U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Extrahepatic Bile Duct Biliary Intraepithelial Neoplasia

MedGen UID:
474763
•Concept ID:
C3273130
•
Neoplastic Process
Synonyms: Extrahepatic Bile Duct BilIN; Extrahepatic Bile Duct Dysplasia

Definition

A neoplastic, non-invasive lesion that affects the extrahepatic bile duct epithelium. It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Biliary Intraepithelial Neoplasia

Professional guidelines

PubMed

A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage.
Nakanuma Y, Jang KT, Fukushima N, Furukawa T, Hong SM, Kim H, Lee KB, Zen Y, Jang JY, Kubota K
J Hepatobiliary Pancreat Sci 2018 Mar;25(3):181-187. Epub 2018 Feb 12 doi: 10.1002/jhbp.532. PMID: 29272078
Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria.
Zen Y, Adsay NV, Bardadin K, Colombari R, Ferrell L, Haga H, Hong SM, Hytiroglou P, Klöppel G, Lauwers GY, van Leeuwen DJ, Notohara K, Oshima K, Quaglia A, Sasaki M, Sessa F, Suriawinata A, Tsui W, Atomi Y, Nakanuma Y
Mod Pathol 2007 Jun;20(6):701-9. Epub 2007 Apr 13 doi: 10.1038/modpathol.3800788. PMID: 17431410
Cholangiocarcinoma: the impact of tumor location and treatment strategy on outcome.
Heron DE, Stein DE, Eschelman DJ, Topham AK, Waterman FM, Rosato EL, Alden M, Anne PR
Am J Clin Oncol 2003 Aug;26(4):422-8. doi: 10.1097/01.COC.0000026833.73428.1F. PMID: 12902899

Recent clinical studies

Etiology

Endoscopic papillectomy could be rewarding to patients with early stage duodenal ampullary carcinoma?
Suzuki K, Kurita Y, Kubota K, Fujita Y, Tsujino S, Koyama Y, Tsujikawa S, Tamura S, Yagi S, Hasegawa S, Sato T, Hosono K, Kobayashi N, Iwashita H, Yamanaka S, Fujii S, Endo I, Nakajima A
J Hepatobiliary Pancreat Sci 2024 Mar;31(3):203-212. Epub 2023 Nov 28 doi: 10.1002/jhbp.1398. PMID: 38014632
Prevalence and Clinical Significance of Biliary Intraepithelial Neoplasia (BilIN) in Cholangiocarcinoma.
Yoon KC, Yu YD, Kang WH, Jo HS, Kim DS, Kim JY
Am Surg 2019 May 1;85(5):511-517. PMID: 31126365
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma.
Kim HJ, Kim JS, Kim BH, Bak YT
Dig Surg 2018;35(2):116-120. Epub 2017 May 11 doi: 10.1159/000475848. PMID: 28490009
Treatment options for villous adenoma of the ampulla of Vater.
Hoyuela C, Cugat E, Veloso E, Marco C
HPB Surg 2000;11(5):325-30; discussion 330-1. doi: 10.1155/2000/86476. PMID: 10674748Free PMC Article

Diagnosis

Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage.
Nakanuma Y, Jang KT, Fukushima N, Furukawa T, Hong SM, Kim H, Lee KB, Zen Y, Jang JY, Kubota K
J Hepatobiliary Pancreat Sci 2018 Mar;25(3):181-187. Epub 2018 Feb 12 doi: 10.1002/jhbp.532. PMID: 29272078
Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater.
Jang KT, Ahn S
Arch Pathol Lab Med 2016 May;140(5):429-36. doi: 10.5858/arpa.2015-0319-RA. PMID: 27128300
Treatment options for villous adenoma of the ampulla of Vater.
Hoyuela C, Cugat E, Veloso E, Marco C
HPB Surg 2000;11(5):325-30; discussion 330-1. doi: 10.1155/2000/86476. PMID: 10674748Free PMC Article
Carcinoma of the gallbladder and extrahepatic biliary tree.
Johnson FW, Gilsdorf RB
Am Surg 1974 Aug;40(8):456-61. PMID: 4367274

Therapy

Pemetrexed and Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer Who Failed Gemcitabine-containing Chemotherapy: A Phase II Single-arm Prospective Study.
Lim SH, Hong JY, Park JO, Park YS, Kim ST
Anticancer Res 2023 Sep;43(9):4161-4167. doi: 10.21873/anticanres.16607. PMID: 37648323
Does high-grade dysplasia/carcinoma in situ of the biliary duct margin affect the prognosis of extrahepatic cholangiocarcinoma? A meta-analysis.
Ke Q, Wang B, Lin N, Wang L, Liu J
World J Surg Oncol 2019 Dec 9;17(1):211. doi: 10.1186/s12957-019-1749-7. PMID: 31818290Free PMC Article
The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma.
Sato Y, Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y, Kubo S
Pathol Int 2017 Mar;67(3):163-170. Epub 2017 Jan 31 doi: 10.1111/pin.12511. PMID: 28139862
Clinicopathological analysis and prognosis of extrahepatic bile duct cancer with a microscopic positive ductal margin.
Han IW, Jang JY, Lee KB, Kang MJ, Kwon W, Park JW, Chang YR, Kim SW
HPB (Oxford) 2014 Jun;16(6):575-81. Epub 2013 Dec 6 doi: 10.1111/hpb.12193. PMID: 24308425Free PMC Article
Epidermal growth factor receptor immunoreactivity in gallbladder and extrahepatic biliary tract tumours.
Lee CS, Pirdas A
Pathol Res Pract 1995 Nov;191(11):1087-91. doi: 10.1016/S0344-0338(11)80652-7. PMID: 8822109

Prognosis

Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H
J Pathol 2023 Aug;260(4):478-492. Epub 2023 Jun 13 doi: 10.1002/path.6139. PMID: 37310065
Prevalence and Clinical Significance of Biliary Intraepithelial Neoplasia (BilIN) in Cholangiocarcinoma.
Yoon KC, Yu YD, Kang WH, Jo HS, Kim DS, Kim JY
Am Surg 2019 May 1;85(5):511-517. PMID: 31126365
Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma.
Kim HJ, Kim JS, Kim BH, Bak YT
Dig Surg 2018;35(2):116-120. Epub 2017 May 11 doi: 10.1159/000475848. PMID: 28490009
Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246
Treatment options for villous adenoma of the ampulla of Vater.
Hoyuela C, Cugat E, Veloso E, Marco C
HPB Surg 2000;11(5):325-30; discussion 330-1. doi: 10.1155/2000/86476. PMID: 10674748Free PMC Article

Clinical prediction guides

Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H
J Pathol 2023 Aug;260(4):478-492. Epub 2023 Jun 13 doi: 10.1002/path.6139. PMID: 37310065
Clinicopathological Features and Long-Term Outcomes of Intraductal Papillary Neoplasms of the Bile Duct of the Liver: Single-Institution Experience with 146 Patients.
Youn JM, Hwang S, Ahn CS, Moon DB, Ha TY, Song GW, Jung DH, Hong SM
J Gastrointest Surg 2022 Jul;26(7):1394-1405. Epub 2022 Feb 9 doi: 10.1007/s11605-022-05268-2. PMID: 35141839
miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR-451a/ATF2 axis.
Loeffler MA, Hu J, Kirchner M, Wei X, Xiao Y, Albrecht T, De La Torre C, Sticht C, Banales JM, Vogel MN, Pathil-Warth A, Mehrabi A, Hoffmann K, Rupp C, Köhler B, Springfeld C, Schirmacher P, Ji J, Roessler S, Goeppert B
J Pathol 2020 Nov;252(3):239-251. Epub 2020 Sep 15 doi: 10.1002/path.5514. PMID: 32710569
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...