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Rhinophyma

MedGen UID:
48451
•Concept ID:
C0035466
•
Disease or Syndrome
Synonym: Rhinophymas
SNOMED CT: Rhinophyma (19877001)
 
Monarch Initiative: MONDO:0043777

Definition

Progressive enlargement of the nose due to hypertrophy of the sebaceous glands of the tip of the nose and fibrosis. It usually affects older men and is associated with long-standing acne rosacea. It presents as a pink lobulated mass with dilated vessels in the nose. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhinophyma

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Rosacea management: A comprehensive review.
Sharma A, Kroumpouzos G, Kassir M, Galadari H, Goren A, Grabbe S, Goldust M
J Cosmet Dermatol 2022 May;21(5):1895-1904. Epub 2022 Feb 14 doi: 10.1111/jocd.14816. PMID: 35104917
Swiss S1 guideline for the treatment of rosacea.
Anzengruber F, Czernielewski J, Conrad C, Feldmeyer L, Yawalkar N, Häusermann P, Cozzio A, Mainetti C, Goldblum D, Läuchli S, Imhof L, Brand C, Laffitte E, Navarini AA
J Eur Acad Dermatol Venereol 2017 Nov;31(11):1775-1791. Epub 2017 Aug 21 doi: 10.1111/jdv.14349. PMID: 28833645

Recent clinical studies

Etiology

Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM
Immunity 2022 Oct 11;55(10):1891-1908.e12. Epub 2022 Aug 30 doi: 10.1016/j.immuni.2022.08.001. PMID: 36044899Free PMC Article
Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience.
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC
J Am Acad Dermatol 2019 Jun;80(6):1722-1729.e7. Epub 2018 Sep 19 doi: 10.1016/j.jaad.2018.08.049. PMID: 30240779
Procedural management of rhinophyma: A comprehensive review.
Krausz AE, Goldberg DJ, Ciocon DH, Tinklepaugh AJ
J Cosmet Dermatol 2018 Dec;17(6):960-967. Epub 2018 Sep 17 doi: 10.1111/jocd.12770. PMID: 30225926
Rhinophyma: A Treatment Review.
Fink C, Lackey J, Grande DJ
Dermatol Surg 2018 Feb;44(2):275-282. doi: 10.1097/DSS.0000000000001406. PMID: 29140869
Rosacea and rhinophyma in the elderly.
Wollina U
Clin Dermatol 2011 Jan-Feb;29(1):61-8. doi: 10.1016/j.clindermatol.2010.07.009. PMID: 21146734

Diagnosis

Rosacea.
Searle T, Al-Niaimi F, Ali FR
Br J Hosp Med (Lond) 2021 Feb 2;82(2):1-8. Epub 2021 Feb 27 doi: 10.12968/hmed.2020.0417. PMID: 33646026
Giant Rhinophyma.
Wang Y, Allen PW
Adv Anat Pathol 2020 Nov;27(6):422-424. doi: 10.1097/PAP.0000000000000282. PMID: 33027095
Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience.
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC
J Am Acad Dermatol 2019 Jun;80(6):1722-1729.e7. Epub 2018 Sep 19 doi: 10.1016/j.jaad.2018.08.049. PMID: 30240779
Rosacea and rhinophyma.
Tüzün Y, Wolf R, Kutlubay Z, Karakuş O, Engin B
Clin Dermatol 2014 Jan-Feb;32(1):35-46. doi: 10.1016/j.clindermatol.2013.05.024. PMID: 24314376
Acne rosacea.
Thiboutot DM
Am Fam Physician 1994 Dec;50(8):1691-7, 1701-2. PMID: 7976999

Therapy

Rosacea management: A comprehensive review.
Sharma A, Kroumpouzos G, Kassir M, Galadari H, Goren A, Grabbe S, Goldust M
J Cosmet Dermatol 2022 May;21(5):1895-1904. Epub 2022 Feb 14 doi: 10.1111/jocd.14816. PMID: 35104917
Rosacea.
Searle T, Al-Niaimi F, Ali FR
Br J Hosp Med (Lond) 2021 Feb 2;82(2):1-8. Epub 2021 Feb 27 doi: 10.12968/hmed.2020.0417. PMID: 33646026
Rhinophyma: A Treatment Review.
Fink C, Lackey J, Grande DJ
Dermatol Surg 2018 Feb;44(2):275-282. doi: 10.1097/DSS.0000000000001406. PMID: 29140869
Rosacea.
van Zuuren EJ
N Engl J Med 2017 Nov 2;377(18):1754-1764. doi: 10.1056/NEJMcp1506630. PMID: 29091565
Rosacea and rhinophyma.
Tüzün Y, Wolf R, Kutlubay Z, Karakuş O, Engin B
Clin Dermatol 2014 Jan-Feb;32(1):35-46. doi: 10.1016/j.clindermatol.2013.05.024. PMID: 24314376

Prognosis

Laser surgery in rhinophyma.
Bassi A, Campolmi P, Dindelli M, Bruscino N, Conti R, Cannarozzo G, Pimpinelli N
G Ital Dermatol Venereol 2016 Feb;151(1):9-16. Epub 2014 Sep 18 PMID: 25236318
New rhinophyma severity index and mid-term results following shave excision of rhinophyma.
Wetzig T, Averbeck M, Simon JC, Kendler M
Dermatology 2013;227(1):31-6. Epub 2013 Aug 30 doi: 10.1159/000351556. PMID: 24008235
Rosacea and its management: an overview.
Gupta AK, Chaudhry MM
J Eur Acad Dermatol Venereol 2005 May;19(3):273-85. doi: 10.1111/j.1468-3083.2005.01216.x. PMID: 15857452
Treatment of rhinophyma with Er:YAG laser.
Orenstein A, Haik J, Tamir J, Winkler E, Frand J, Zilinsky I, Kaplan H
Lasers Surg Med 2001;29(3):230-5. doi: 10.1002/lsm.1112. PMID: 11573224
Clinical and histological variants of rhinophyma, including nonsurgical treatment modalities.
Jansen T, Plewig G
Facial Plast Surg 1998;14(4):241-53. doi: 10.1055/s-2008-1064456. PMID: 11816064

Clinical prediction guides

Surgical treatment of rhinophyma: Retrospective monocentric study and literature review.
Dugourd PM, Guillot P, Beylot-Barry M, Cogrel O
Ann Dermatol Venereol 2021 Sep;148(3):172-176. Epub 2021 Jun 24 doi: 10.1016/j.annder.2021.02.004. PMID: 34176641
Laser and Light-Based Aesthetics in Men.
Green JB, Metelitsa AI, Kaufman J, Keaney T
J Drugs Dermatol 2015 Sep;14(9):1061-4. PMID: 26355628
Rosacea: 244 Tunisian cases.
Khaled A, Hammami H, Zeglaoui F, Tounsi J, Zermani R, Kamoun MR, Fazaa B
Tunis Med 2010 Aug;88(8):597-601. PMID: 20711968
The management of rosacea.
Rebora A
Am J Clin Dermatol 2002;3(7):489-96. doi: 10.2165/00128071-200203070-00005. PMID: 12180896
Diagnosis and treatment of rosacea.
Cohen AF, Tiemstra JD
J Am Board Fam Pract 2002 May-Jun;15(3):214-7. PMID: 12038728

Recent systematic reviews

Alcohol consumption and the risk of rosacea: A systematic review and meta-analysis.
Liu L, Xue Y, Chen Y, Pu Y, Zhang Y, Zhang L, Shao X, Chen J, Chen J
J Cosmet Dermatol 2022 Jul;21(7):2954-2961. Epub 2021 Sep 28 doi: 10.1111/jocd.14483. PMID: 34582097
Treatment of sebaceous gland hyperplasia: a review of the literature.
Hussein L, Perrett CM
J Dermatolog Treat 2021 Dec;32(8):866-877. Epub 2020 Apr 13 doi: 10.1080/09546634.2020.1720582. PMID: 32011918

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