U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Allergic bronchopulmonary aspergillosis

MedGen UID:
479932
Concept ID:
C3278302
Disease or Syndrome
Synonym: ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS, FAMILIAL
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015243
OMIM®: 103920
Orphanet: ORPHA1164

Definition

A rare immunologic pulmonary disorder caused by hypersensitivity to <i>Aspergillus fumigatus</i>, clinically manifesting with poorly controlled asthma and recurrent pulmonary infiltrates. [from ORDO]

Clinical features

From HPO
Abnormality of the immune system
MedGen UID:
867388
Concept ID:
C4021753
Pathologic Function
An abnormality of the immune system.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergic bronchopulmonary aspergillosis

Professional guidelines

PubMed

Agarwal R, Sehgal IS, Muthu V, Denning DW, Chakrabarti A, Soundappan K, Garg M, Rudramurthy SM, Dhooria S, Armstrong-James D, Asano K, Gangneux JP, Chotirmall SH, Salzer HJF, Chalmers JD, Godet C, Joest M, Page I, Nair P, Arjun P, Dhar R, Jat KR, Joe G, Krishnaswamy UM, Mathew JL, Maturu VN, Mohan A, Nath A, Patel D, Savio J, Saxena P, Soman R, Thangakunam B, Baxter CG, Bongomin F, Calhoun WJ, Cornely OA, Douglass JA, Kosmidis C, Meis JF, Moss R, Pasqualotto AC, Seidel D, Sprute R, Prasad KT, Aggarwal AN
Eur Respir J 2024 Apr;63(4) Epub 2024 Apr 4 doi: 10.1183/13993003.00061-2024. PMID: 38423624Free PMC Article
Agarwal R, Muthu V, Sehgal IS
Semin Respir Crit Care Med 2024 Feb;45(1):114-127. Epub 2023 Dec 28 doi: 10.1055/s-0043-1776912. PMID: 38154470
Echeverria-Esnal D, Martín-Ontiyuelo C, Navarrete-Rouco ME, Barcelo-Vidal J, Conde-Estévez D, Carballo N, De-Antonio Cuscó M, Ferrández O, Horcajada JP, Grau S
Expert Rev Anti Infect Ther 2022 Feb;20(2):179-197. Epub 2021 Aug 18 doi: 10.1080/14787210.2021.1962292. PMID: 34328373

Recent clinical studies

Etiology

Agarwal R, Sehgal IS, Muthu V, Denning DW, Chakrabarti A, Soundappan K, Garg M, Rudramurthy SM, Dhooria S, Armstrong-James D, Asano K, Gangneux JP, Chotirmall SH, Salzer HJF, Chalmers JD, Godet C, Joest M, Page I, Nair P, Arjun P, Dhar R, Jat KR, Joe G, Krishnaswamy UM, Mathew JL, Maturu VN, Mohan A, Nath A, Patel D, Savio J, Saxena P, Soman R, Thangakunam B, Baxter CG, Bongomin F, Calhoun WJ, Cornely OA, Douglass JA, Kosmidis C, Meis JF, Moss R, Pasqualotto AC, Seidel D, Sprute R, Prasad KT, Aggarwal AN
Eur Respir J 2024 Apr;63(4) Epub 2024 Apr 4 doi: 10.1183/13993003.00061-2024. PMID: 38423624Free PMC Article
Roboubi A, Audousset C, Fréalle É, Brun AL, Laurent F, Vitte J, Mortuaire G, Lefevre G, Cadranel J, Chenivesse C
J Mycol Med 2023 Aug;33(3):101392. Epub 2023 May 4 doi: 10.1016/j.mycmed.2023.101392. PMID: 37172543
Agarwal R, Sehgal IS, Dhooria S, Muthu V, Prasad KT, Bal A, Aggarwal AN, Chakrabarti A
Indian J Med Res 2020 Jun;151(6):529-549. doi: 10.4103/ijmr.IJMR_1187_19. PMID: 32719226Free PMC Article
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, Ullmann AJ, Dimopoulos G, Lange C; European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Eur Respir J 2016 Jan;47(1):45-68. doi: 10.1183/13993003.00583-2015. PMID: 26699723

Diagnosis

Agarwal R, Muthu V, Sehgal IS
Semin Respir Crit Care Med 2024 Feb;45(1):114-127. Epub 2023 Dec 28 doi: 10.1055/s-0043-1776912. PMID: 38154470
Agarwal R, Muthu V, Sehgal IS, Dhooria S, Prasad KT, Aggarwal AN
Clin Chest Med 2022 Mar;43(1):99-125. doi: 10.1016/j.ccm.2021.12.002. PMID: 35236565
Asano K, Hebisawa A, Ishiguro T, Takayanagi N, Nakamura Y, Suzuki J, Okada N, Tanaka J, Fukutomi Y, Ueki S, Fukunaga K, Konno S, Matsuse H, Kamei K, Taniguchi M, Shimoda T, Oguma T; Japan ABPM Research Program
J Allergy Clin Immunol 2021 Apr;147(4):1261-1268.e5. Epub 2020 Sep 10 doi: 10.1016/j.jaci.2020.08.029. PMID: 32920094
Agarwal R, Sehgal IS, Dhooria S, Muthu V, Prasad KT, Bal A, Aggarwal AN, Chakrabarti A
Indian J Med Res 2020 Jun;151(6):529-549. doi: 10.4103/ijmr.IJMR_1187_19. PMID: 32719226Free PMC Article
Agarwal R, Chakrabarti A, Shah A, Gupta D, Meis JF, Guleria R, Moss R, Denning DW; ABPA complicating asthma ISHAM working group
Clin Exp Allergy 2013 Aug;43(8):850-73. doi: 10.1111/cea.12141. PMID: 23889240

Therapy

Agarwal R, Sehgal IS, Muthu V, Denning DW, Chakrabarti A, Soundappan K, Garg M, Rudramurthy SM, Dhooria S, Armstrong-James D, Asano K, Gangneux JP, Chotirmall SH, Salzer HJF, Chalmers JD, Godet C, Joest M, Page I, Nair P, Arjun P, Dhar R, Jat KR, Joe G, Krishnaswamy UM, Mathew JL, Maturu VN, Mohan A, Nath A, Patel D, Savio J, Saxena P, Soman R, Thangakunam B, Baxter CG, Bongomin F, Calhoun WJ, Cornely OA, Douglass JA, Kosmidis C, Meis JF, Moss R, Pasqualotto AC, Seidel D, Sprute R, Prasad KT, Aggarwal AN
Eur Respir J 2024 Apr;63(4) Epub 2024 Apr 4 doi: 10.1183/13993003.00061-2024. PMID: 38423624Free PMC Article
Barbosa M, Chalmers JD
Presse Med 2023 Sep;52(3):104174. Epub 2023 Sep 30 doi: 10.1016/j.lpm.2023.104174. PMID: 37778637
Roboubi A, Audousset C, Fréalle É, Brun AL, Laurent F, Vitte J, Mortuaire G, Lefevre G, Cadranel J, Chenivesse C
J Mycol Med 2023 Aug;33(3):101392. Epub 2023 May 4 doi: 10.1016/j.mycmed.2023.101392. PMID: 37172543
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957

Prognosis

Barbosa M, Chalmers JD
Presse Med 2023 Sep;52(3):104174. Epub 2023 Sep 30 doi: 10.1016/j.lpm.2023.104174. PMID: 37778637
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Agarwal R, Muthu V, Sehgal IS, Dhooria S, Prasad KT, Aggarwal AN
Clin Chest Med 2022 Mar;43(1):99-125. doi: 10.1016/j.ccm.2021.12.002. PMID: 35236565
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Greenberger PA, Bush RK, Demain JG, Luong A, Slavin RG, Knutsen AP
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):703-8. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.08.007. PMID: 25439360Free PMC Article

Clinical prediction guides

Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Kosmidis C, Denning DW
Thorax 2015 Mar;70(3):270-7. Epub 2014 Oct 29 doi: 10.1136/thoraxjnl-2014-206291. PMID: 25354514
Greenberger PA, Bush RK, Demain JG, Luong A, Slavin RG, Knutsen AP
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):703-8. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.08.007. PMID: 25439360Free PMC Article
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article
Latgé JP
Clin Microbiol Rev 1999 Apr;12(2):310-50. doi: 10.1128/CMR.12.2.310. PMID: 10194462Free PMC Article

Recent systematic reviews

Chen X, Zhi H, Wang X, Zhou Z, Luo H, Li J, Sehmi R, O'Byrne PM, Chen R
Lung 2024 Aug;202(4):367-383. Epub 2024 Jun 19 doi: 10.1007/s00408-024-00717-y. PMID: 38898129
Jin M, Douglass JA, Elborn JS, Agarwal R, Calhoun WJ, Lazarewicz S, Jaumont X, Yan M
J Allergy Clin Immunol Pract 2023 Mar;11(3):896-905. Epub 2022 Dec 26 doi: 10.1016/j.jaip.2022.12.012. PMID: 36581073
Francis NZ, Southern KW
Cochrane Database Syst Rev 2022 Sep 2;9(9):CD002204. doi: 10.1002/14651858.CD002204.pub5. PMID: 36053129Free PMC Article
Jat KR, Walia DK, Khairwa A
Cochrane Database Syst Rev 2021 Sep 22;9(9):CD010288. doi: 10.1002/14651858.CD010288.pub5. PMID: 34550603Free PMC Article
Jat KR, Walia DK, Khairwa A
Cochrane Database Syst Rev 2018 Mar 18;3(3):CD010288. doi: 10.1002/14651858.CD010288.pub4. PMID: 29551015Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...