U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Methylphenidate response

MedGen UID:
488590
•Concept ID:
CN165241
•
Sign or Symptom
Synonyms: Concerta response; Ritalin response
Drug:
Methylphenidate
MedGen UID:
6360
•Concept ID:
C0025810
•
Pharmacologic Substance
A synthetic central nervous system stimulant. Methylphenidate appears to activate the brain stem arousal system and cortex to produce its stimulant effect and, in some clinical settings, may improve cognitive function. [from NCI]
Methylphenidate

Professional guidelines

PubMed

Evidence-based pharmacological treatment options for ADHD in children and adolescents.
Mechler K, Banaschewski T, Hohmann S, Häge A
Pharmacol Ther 2022 Feb;230:107940. Epub 2021 Jun 23 doi: 10.1016/j.pharmthera.2021.107940. PMID: 34174276
Practical considerations for the evaluation and management of Attention Deficit Hyperactivity Disorder (ADHD) in adults.
Weibel S, Menard O, Ionita A, Boumendjel M, Cabelguen C, Kraemer C, Micoulaud-Franchi JA, Bioulac S, Perroud N, Sauvaget A, Carton L, Gachet M, Lopez R
Encephale 2020 Feb;46(1):30-40. Epub 2019 Oct 11 doi: 10.1016/j.encep.2019.06.005. PMID: 31610922
Diagnosis and management of ADHD in children.
Felt BT, Biermann B, Christner JG, Kochhar P, Harrison RV
Am Fam Physician 2014 Oct 1;90(7):456-64. PMID: 25369623

Curated

DailyMed Drug label, CONCERTA (methylphenidate hydrochloride) tablet, extended release, 2022

DailyMed Drug Label, methylphenidate, 2011

Recent clinical studies

Etiology

Electroencephalographic biomarkers as predictors of methylphenidate response in attention-deficit/hyperactivity disorder.
Arns M, Vollebregt MA, Palmer D, Spooner C, Gordon E, Kohn M, Clarke S, Elliott GR, Buitelaar JK
Eur Neuropsychopharmacol 2018 Aug;28(8):881-891. Epub 2018 Jun 22 doi: 10.1016/j.euroneuro.2018.06.002. PMID: 29937325
Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.
Angyal N, Horvath EZ, Tarnok Z, Richman MJ, Bognar E, Lakatos K, Sasvari-Szekely M, Nemoda Z
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(Pt A):122-128. Epub 2018 Feb 20 doi: 10.1016/j.pnpbp.2018.01.013. PMID: 29374517
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder.
Pagerols M, Richarte V, Sánchez-Mora C, Garcia-Martínez I, Corrales M, Corominas M, Cormand B, Casas M, Ribasés M, Ramos-Quiroga JA
Pharmacogenomics J 2017 Jan;17(1):98-104. Epub 2016 Jan 26 doi: 10.1038/tpj.2015.89. PMID: 26810137
Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD.
Lee SH, Kim SW, Lee MG, Yook KH, Greenhill LL, Fradin KN, Hong HJ
Psychiatry Res 2011 Apr 30;186(2-3):338-44. Epub 2010 Sep 21 doi: 10.1016/j.psychres.2010.08.033. PMID: 20863575
Anxiety, methylphenidate response, and working memory in children with ADHD.
Bedard AC, Tannock R
J Atten Disord 2008 Mar;11(5):546-57. Epub 2007 Dec 19 doi: 10.1177/1087054707311213. PMID: 18094325

Diagnosis

High Familial Correlation in Methylphenidate Response and Side Effect Profile.
Gazer-Snitovsky M, Brand-Gothelf A, Dubnov-Raz G, Weizman A, Gothelf D
J Atten Disord 2019 Jan;23(2):135-139. Epub 2015 Apr 21 doi: 10.1177/1087054715580844. PMID: 25899797
Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.
Angyal N, Horvath EZ, Tarnok Z, Richman MJ, Bognar E, Lakatos K, Sasvari-Szekely M, Nemoda Z
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(Pt A):122-128. Epub 2018 Feb 20 doi: 10.1016/j.pnpbp.2018.01.013. PMID: 29374517
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder.
Pagerols M, Richarte V, Sánchez-Mora C, Garcia-Martínez I, Corrales M, Corominas M, Cormand B, Casas M, Ribasés M, Ramos-Quiroga JA
Pharmacogenomics J 2017 Jan;17(1):98-104. Epub 2016 Jan 26 doi: 10.1038/tpj.2015.89. PMID: 26810137
Biomarkers in the diagnosis of ADHD--promising directions.
Faraone SV, Bonvicini C, Scassellati C
Curr Psychiatry Rep 2014 Nov;16(11):497. doi: 10.1007/s11920-014-0497-1. PMID: 25298126
Adrenergic α2A receptor gene is not associated with methylphenidate response in adults with ADHD.
Contini V, Victor MM, Cerqueira CC, Polina ER, Grevet EH, Salgado CA, Karam RG, Vitola ES, Belmonte-de-Abreu P, Bau CH
Eur Arch Psychiatry Clin Neurosci 2011 Apr;261(3):205-11. Epub 2010 Nov 20 doi: 10.1007/s00406-010-0172-4. PMID: 21103886

Therapy

Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD.
D'Aiello B, Di Vara S, De Rossi P, Pretelli I, Vicari S, Menghini D
Int J Environ Res Public Health 2022 Jan 31;19(3) doi: 10.3390/ijerph19031640. PMID: 35162663Free PMC Article
High Familial Correlation in Methylphenidate Response and Side Effect Profile.
Gazer-Snitovsky M, Brand-Gothelf A, Dubnov-Raz G, Weizman A, Gothelf D
J Atten Disord 2019 Jan;23(2):135-139. Epub 2015 Apr 21 doi: 10.1177/1087054715580844. PMID: 25899797
Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.
Angyal N, Horvath EZ, Tarnok Z, Richman MJ, Bognar E, Lakatos K, Sasvari-Szekely M, Nemoda Z
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(Pt A):122-128. Epub 2018 Feb 20 doi: 10.1016/j.pnpbp.2018.01.013. PMID: 29374517
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder.
Pagerols M, Richarte V, Sánchez-Mora C, Garcia-Martínez I, Corrales M, Corominas M, Cormand B, Casas M, Ribasés M, Ramos-Quiroga JA
Pharmacogenomics J 2017 Jan;17(1):98-104. Epub 2016 Jan 26 doi: 10.1038/tpj.2015.89. PMID: 26810137
Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD.
Lee SH, Kim SW, Lee MG, Yook KH, Greenhill LL, Fradin KN, Hong HJ
Psychiatry Res 2011 Apr 30;186(2-3):338-44. Epub 2010 Sep 21 doi: 10.1016/j.psychres.2010.08.033. PMID: 20863575

Prognosis

Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD.
D'Aiello B, Di Vara S, De Rossi P, Pretelli I, Vicari S, Menghini D
Int J Environ Res Public Health 2022 Jan 31;19(3) doi: 10.3390/ijerph19031640. PMID: 35162663Free PMC Article
Predictive Value of Slow and Fast EEG Oscillations for Methylphenidate Response in ADHD.
Sari Gokten E, Tulay EE, Beser B, Elagoz Yuksel M, Arikan K, Tarhan N, Metin B
Clin EEG Neurosci 2019 Sep;50(5):332-338. Epub 2019 Jul 15 doi: 10.1177/1550059419863206. PMID: 31304784
Electroencephalographic biomarkers as predictors of methylphenidate response in attention-deficit/hyperactivity disorder.
Arns M, Vollebregt MA, Palmer D, Spooner C, Gordon E, Kohn M, Clarke S, Elliott GR, Buitelaar JK
Eur Neuropsychopharmacol 2018 Aug;28(8):881-891. Epub 2018 Jun 22 doi: 10.1016/j.euroneuro.2018.06.002. PMID: 29937325
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder.
Pagerols M, Richarte V, Sánchez-Mora C, Garcia-Martínez I, Corrales M, Corominas M, Cormand B, Casas M, Ribasés M, Ramos-Quiroga JA
Pharmacogenomics J 2017 Jan;17(1):98-104. Epub 2016 Jan 26 doi: 10.1038/tpj.2015.89. PMID: 26810137
Predicting Methylphenidate Response in ADHD Using Machine Learning Approaches.
Kim JW, Sharma V, Ryan ND
Int J Neuropsychopharmacol 2015 May 10;18(11):pyv052. doi: 10.1093/ijnp/pyv052. PMID: 25964505Free PMC Article

Clinical prediction guides

Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD.
D'Aiello B, Di Vara S, De Rossi P, Pretelli I, Vicari S, Menghini D
Int J Environ Res Public Health 2022 Jan 31;19(3) doi: 10.3390/ijerph19031640. PMID: 35162663Free PMC Article
Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.
Angyal N, Horvath EZ, Tarnok Z, Richman MJ, Bognar E, Lakatos K, Sasvari-Szekely M, Nemoda Z
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(Pt A):122-128. Epub 2018 Feb 20 doi: 10.1016/j.pnpbp.2018.01.013. PMID: 29374517
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder.
Pagerols M, Richarte V, Sánchez-Mora C, Garcia-Martínez I, Corrales M, Corominas M, Cormand B, Casas M, Ribasés M, Ramos-Quiroga JA
Pharmacogenomics J 2017 Jan;17(1):98-104. Epub 2016 Jan 26 doi: 10.1038/tpj.2015.89. PMID: 26810137
Predicting Methylphenidate Response in ADHD Using Machine Learning Approaches.
Kim JW, Sharma V, Ryan ND
Int J Neuropsychopharmacol 2015 May 10;18(11):pyv052. doi: 10.1093/ijnp/pyv052. PMID: 25964505Free PMC Article
Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD.
Lee SH, Kim SW, Lee MG, Yook KH, Greenhill LL, Fradin KN, Hong HJ
Psychiatry Res 2011 Apr 30;186(2-3):338-44. Epub 2010 Sep 21 doi: 10.1016/j.psychres.2010.08.033. PMID: 20863575

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...