therapy in pancreatic cancer: a randomized trial.
Seo DW, Sherman S, Dua KS, Slivka A, Roy A, Costamagna G, Deviere J, Peetermans J, Rousseau M, Nakai Y, Isayama H, Kozarek R; Biliary SEMS During Neoadjuvant Therapy Study Group
Gastrointest Endosc 2019 Oct;90(4):602-612.e4. Epub 2019 Jul 2 doi: 10.1016/j.gie.2019.06.032. PMID: 31276674
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
J Hepatol 2018 May;68(5):959-969. Epub 2018 Jan 31 doi: 10.1016/j.jhep.2018.01.009. PMID: 29360550
Histological features of precancerous and early cancerous lesions of biliary tract carcinoma.
Aishima S, Kubo Y, Tanaka Y, Oda Y
J Hepatobiliary Pancreat Sci 2014 Jul;21(7):448-52. Epub 2014 Jan 21 doi: 10.1002/jhbp.71. PMID: 24446428

Recent systematic reviews

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract.
Roos E, Soer EC, Klompmaker S, Meijer LL, Besselink MG, Giovannetti E, Heger M, Kazemier G, Klümpen HJ, Takkenberg RB, Wilmink H, Würdinger T, Dijk F, van Gulik TM, Verheij J, van de Vijver MJ
Crit Rev Oncol Hematol 2019 Aug;140:8-16. Epub 2019 May 24 doi: 10.1016/j.critrevonc.2019.05.011. PMID: 31158800
A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice.
Xu X, Li J, Wu J, Zhu R, Ji W
Cardiovasc Intervent Radiol 2018 Feb;41(2):206-217. Epub 2017 Oct 26 doi: 10.1007/s00270-017-1827-6. PMID: 29075881

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