U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Capillary fragility

MedGen UID:
507522
•Concept ID:
C0006905
•
Disease or Syndrome
Synonyms: Capillary fragillity; Fragile capillaries
SNOMED CT: Capillary fragility (248725002); Capillary fragillity (248725002); Fragile capillaries (248726001)
 
HPO: HP:0025017

Definition

Reduced resistance to rupture of capillary blood vessels. Capillary fragility may manifest as a bleeding diathesis with spontaneous ecchymoses (bruises). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCapillary fragility

Professional guidelines

PubMed

Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Lymphedema treatment decreases pain intensity in lipedema.
Szolnoky G, Varga E, Varga M, Tuczai M, Dósa-Rácz E, Kemény L
Lymphology 2011 Dec;44(4):178-82. PMID: 22458119
Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium.
Quijano CE, Abalos E
Cochrane Database Syst Rev 2005 Jul 20;2005(3):CD004077. doi: 10.1002/14651858.CD004077.pub2. PMID: 16034920Free PMC Article

Recent clinical studies

Etiology

Thromboembolic and bleeding risk in cardiac amyloidosis.
Tana M, Tana C, Rossi D, Mantini C, Gallina S, Ricci F, Porreca E
J Thromb Haemost 2024 Sep;22(9):2381-2392. Epub 2024 May 27 doi: 10.1016/j.jtha.2024.05.018. PMID: 38810701
Risk factors associated with severe dengue in Latin America: A systematic review and meta-analysis.
Paraná VC, Feitosa CA, da Silva GCS, Gois LL, Santos LA
Trop Med Int Health 2024 Mar;29(3):173-191. Epub 2024 Jan 23 doi: 10.1111/tmi.13968. PMID: 38263345
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
What type of valve is most appropriate for osteogenesis imperfecta patients?
Dimitrakakis G, Challoumas D, von Oppell UO
Interact Cardiovasc Thorac Surg 2014 Sep;19(3):499-504. Epub 2014 May 29 doi: 10.1093/icvts/ivu152. PMID: 24876219
Bleeding and bruising in patients with Ehlers-Danlos syndrome and other collagen vascular disorders.
De Paepe A, Malfait F
Br J Haematol 2004 Dec;127(5):491-500. doi: 10.1111/j.1365-2141.2004.05220.x. PMID: 15566352

Diagnosis

Thromboembolic and bleeding risk in cardiac amyloidosis.
Tana M, Tana C, Rossi D, Mantini C, Gallina S, Ricci F, Porreca E
J Thromb Haemost 2024 Sep;22(9):2381-2392. Epub 2024 May 27 doi: 10.1016/j.jtha.2024.05.018. PMID: 38810701
Risk factors associated with severe dengue in Latin America: A systematic review and meta-analysis.
Paraná VC, Feitosa CA, da Silva GCS, Gois LL, Santos LA
Trop Med Int Health 2024 Mar;29(3):173-191. Epub 2024 Jan 23 doi: 10.1111/tmi.13968. PMID: 38263345
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
Lava SAG, Milani GP, Fossali EF, Simonetti GD, Agostoni C, Bianchetti MG
Clin Rev Allergy Immunol 2017 Dec;53(3):439-451. doi: 10.1007/s12016-017-8626-3. PMID: 28836099
What type of valve is most appropriate for osteogenesis imperfecta patients?
Dimitrakakis G, Challoumas D, von Oppell UO
Interact Cardiovasc Thorac Surg 2014 Sep;19(3):499-504. Epub 2014 May 29 doi: 10.1093/icvts/ivu152. PMID: 24876219

Therapy

Thromboembolic and bleeding risk in cardiac amyloidosis.
Tana M, Tana C, Rossi D, Mantini C, Gallina S, Ricci F, Porreca E
J Thromb Haemost 2024 Sep;22(9):2381-2392. Epub 2024 May 27 doi: 10.1016/j.jtha.2024.05.018. PMID: 38810701
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
What type of valve is most appropriate for osteogenesis imperfecta patients?
Dimitrakakis G, Challoumas D, von Oppell UO
Interact Cardiovasc Thorac Surg 2014 Sep;19(3):499-504. Epub 2014 May 29 doi: 10.1093/icvts/ivu152. PMID: 24876219
Negative pressure pulmonary edema.
Louis PJ, Fernandes R
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Jan;93(1):4-6. doi: 10.1067/moe.2002.119909. PMID: 11805770
Bleeding in uremia.
Rabiner SF
Med Clin North Am 1972 Jan;56(1):221-33. doi: 10.1016/s0025-7125(16)32437-3. PMID: 4550291

Prognosis

Lymphedema treatment decreases pain intensity in lipedema.
Szolnoky G, Varga E, Varga M, Tuczai M, Dósa-Rácz E, Kemény L
Lymphology 2011 Dec;44(4):178-82. PMID: 22458119
Complex decongestive physiotherapy decreases capillary fragility in lipedema.
Szolnoky G, Nagy N, Kovács RK, Dósa-Rácz E, Szabó A, Bársony K, Balogh M, Kemény L
Lymphology 2008 Dec;41(4):161-6. PMID: 19306662
Vocal nodules and edema may be due to vibration-induced rises in capillary pressure.
Czerwonka L, Jiang JJ, Tao C
Laryngoscope 2008 Apr;118(4):748-52. doi: 10.1097/MLG.0b013e31815fdeee. PMID: 18300711Free PMC Article
Pathogenesis, early diagnosis, and prophylaxis for chronic hemophilic synovitis.
Rodríguez-Merchán EC
Clin Orthop Relat Res 1997 Oct;(343):6-11. PMID: 9345198
Capillary fragility studies in diabetes.
Hart A, Cohen H
Br Med J 1969 Apr 12;2(5649):89-91. doi: 10.1136/bmj.2.5649.89. PMID: 5775455Free PMC Article

Clinical prediction guides

Fragility of pulmonary capillaries.
West JB
J Appl Physiol (1985) 2013 Jul 1;115(1):1-15. Epub 2013 May 2 doi: 10.1152/japplphysiol.00229.2013. PMID: 23640584
Connective tissue and vascular phenotype in patients with cervical artery dissection.
Dittrich R, Heidbreder A, Rohsbach D, Schmalhorst J, Nassenstein I, Maintz D, Ringelstein EB, Nabavi DG, Kuhlenbäumer G
Neurology 2007 Jun 12;68(24):2120-4. doi: 10.1212/01.wnl.0000264892.92538.a9. PMID: 17562832
Bleeding and bruising in patients with Ehlers-Danlos syndrome and other collagen vascular disorders.
De Paepe A, Malfait F
Br J Haematol 2004 Dec;127(5):491-500. doi: 10.1111/j.1365-2141.2004.05220.x. PMID: 15566352
Bleeding time at altitude.
Doughty HA, Beardmore C
J R Soc Med 1994 Jun;87(6):317-9. doi: 10.1177/014107689408700605. PMID: 7605410Free PMC Article
Haemostatic studies in osteogenesis imperfecta.
Evensen SA, Myhre L, Stormorken H
Scand J Haematol 1984 Aug;33(2):177-9. doi: 10.1111/j.1600-0609.1984.tb02393.x. PMID: 6474094

Recent systematic reviews

Risk factors associated with severe dengue in Latin America: A systematic review and meta-analysis.
Paraná VC, Feitosa CA, da Silva GCS, Gois LL, Santos LA
Trop Med Int Health 2024 Mar;29(3):173-191. Epub 2024 Jan 23 doi: 10.1111/tmi.13968. PMID: 38263345
Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis.
Zhang X, Liu W, Wu S, Jin J, Li W, Wang N
Sci China Life Sci 2015 Jan;58(1):101-7. Epub 2014 Dec 20 doi: 10.1007/s11427-014-4792-1. PMID: 25528255
Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium.
Quijano CE, Abalos E
Cochrane Database Syst Rev 2005 Jul 20;2005(3):CD004077. doi: 10.1002/14651858.CD004077.pub2. PMID: 16034920Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...