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Glomus tumor

MedGen UID:
4903
Concept ID:
C0017653
Neoplastic Process
Synonyms: Glomus Tumor; Glomus Tumors; Tumor, Glomus; Tumors, Glomus
 
Monarch Initiative: MONDO:0018327
Orphanet: ORPHA391651

Definition

A rare soft tissue tumor characterized by a nodular lesion composed of cells closely resembling the modified smooth muscle cells of the normal glomus body. The tumors most often arise in the skin or soft tissues of the distal extremities, in particular the subungual region, but have been reported in almost any location. They occur as typical glomus tumors, glomangiomatosis (multiple nodules of solid glomus tumor investing the vascular walls), symplastic (showing striking nuclear atypia without mitotic activity or necrosis) or malignant glomus tumors, and glomus tumors of uncertain malignant potential. [from ORDO]

Professional guidelines

PubMed

Curtis KL, Ho B, Jellinek NJ, Rubin AI, Tosti A, Lipner SR
J Am Acad Dermatol 2024 Sep;91(3):480-489. Epub 2024 May 3 doi: 10.1016/j.jaad.2024.04.032. PMID: 38705197
Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456
Wanna GB, Sweeney AD, Haynes DS, Carlson ML
Otolaryngol Clin North Am 2015 Apr;48(2):331-41. doi: 10.1016/j.otc.2014.12.007. PMID: 25769354

Recent clinical studies

Etiology

Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Paral KM, Petronic-Rosic V
Clin Dermatol 2017 Jan-Feb;35(1):85-98. Epub 2016 Sep 10 doi: 10.1016/j.clindermatol.2016.09.012. PMID: 27938817
Wanna GB, Sweeney AD, Haynes DS, Carlson ML
Otolaryngol Clin North Am 2015 Apr;48(2):331-41. doi: 10.1016/j.otc.2014.12.007. PMID: 25769354
Mravic M, LaChaud G, Nguyen A, Scott MA, Dry SM, James AW
Int J Surg Pathol 2015 May;23(3):181-8. Epub 2015 Jan 22 doi: 10.1177/1066896914567330. PMID: 25614464Free PMC Article
Manolidis S, Shohet JA, Jackson CG, Glasscock ME 3rd
Laryngoscope 1999 Jan;109(1):30-4. doi: 10.1097/00005537-199901000-00007. PMID: 9917036

Diagnosis

Sethu C, Sethu AU
Ann R Coll Surg Engl 2016 Jan;98(1):e1-2. doi: 10.1308/rcsann.2016.0005. PMID: 26688416Free PMC Article
Ebinu JO, Shahideh M, Ibrahim GM, Vescan A, Gentili F, Ridout R, Asa S, Zadeh G
Endocr Pathol 2011 Dec;22(4):218-21. doi: 10.1007/s12022-011-9179-2. PMID: 21912963
Gombos Z, Zhang PJ
Arch Pathol Lab Med 2008 Sep;132(9):1448-52. doi: 10.5858/2008-132-1448-GT. PMID: 18788860
McDermott EM, Weiss AP
J Hand Surg Am 2006 Oct;31(8):1397-400. doi: 10.1016/j.jhsa.2006.05.018. PMID: 17027805
Choi JJ, Murphey MD
Semin Musculoskelet Radiol 2000;4(1):103-12. doi: 10.1055/s-2000-6858. PMID: 11061695

Therapy

Wang J, Liu C, Ao W, An Y, Zhang W, Niu Z, Jia Y
J Int Med Res 2020 Aug;48(8):300060520936194. doi: 10.1177/0300060520936194. PMID: 32779507Free PMC Article
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
Pekic S, Popovic V
Eur J Endocrinol 2017 Jun;176(6):R269-R282. Epub 2017 Mar 3 doi: 10.1530/EJE-16-1065. PMID: 28258131
Ashour R, Aziz-Sultan A
Neurosurg Clin N Am 2014 Jul;25(3):607-17. Epub 2014 May 20 doi: 10.1016/j.nec.2014.04.015. PMID: 24994094
Dalfior D, Parisi A, Cannizzaro C, Bontempini L, Di Pace C, Menestrina F, Dalla Palma P, Barbareschi M
Int J Surg Pathol 2008 Jan;16(1):81-4. doi: 10.1177/1066896907304520. PMID: 18203793

Prognosis

Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Manolidis S, Shohet JA, Jackson CG, Glasscock ME 3rd
Laryngoscope 1999 Jan;109(1):30-4. doi: 10.1097/00005537-199901000-00007. PMID: 9917036
Diao E, Moy OJ
Orthop Clin North Am 1992 Jan;23(1):187-96. PMID: 1309601

Clinical prediction guides

Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Wanna GB, Sweeney AD, Haynes DS, Carlson ML
Otolaryngol Clin North Am 2015 Apr;48(2):331-41. doi: 10.1016/j.otc.2014.12.007. PMID: 25769354
Diao E, Moy OJ
Orthop Clin North Am 1992 Jan;23(1):187-96. PMID: 1309601
Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

Recent systematic reviews

Pansa A, Samà L, Ruspi L, Sicoli F, Cananzi FCM, Quagliuolo V
Dig Dis 2023;41(1):17-33. Epub 2022 Jun 26 doi: 10.1159/000525513. PMID: 35753305
Yuhan BT, Trang A, Hutz MJ, Leonetti JP
Otolaryngol Head Neck Surg 2020 Apr;162(4):458-468. Epub 2020 Feb 25 doi: 10.1177/0194599820907303. PMID: 32093508
Oliver JD, Boczar D, Huayllani MT, Restrepo DJ, Sisti A, Manrique OJ, Broer PN, Forte AJ
Ann Plast Surg 2019 Dec;83(6):e77-e84. doi: 10.1097/SAP.0000000000002004. PMID: 31599787
Park ES, Kim J, Jun SY
Head Neck 2017 Sep;39(9):1897-1909. Epub 2017 May 12 doi: 10.1002/hed.24818. PMID: 28497509

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