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Primary Valvular Disorder

MedGen UID:
476427
Concept ID:
C3274794
Disease or Syndrome

Definition

Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Valvular Disorder

Professional guidelines

PubMed

Arvanitaki A, Giannakoulas G, Baumgartner H, Lammers AE
Heart 2020 Nov;106(21):1638-1645. Epub 2020 Jul 20 doi: 10.1136/heartjnl-2020-316665. PMID: 32690623
Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, Kociol RD, Lewis EF, Mehra MR, Pagani FD, Raval AN, Ward C; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Cardiovascular Surgery and Anesthesia
Circulation 2018 May 15;137(20):e578-e622. Epub 2018 Apr 12 doi: 10.1161/CIR.0000000000000560. PMID: 29650544
Dijkema EJ, Leiner T, Grotenhuis HB
Heart 2017 Aug;103(15):1148-1155. Epub 2017 Apr 4 doi: 10.1136/heartjnl-2017-311173. PMID: 28377475

Recent clinical studies

Etiology

Holmes DR Jr, Korsholm K, Rodés-Cabau J, Saw J, Berti S, Alkhouli MA
EuroIntervention 2023 Feb 6;18(13):e1038-e1065. doi: 10.4244/EIJ-D-22-00627. PMID: 36760206Free PMC Article
Arvanitaki A, Giannakoulas G, Baumgartner H, Lammers AE
Heart 2020 Nov;106(21):1638-1645. Epub 2020 Jul 20 doi: 10.1136/heartjnl-2020-316665. PMID: 32690623
Iung B, Delgado V, Rosenhek R, Price S, Prendergast B, Wendler O, De Bonis M, Tribouilloy C, Evangelista A, Bogachev-Prokophiev A, Apor A, Ince H, Laroche C, Popescu BA, Piérard L, Haude M, Hindricks G, Ruschitzka F, Windecker S, Bax JJ, Maggioni A, Vahanian A; EORP VHD II Investigators
Circulation 2019 Oct;140(14):1156-1169. Epub 2019 Sep 12 doi: 10.1161/CIRCULATIONAHA.119.041080. PMID: 31510787
Lala A, Desai AS
Heart Fail Clin 2014 Apr;10(2):353-65. doi: 10.1016/j.hfc.2013.10.002. PMID: 24656111
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Diagnosis

Kisling A, Gallagher R
Prim Care 2024 Mar;51(1):95-109. Epub 2023 Sep 7 doi: 10.1016/j.pop.2023.08.003. PMID: 38278576
Fortea JI, Puente Á, Cuadrado A, Huelin P, Pellón R, González Sánchez FJ, Mayorga M, Cagigal ML, García Carrera I, Cobreros M, Crespo J, Fábrega E
Int J Mol Sci 2020 Dec 10;21(24) doi: 10.3390/ijms21249420. PMID: 33321947Free PMC Article
Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, Kociol RD, Lewis EF, Mehra MR, Pagani FD, Raval AN, Ward C; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Cardiovascular Surgery and Anesthesia
Circulation 2018 May 15;137(20):e578-e622. Epub 2018 Apr 12 doi: 10.1161/CIR.0000000000000560. PMID: 29650544
Mrsic Z, Hopkins SP, Antevil JL, Mullenix PS
Prim Care 2018 Mar;45(1):81-94. Epub 2017 Dec 27 doi: 10.1016/j.pop.2017.10.002. PMID: 29406946
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Therapy

Holmes DR Jr, Korsholm K, Rodés-Cabau J, Saw J, Berti S, Alkhouli MA
EuroIntervention 2023 Feb 6;18(13):e1038-e1065. doi: 10.4244/EIJ-D-22-00627. PMID: 36760206Free PMC Article
Dawwas GK, Cuker A, Barnes GD, Lewis JD, Hennessy S
Ann Intern Med 2022 Nov;175(11):1506-1514. Epub 2022 Oct 18 doi: 10.7326/M22-0318. PMID: 36252244Free PMC Article
Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A
JAMA Neurol 2022 Jun 1;79(6):554-564. doi: 10.1001/jamaneurol.2022.0829. PMID: 35499850Free PMC Article
Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, Kociol RD, Lewis EF, Mehra MR, Pagani FD, Raval AN, Ward C; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Cardiovascular Surgery and Anesthesia
Circulation 2018 May 15;137(20):e578-e622. Epub 2018 Apr 12 doi: 10.1161/CIR.0000000000000560. PMID: 29650544
El Sabbagh A, Reddy YNV, Nishimura RA
JACC Cardiovasc Imaging 2018 Apr;11(4):628-643. doi: 10.1016/j.jcmg.2018.01.009. PMID: 29622181

Prognosis

Fortea JI, Puente Á, Cuadrado A, Huelin P, Pellón R, González Sánchez FJ, Mayorga M, Cagigal ML, García Carrera I, Cobreros M, Crespo J, Fábrega E
Int J Mol Sci 2020 Dec 10;21(24) doi: 10.3390/ijms21249420. PMID: 33321947Free PMC Article
Arvanitaki A, Giannakoulas G, Baumgartner H, Lammers AE
Heart 2020 Nov;106(21):1638-1645. Epub 2020 Jul 20 doi: 10.1136/heartjnl-2020-316665. PMID: 32690623
Larsson SC, Bäck M, Rees JMB, Mason AM, Burgess S
Eur Heart J 2020 Jan 7;41(2):221-226. doi: 10.1093/eurheartj/ehz388. PMID: 31195408Free PMC Article
Lala A, Desai AS
Heart Fail Clin 2014 Apr;10(2):353-65. doi: 10.1016/j.hfc.2013.10.002. PMID: 24656111
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Clinical prediction guides

Dawwas GK, Cuker A, Barnes GD, Lewis JD, Hennessy S
Ann Intern Med 2022 Nov;175(11):1506-1514. Epub 2022 Oct 18 doi: 10.7326/M22-0318. PMID: 36252244Free PMC Article
Arvanitaki A, Giannakoulas G, Baumgartner H, Lammers AE
Heart 2020 Nov;106(21):1638-1645. Epub 2020 Jul 20 doi: 10.1136/heartjnl-2020-316665. PMID: 32690623
Wilson DP, Jacobson TA, Jones PH, Koschinsky ML, McNeal CJ, Nordestgaard BG, Orringer CE
J Clin Lipidol 2019 May-Jun;13(3):374-392. Epub 2019 May 17 doi: 10.1016/j.jacl.2019.04.010. PMID: 31147269
El Sabbagh A, Reddy YNV, Nishimura RA
JACC Cardiovasc Imaging 2018 Apr;11(4):628-643. doi: 10.1016/j.jcmg.2018.01.009. PMID: 29622181
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Recent systematic reviews

Tabrizi NS, Demos RA, Schumann R, Musuku SR, Shapeton AD
J Cardiothorac Vasc Anesth 2024 Feb;38(2):505-516. Epub 2023 Sep 24 doi: 10.1053/j.jvca.2023.09.027. PMID: 37880038
Kuno T, Watanabe A, Shoji S, Fujisaki T, Ueyama H, Takagi H, Deharo P, Cuisset T, Bangalore S, Mehran R, Stone GW, Kohsaka S, Bhatt DL
Circ Cardiovasc Interv 2023 Sep;16(9):e013242. Epub 2023 Aug 23 doi: 10.1161/CIRCINTERVENTIONS.123.013242. PMID: 37609850
Mead GE, Sposato LA, Sampaio Silva G, Yperzeele L, Wu S, Kutlubaev M, Cheyne J, Wahab K, Urrutia VC, Sharma VK, Sylaja PN, Hill K, Steiner T, Liebeskind DS, Rabinstein AA
Int J Stroke 2023 Jun;18(5):499-531. Epub 2023 Mar 1 doi: 10.1177/17474930231156753. PMID: 36725717Free PMC Article
Goel RR, Hardy SC, Brown T
Cochrane Database Syst Rev 2021 Sep 30;9(9):CD001097. doi: 10.1002/14651858.CD001097.pub4. PMID: 34591328Free PMC Article
Barnes H, Brown Z, Burns A, Williams T
Cochrane Database Syst Rev 2019 Jan 31;1(1):CD012621. doi: 10.1002/14651858.CD012621.pub2. PMID: 30701543Free PMC Article

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