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Extrahepatic Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

MedGen UID:
474768
•Concept ID:
C3273135
•
Neoplastic Process
Synonyms: Extrahepatic Bile Duct IPN with an Associated Invasive Carcinoma; Extrahepatic Bile Duct Papillary Neoplasm with an Associated Invasive Carcinoma

Definition

A papillary neoplasm that arises from the epithelium of the extrahepatic bile ducts and it is associated with an invasive carcinomatous component. The carcinomatous component is an adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

Professional guidelines

PubMed

Proposed indications for limited resection of early ampulla of Vater carcinoma: clinico-histopathological criteria to confirm cure.
Aiura K, Hibi T, Fujisaki H, Kitago M, Tanabe M, Kawachi S, Itano O, Shinoda M, Yagi H, Masugi Y, Sakamoto M, Kitagawa Y
J Hepatobiliary Pancreat Sci 2012 Nov;19(6):707-16. doi: 10.1007/s00534-011-0492-4. PMID: 22203456Free PMC Article

Recent clinical studies

Etiology

Intraductal papillary neoplasm of the bile duct: diagnostic value of MRI features in differentiating pathologic subclassifications-type 1 versus type 2.
Jeon SK, Lee JM, Yoo J, Park S, Joo I, Yoon JH, Lee KB
Eur Radiol 2024 Jul;34(7):4674-4685. Epub 2023 Dec 19 doi: 10.1007/s00330-023-10491-9. PMID: 38114846
Is a specific T classification needed for extrahepatic intraductal papillary neoplasm of the bile duct (IPNB) type 2 associated with invasive carcinoma?
Mitake Y, Onoe S, Igami T, Mizuno T, Yamaguchi J, Sunagawa M, Watanabe N, Kawakatsu S, Shimoyama Y, Ebata T
J Hepatobiliary Pancreat Sci 2023 Jun;30(6):745-754. Epub 2022 Nov 21 doi: 10.1002/jhbp.1269. PMID: 36349508
Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder.
Bennett S, Marginean EC, Paquin-Gobeil M, Wasserman J, Weaver J, Mimeault R, Balaa FK, Martel G
HPB (Oxford) 2015 Sep;17(9):811-8. doi: 10.1111/hpb.12460. PMID: 26278323Free PMC Article

Diagnosis

Intraductal papillary neoplasm of the bile duct: diagnostic value of MRI features in differentiating pathologic subclassifications-type 1 versus type 2.
Jeon SK, Lee JM, Yoo J, Park S, Joo I, Yoon JH, Lee KB
Eur Radiol 2024 Jul;34(7):4674-4685. Epub 2023 Dec 19 doi: 10.1007/s00330-023-10491-9. PMID: 38114846
Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
The CT fish mouth ampulla sign: a highly specific finding in main duct and mixed intraductal papillary mucinous neoplasms.
Zhang TT, Sadler TJ, Whitley S, Brais R, Godfrey E
Br J Radiol 2019 Nov;92(1103):20190461. Epub 2019 Aug 28 doi: 10.1259/bjr.20190461. PMID: 31430199Free PMC Article
The clinicopathological features of intraductal papillary neoplasms of the bile duct in a Chinese population.
Yang J, Wang W, Yan L
Dig Liver Dis 2012 Mar;44(3):251-6. Epub 2011 Sep 17 doi: 10.1016/j.dld.2011.08.014. PMID: 21930444

Prognosis

Prognostic Significance of Intratumoral and Peritumoral Budding in Distal Extrahepatic Bile Duct Carcinoma.
Jun SY, Hong SM, An S
Pathobiology 2024;91(4):254-267. Epub 2023 Dec 19 doi: 10.1159/000535847. PMID: 38113866Free PMC Article
Is a specific T classification needed for extrahepatic intraductal papillary neoplasm of the bile duct (IPNB) type 2 associated with invasive carcinoma?
Mitake Y, Onoe S, Igami T, Mizuno T, Yamaguchi J, Sunagawa M, Watanabe N, Kawakatsu S, Shimoyama Y, Ebata T
J Hepatobiliary Pancreat Sci 2023 Jun;30(6):745-754. Epub 2022 Nov 21 doi: 10.1002/jhbp.1269. PMID: 36349508
Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder.
Bennett S, Marginean EC, Paquin-Gobeil M, Wasserman J, Weaver J, Mimeault R, Balaa FK, Martel G
HPB (Oxford) 2015 Sep;17(9):811-8. doi: 10.1111/hpb.12460. PMID: 26278323Free PMC Article
Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.
Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V
Mod Pathol 2015 Sep;28(9):1249-64. Epub 2015 Jun 26 doi: 10.1038/modpathol.2015.61. PMID: 26111977

Clinical prediction guides

Prognostic Significance of Intratumoral and Peritumoral Budding in Distal Extrahepatic Bile Duct Carcinoma.
Jun SY, Hong SM, An S
Pathobiology 2024;91(4):254-267. Epub 2023 Dec 19 doi: 10.1159/000535847. PMID: 38113866Free PMC Article
Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.
Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V
Mod Pathol 2015 Sep;28(9):1249-64. Epub 2015 Jun 26 doi: 10.1038/modpathol.2015.61. PMID: 26111977
Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma.
Shinozaki A, Shibahara J, Noda N, Tanaka M, Aoki T, Kokudo N, Fukayama M
Virchows Arch 2011 Jul;459(1):73-80. Epub 2011 May 24 doi: 10.1007/s00428-011-1092-z. PMID: 21607649
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286

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