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Peptic esophagitis

MedGen UID:
5028
•Concept ID:
C0014869
•
Disease or Syndrome
Synonyms: Esophagitides, Peptic; Esophagitides, Reflux; Esophagitis, Peptic; Esophagitis, Reflux; Peptic Esophagitides; Peptic Esophagitis; Reflux Esophagitides; Reflux Esophagitis
 
Monarch Initiative: MONDO:0006896

Definition

Inflammation of the esophagus that is caused by the reflux of gastric juice with contents of the stomach and duodenum. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeptic esophagitis

Professional guidelines

PubMed

ACR Appropriateness Criteria® Epigastric Pain.
Expert Panel on Gastrointestinal Imaging, Vij A, Zaheer A, Kamel IR, Porter KK, Arif-Tiwari H, Bashir MR, Fung A, Goldstein A, Herr KD, Kamaya A, Kobi M, Landler MP, Russo GK, Thakrar KH, Turturro MA, Wahab SA, Wardrop RM 3rd, Wright CL, Yang X, Carucci LR
J Am Coll Radiol 2021 Nov;18(11S):S330-S339. doi: 10.1016/j.jacr.2021.08.006. PMID: 34794592
Current status of gastroesophageal reflux disease : diagnosis and treatment.
Chuang TW, Chen SC, Chen KT
Acta Gastroenterol Belg 2017 Jul-Sep;80(3):396-404. PMID: 29560670
Peptic esophagitis. Diagnosis and management.
CARNAZZO SJ, MANGIMELLI ST, CARNAZZO AJ
Nebr State Med J 1961 Aug;46:373-5. PMID: 13690876

Recent clinical studies

Etiology

Obesity, sleeve gastrectomy and gastro-esophageal reflux disease.
Veziant J, Benhalima S, Piessen G, Slim K
J Visc Surg 2023 Apr;160(2S):S47-S54. Epub 2023 Jan 30 doi: 10.1016/j.jviscsurg.2023.01.004. PMID: 36725450
Key Issues Associated with Helicobacter pylori Eradication.
Kawai T, Moriyasu F, Tsuchida A
Digestion 2016;93(1):19-23. Epub 2016 Jan 14 doi: 10.1159/000441667. PMID: 26788997
Gastroesophageal reflux disease revisited.
Fass R
Gastroenterol Clin North Am 2002 Dec;31(4 Suppl):S1-10. doi: 10.1016/s0889-8553(02)00046-8. PMID: 12489466
Ranitidine and depression.
Stocky A
Aust N Z J Psychiatry 1991 Sep;25(3):415-8. doi: 10.3109/00048679109062644. PMID: 1958166
Oxybutynin-induced reflux esophagitis.
Lee M, Sharifi R
DICP 1990 Jun;24(6):583-5. doi: 10.1177/106002809002400604. PMID: 2360335

Diagnosis

Obesity, sleeve gastrectomy and gastro-esophageal reflux disease.
Veziant J, Benhalima S, Piessen G, Slim K
J Visc Surg 2023 Apr;160(2S):S47-S54. Epub 2023 Jan 30 doi: 10.1016/j.jviscsurg.2023.01.004. PMID: 36725450
Diagnostic work-up of GERD.
Vela MF
Gastrointest Endosc Clin N Am 2014 Oct;24(4):655-66. Epub 2014 Jul 30 doi: 10.1016/j.giec.2014.07.002. PMID: 25216910
Barrett's esophagus, reflux esophagitis, and eosinophilic esophagitis.
Vleggaar FP, Siersema PD
Gastrointest Endosc 2012 Sep;76(3):496-500. doi: 10.1016/j.gie.2012.07.004. PMID: 22898406
Reflux esophagitis: overview.
Orlando RC
Scand J Gastroenterol Suppl 1995;210:36-7. doi: 10.3109/00365529509090267. PMID: 8578203
Reflux esophagitis. Diagnosis, pathophysiology, and management.
Crump WJ
Prim Care 1988 Mar;15(1):13-30. PMID: 3043493

Therapy

Comparative Efficacy of P-CAB vs Proton Pump Inhibitors for Grade C/D Esophagitis: A Systematic Review and Network Meta-analysis.
Zhuang Q, Chen S, Zhou X, Jia X, Zhang M, Tan N, Chen F, Zhang Z, Hu J, Xiao Y
Am J Gastroenterol 2024 May 1;119(5):803-813. Epub 2024 Feb 12 doi: 10.14309/ajg.0000000000002714. PMID: 38345252
Aciphex (rabeprazole).
Claussen DW
Gastroenterol Nurs 2000 Mar-Apr;23(2):88-9. doi: 10.1097/00001610-200003000-00011. PMID: 11111605
Omeprazole: a comprehensive review.
Massoomi F, Savage J, Destache CJ
Pharmacotherapy 1993 Jan-Feb;13(1):46-59. PMID: 8437967
Omeprazole.
Walan A
Baillieres Clin Gastroenterol 1988 Jul;2(3):629-40. doi: 10.1016/s0950-3528(88)80010-1. PMID: 3048454
Histamine H2-receptor antagonists.
Pounder R
Baillieres Clin Gastroenterol 1988 Jul;2(3):593-608. doi: 10.1016/s0950-3528(88)80007-1. PMID: 2901868

Prognosis

Changing from NAFLD to MASLD: Similar cumulative incidence of reflux esophagitis between NAFLD and MASLD.
Fukunaga S, Mukasa M, Nakano D, Tsutsumi T, Kawaguchi T
Clin Mol Hepatol 2024 Jan;30(1):121-123. Epub 2023 Dec 4 doi: 10.3350/cmh.2023.0437. PMID: 38044039Free PMC Article
Clinical Practice Update: The Use of Per-Oral Endoscopic Myotomy in Achalasia: Expert Review and Best Practice Advice From the AGA Institute.
Kahrilas PJ, Katzka D, Richter JE
Gastroenterology 2017 Nov;153(5):1205-1211. Epub 2017 Oct 6 doi: 10.1053/j.gastro.2017.10.001. PMID: 28989059Free PMC Article
Role of obesity in Barrett's esophagus and cancer.
Murray L, Romero Y
Surg Oncol Clin N Am 2009 Jul;18(3):439-52. doi: 10.1016/j.soc.2009.03.010. PMID: 19500735
Obesity and disease of the esophagus and colon.
El-Serag HB
Gastroenterol Clin North Am 2005 Mar;34(1):63-82. doi: 10.1016/j.gtc.2004.12.006. PMID: 15823439
Gastroesophageal reflux disease and obesity.
Shah A, Uribe J, Katz PO
Gastroenterol Clin North Am 2005 Mar;34(1):35-43. doi: 10.1016/j.gtc.2004.12.003. PMID: 15823437

Clinical prediction guides

Uncertainty-aware network for fine-grained and imbalanced reflux esophagitis grading.
Li X, Wu Q, Wang M, Wu K
Comput Biol Med 2024 Jan;168:107751. Epub 2023 Nov 23 doi: 10.1016/j.compbiomed.2023.107751. PMID: 38016373
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990
The ontogeny of saliva secretion in infants and esophagoprotection.
Collares EF, Fernandes MI
Arq Gastroenterol 2015 Apr-Jun;52(2):156-60. doi: 10.1590/S0004-28032015000200016. PMID: 26039837
Helicobacter pylori and smoking: two additive risk factors for organic dyspepsia.
Halter F, Brignoli R
Yale J Biol Med 1998 Mar-Apr;71(2):91-9. PMID: 10378354Free PMC Article
Indications, benefits and outcome of laparoscopic Nissen fundoplication.
Peters JH, DeMeester TR
Dig Dis 1996 May-Jun;14(3):169-79. doi: 10.1159/000171548. PMID: 8861524

Recent systematic reviews

Comparative Efficacy of P-CAB vs Proton Pump Inhibitors for Grade C/D Esophagitis: A Systematic Review and Network Meta-analysis.
Zhuang Q, Chen S, Zhou X, Jia X, Zhang M, Tan N, Chen F, Zhang Z, Hu J, Xiao Y
Am J Gastroenterol 2024 May 1;119(5):803-813. Epub 2024 Feb 12 doi: 10.14309/ajg.0000000000002714. PMID: 38345252
Short-term outcomes and long-term quality of life of reconstruction methods after proximal gastrectomy: a systematic review and meta-analysis.
Li B, Wang Y, Li B, Shan F, Li Z
BMC Cancer 2024 Jan 10;24(1):56. doi: 10.1186/s12885-024-11827-4. PMID: 38200411Free PMC Article
Association Between Anxiety/Depression and Gastroesophageal Reflux: A Systematic Review and Meta-Analysis.
Zamani M, Alizadeh-Tabari S, Chan WW, Talley NJ
Am J Gastroenterol 2023 Dec 1;118(12):2133-2143. Epub 2023 Jul 19 doi: 10.14309/ajg.0000000000002411. PMID: 37463429
Vonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: A systematic review.
Miyazaki H, Igarashi A, Takeuchi T, Teng L, Uda A, Deguchi H, Higuchi K, Tango T
J Gastroenterol Hepatol 2019 Aug;34(8):1316-1328. Epub 2019 Apr 11 doi: 10.1111/jgh.14664. PMID: 30883868
Effectiveness of proton pump inhibitors in nonerosive reflux disease.
Dean BB, Gano AD Jr, Knight K, Ofman JJ, Fass R
Clin Gastroenterol Hepatol 2004 Aug;2(8):656-64. doi: 10.1016/s1542-3565(04)00288-5. PMID: 15290657

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