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Peripheral vitreoretinal degeneration

MedGen UID:
481979
•Concept ID:
C3280349
•
Finding
HPO: HP:0200071

Definition

A type of vitreoretinal degeneration with manifestations that are concentrated at the periphery of the retina. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral vitreoretinal degeneration

Conditions with this feature

Myopia, high, with cataract and vitreoretinal degeneration
MedGen UID:
481976
•Concept ID:
C3280346
•
Disease or Syndrome
See: Condition Record
Myopia, high, with cataract and vitreoretinal degeneration

Professional guidelines

PubMed

Recommendations for management of peripheral retinal degenerations.
Venkatesh R, Sharief S, Thadani A, Ratra D, Mohan S, Narayanan R, Narula R, Asad Y, Roy R, Jayadev C, Yadav NK
Indian J Ophthalmol 2022 Oct;70(10):3681-3686. doi: 10.4103/ijo.IJO_689_22. PMID: 36190072Free PMC Article

Recent clinical studies

Etiology

Longitudinal Observation of Two Giant Peripheral Atrophic Retinal Holes Left Untreated.
Lucente A, Taloni A, Scorcia V, Giannaccare G
Ophthalmic Surg Lasers Imaging Retina 2024 Mar;55(3):176-178. Epub 2024 Jan 19 doi: 10.3928/23258160-20240105-01. PMID: 38270565
Visualisation of peripheral retinal degenerations and anomalies with ocular imaging.
Cheung R, Ly A, Katalinic P, Coroneo MT, Chang A, Kalloniatis M, Madigan MC, Nivison-Smith L
Semin Ophthalmol 2022 Jul 4;37(5):554-582. Epub 2022 Mar 7 doi: 10.1080/08820538.2022.2039222. PMID: 35254953
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies.
Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R
Lancet 2015 Feb 7;385(9967):509-16. Epub 2014 Oct 15 doi: 10.1016/S0140-6736(14)61376-3. PMID: 25458728
Pars plana vitrectomy compared with pars plana vitrectomy combined with scleral buckle in the primary management of noncomplex rhegmatogenous retinal detachment.
Orlin A, Hewing NJ, Nissen M, Lee S, Kiss S, DʼAmico DJ, Chan RV
Retina 2014 Jun;34(6):1069-75. doi: 10.1097/IAE.0000000000000050. PMID: 24853687
Exudative retinal detachment in X-linked retinoschisis.
Fong DS, Frederick AR Jr, Blumenkranz MS, Walton DS
Ophthalmic Surg Lasers 1998 Apr;29(4):332-5. PMID: 9571668

Diagnosis

Longitudinal Observation of Two Giant Peripheral Atrophic Retinal Holes Left Untreated.
Lucente A, Taloni A, Scorcia V, Giannaccare G
Ophthalmic Surg Lasers Imaging Retina 2024 Mar;55(3):176-178. Epub 2024 Jan 19 doi: 10.3928/23258160-20240105-01. PMID: 38270565
Multimodal Retinal Imaging Findings in Two Cousins With VCAN-Related Vitreoretinopathy or Wagner Disease.
Parra MM, Spoth E, Ronquillo CC, Henderson R, Hartnett ME
Ophthalmic Surg Lasers Imaging Retina 2022 Nov;53(11):639-643. Epub 2022 Nov 1 doi: 10.3928/23258160-20221026-01. PMID: 36378611
Recommendations for management of peripheral retinal degenerations.
Venkatesh R, Sharief S, Thadani A, Ratra D, Mohan S, Narayanan R, Narula R, Asad Y, Roy R, Jayadev C, Yadav NK
Indian J Ophthalmol 2022 Oct;70(10):3681-3686. doi: 10.4103/ijo.IJO_689_22. PMID: 36190072Free PMC Article
High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2.
Mordechai S, Gradstein L, Pasanen A, Ofir R, El Amour K, Levy J, Belfair N, Lifshitz T, Joshua S, Narkis G, Elbedour K, Myllyharju J, Birk OS
Am J Hum Genet 2011 Sep 9;89(3):438-45. Epub 2011 Sep 1 doi: 10.1016/j.ajhg.2011.08.003. PMID: 21885030Free PMC Article
Exudative retinal detachment in X-linked retinoschisis.
Fong DS, Frederick AR Jr, Blumenkranz MS, Walton DS
Ophthalmic Surg Lasers 1998 Apr;29(4):332-5. PMID: 9571668

Therapy

Rhegmatogenous retinal detachment following intravitreal ocriplasmin.
Madi HA, Haynes RJ, Depla D, de la Cour MD, Lesnik-Oberstein S, Muqit MM, Patton N, Price N, Steel DH
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2333-2338. Epub 2016 Jun 8 doi: 10.1007/s00417-016-3398-7. PMID: 27278373Free PMC Article
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies.
Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R
Lancet 2015 Feb 7;385(9967):509-16. Epub 2014 Oct 15 doi: 10.1016/S0140-6736(14)61376-3. PMID: 25458728
Photodynamic therapy with verteporfin for polypoidal choroidal vasculopathy.
Lee MW, Yeo I, Wong D, Ang CL
Eye (Lond) 2009 Jun;23(6):1417-22. Epub 2008 Aug 29 doi: 10.1038/eye.2008.265. PMID: 18756283
Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization.
Park CH, Toth CA
Am J Ophthalmol 2003 Nov;136(5):830-5. doi: 10.1016/s0002-9394(03)00723-2. PMID: 14597033
Lattice degeneration of the retina and retinal detachment.
Semes LP
Optom Clin 1992;2(3):71-91. PMID: 1463916

Prognosis

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies.
Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R
Lancet 2015 Feb 7;385(9967):509-16. Epub 2014 Oct 15 doi: 10.1016/S0140-6736(14)61376-3. PMID: 25458728
Pars plana vitrectomy compared with pars plana vitrectomy combined with scleral buckle in the primary management of noncomplex rhegmatogenous retinal detachment.
Orlin A, Hewing NJ, Nissen M, Lee S, Kiss S, DʼAmico DJ, Chan RV
Retina 2014 Jun;34(6):1069-75. doi: 10.1097/IAE.0000000000000050. PMID: 24853687
Photodynamic therapy with verteporfin for polypoidal choroidal vasculopathy.
Lee MW, Yeo I, Wong D, Ang CL
Eye (Lond) 2009 Jun;23(6):1417-22. Epub 2008 Aug 29 doi: 10.1038/eye.2008.265. PMID: 18756283
Clinical features of the congenital vitreoretinopathies.
Edwards AO
Eye (Lond) 2008 Oct;22(10):1233-42. Epub 2008 Feb 29 doi: 10.1038/eye.2008.38. PMID: 18309337
Exudative retinal detachment in X-linked retinoschisis.
Fong DS, Frederick AR Jr, Blumenkranz MS, Walton DS
Ophthalmic Surg Lasers 1998 Apr;29(4):332-5. PMID: 9571668

Clinical prediction guides

Longitudinal Observation of Two Giant Peripheral Atrophic Retinal Holes Left Untreated.
Lucente A, Taloni A, Scorcia V, Giannaccare G
Ophthalmic Surg Lasers Imaging Retina 2024 Mar;55(3):176-178. Epub 2024 Jan 19 doi: 10.3928/23258160-20240105-01. PMID: 38270565
Navigated single-capture 3D and cross-sectional wide-field OCT of the mid and peripheral retina and vitreoretinal interface.
Stanga PE, Pastor-Idoate S, Reinstein U, Vatas P, Patel U, Dubovy S, Reinstein DZ, Zahavi O
Eur J Ophthalmol 2022 May;32(3):1642-1651. Epub 2021 Jul 3 doi: 10.1177/11206721211026100. PMID: 34218694
High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2.
Mordechai S, Gradstein L, Pasanen A, Ofir R, El Amour K, Levy J, Belfair N, Lifshitz T, Joshua S, Narkis G, Elbedour K, Myllyharju J, Birk OS
Am J Hum Genet 2011 Sep 9;89(3):438-45. Epub 2011 Sep 1 doi: 10.1016/j.ajhg.2011.08.003. PMID: 21885030Free PMC Article
Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization.
Park CH, Toth CA
Am J Ophthalmol 2003 Nov;136(5):830-5. doi: 10.1016/s0002-9394(03)00723-2. PMID: 14597033
Retinal vascular pattern in familial exudative vitreoretinopathy.
Miyakubo H, Hashimoto K, Miyakubo S
Ophthalmology 1984 Dec;91(12):1524-30. doi: 10.1016/s0161-6420(84)34119-7. PMID: 6084219

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