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Atrophic rhinitis

MedGen UID:
48450
•Concept ID:
C0035459
•
Disease or Syndrome
Synonyms: Atrophic Rhinitides; Atrophic Rhinitis; Rhinitides, Atrophic; Rhinitis, Atrophic
SNOMED CT: Atrophic rhinitis (28111002)
 
Monarch Initiative: MONDO:0005659

Definition

A chronic inflammation in which the nasal mucosa gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony turbinates, and the foul-smelling mucus which forms a greenish crust (ozena). [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtrophic rhinitis

Professional guidelines

PubMed

Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617
Treatment of atrophic rhinitis.
Yadav YG, Seth RR
Ear Nose Throat J 1979 May;58(5):223-7. PMID: 456303
A nine years' review of 273 cases of atrophic rhinitis and its management.
Sinha SN, Sardana DS, Rajvanshi VS
J Laryngol Otol 1977 Jul;91(7):591-600. doi: 10.1017/s0022215100084097. PMID: 19546

Recent clinical studies

Etiology

Chronic Nonallergic Rhinitis.
Sur DKC, Plesa ML
Am Fam Physician 2018 Aug 1;98(3):171-176. PMID: 30215894
Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617
Interventions for atrophic rhinitis.
Mishra A, Kawatra R, Gola M
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD008280. doi: 10.1002/14651858.CD008280.pub2. PMID: 22336840Free PMC Article
Rhinitis sicca, dry nose and atrophic rhinitis: a review of the literature.
Hildenbrand T, Weber RK, Brehmer D
Eur Arch Otorhinolaryngol 2011 Jan;268(1):17-26. Epub 2010 Sep 29 doi: 10.1007/s00405-010-1391-z. PMID: 20878413
Tracheobronchopathia osteochondroplastica. Report of a young man with severe disease and retrospective review of 18 cases.
Vilkman S, Keistinen T
Respiration 1995;62(3):151-4. doi: 10.1159/000196411. PMID: 7569336

Diagnosis

Management of Postsurgical Empty Nose Syndrome.
Talmadge J, Nayak JV, Yao W, Citardi MJ
Facial Plast Surg Clin North Am 2019 Nov;27(4):465-475. doi: 10.1016/j.fsc.2019.07.005. PMID: 31587766
Atrophic Rhinitis.
Bakshi SS
J Allergy Clin Immunol Pract 2019 Nov-Dec;7(8):2850. Epub 2019 Aug 23 doi: 10.1016/j.jaip.2019.07.007. PMID: 31451401
Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617
Rhinitis.
Beard S
Prim Care 2014 Mar;41(1):33-46. Epub 2013 Nov 28 doi: 10.1016/j.pop.2013.10.005. PMID: 24439879Free PMC Article
Rhinitis medicamentosa.
Black MJ, Remsen KA
Can Med Assoc J 1980 Apr 19;122(8):881-4. PMID: 6154514Free PMC Article

Therapy

Management of Postsurgical Empty Nose Syndrome.
Talmadge J, Nayak JV, Yao W, Citardi MJ
Facial Plast Surg Clin North Am 2019 Nov;27(4):465-475. doi: 10.1016/j.fsc.2019.07.005. PMID: 31587766
Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617
Rhinitis.
Beard S
Prim Care 2014 Mar;41(1):33-46. Epub 2013 Nov 28 doi: 10.1016/j.pop.2013.10.005. PMID: 24439879Free PMC Article
Chronic rhinitis.
Simons FE
Pediatr Clin North Am 1984 Aug;31(4):801-19. doi: 10.1016/s0031-3955(16)34646-6. PMID: 6205358
Rhinitis medicamentosa.
Black MJ, Remsen KA
Can Med Assoc J 1980 Apr 19;122(8):881-4. PMID: 6154514Free PMC Article

Prognosis

Repair of nasal septal perforation using middle turbinate flap (monopedicled superiory based bone included conchal flap): a new unilateral middle turbinate mucosal flap technique.
Hanci D, Altun H
Eur Arch Otorhinolaryngol 2015 Jul;272(7):1707-12. Epub 2014 Sep 5 doi: 10.1007/s00405-014-3266-1. PMID: 25190253
Overview of the treatment of allergic rhinitis and nonallergic rhinopathy.
Greiner AN, Meltzer EO
Proc Am Thorac Soc 2011 Mar;8(1):121-31. doi: 10.1513/pats.201004-033RN. PMID: 21364230
Novel treatment of atrophic rhinitis: early results.
Jaswal A, Jana AK, Sikder B, Nandi TK, Sadhukhan SK, Das A
Eur Arch Otorhinolaryngol 2008 Oct;265(10):1211-7. Epub 2008 Mar 4 doi: 10.1007/s00405-008-0629-5. PMID: 18317788
Atrophic rhinitis.
Shehata MA
Am J Otolaryngol 1996 Mar-Apr;17(2):81-6. doi: 10.1016/s0196-0709(96)90000-9. PMID: 8820180
Surgical treatment of primary chronic atrophic rhinitis (an evaluation of silastic implants).
Shehata M, Dogheim Y
J Laryngol Otol 1986 Jul;100(7):803-7. doi: 10.1017/s0022215100100106. PMID: 3734599

Clinical prediction guides

Tissue specific stem cell therapy for airway regeneration.
Park DB, Lee JY, Kim SW, Kim DH
Cell Prolif 2024 Oct;57(10):e13662. Epub 2024 May 27 doi: 10.1111/cpr.13662. PMID: 38803033Free PMC Article
Surgical interventions for inferior turbinate hypertrophy.
Jwad AA, Albualih WA, Mahdi AK
J Popul Ther Clin Pharmacol 2022;28(2):e78-e82. Epub 2022 Jan 21 doi: 10.47750/jptcp.2022.861. PMID: 35213106
Inferior Meatus Augmentation Procedure (IMAP) to Treat Empty Nose Syndrome: A Pilot Study.
Thamboo A, Dholakia SS, Borchard NA, Patel VS, Tangbumrungtham N, Velasquez N, Huang Z, Zarabanda D, Nakayama T, Nayak JV
Otolaryngol Head Neck Surg 2020 Mar;162(3):382-385. Epub 2020 Jan 14 doi: 10.1177/0194599819900263. PMID: 31935161
Repair of nasal septal perforation using middle turbinate flap (monopedicled superiory based bone included conchal flap): a new unilateral middle turbinate mucosal flap technique.
Hanci D, Altun H
Eur Arch Otorhinolaryngol 2015 Jul;272(7):1707-12. Epub 2014 Sep 5 doi: 10.1007/s00405-014-3266-1. PMID: 25190253
Surfactant and its role in chronic sinusitis.
Schlosser RJ
Ann Otol Rhinol Laryngol Suppl 2006 Sep;196:40-4. doi: 10.1177/00034894061150s907. PMID: 17040017

Recent systematic reviews

A Systematic Review and Meta-Analysis of Management Options for Empty Nose Syndrome: A Proposed Management Algorithm.
Hussain S, Hayat J, Almhanedi H, Alherz M, Ebrahim M, Lari A, Thamboo A
Otolaryngol Head Neck Surg 2025 Jan;172(1):1-12. Epub 2024 Aug 10 doi: 10.1002/ohn.929. PMID: 39126290
A systematic review of the evidence base for vidian neurectomy in managing rhinitis.
Marshak T, Yun WK, Hazout C, Sacks R, Harvey RJ
J Laryngol Otol 2016 Jul;130 Suppl 4:S7-S28. doi: 10.1017/S0022215116008008. PMID: 27488341
The clinical efficacy of surgical interventions for empty nose syndrome: A systematic review.
Leong SC
Laryngoscope 2015 Jul;125(7):1557-62. Epub 2015 Feb 3 doi: 10.1002/lary.25170. PMID: 25647010
Interventions for atrophic rhinitis.
Mishra A, Kawatra R, Gola M
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD008280. doi: 10.1002/14651858.CD008280.pub2. PMID: 22336840Free PMC Article
Do chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic review.
Boyce J, Eccles R
Clin Otolaryngol 2006 Feb;31(1):15-9. doi: 10.1111/j.1749-4486.2006.01125.x. PMID: 16441795

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