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Nummular eczema

MedGen UID:
508353
•Concept ID:
C0085656
•
Disease or Syndrome
Synonyms: Discoid eczema; Nummular dermatitis; Nummular eczematous dermatitis
SNOMED CT: Nummular eczema (81418003); Nummular dermatitis (81418003); Nummular eczematous dermatitis (81418003); Discoid eczema (81418003)
 
HPO: HP:0033120

Definition

A type of eczema characterized by pruritic coin-shaped patches on the skin. Nummular eczema most commonly occurs on the extremities, particularly the legs, but may occur anywhere on the trunk, hands, or feet [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNummular eczema

Professional guidelines

PubMed

Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021
Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Nummular eczema during isotretinoin treatment.
Bettoli V, Tosti A, Varotti C
J Am Acad Dermatol 1987 Mar;16(3 Pt 1):617. doi: 10.1016/s0190-9622(87)80093-2. PMID: 2950149

Recent clinical studies

Etiology

Prevalence and trend of allergen sensitization in patients with nummular (discoid) eczema referred for patch testing: North American Contact Dermatitis Group data, 2001-2016.
Silverberg JI, Hou A, Warshaw EM, Maibach HI, Belsito DV, DeKoven JG, Zug KA, Taylor JS, Sasseville D, Fransway AF, DeLeo VA, Pratt MD, Reeder MJ, Atwater AR, Fowler JF Jr, Zirwas MJ, Marks JG Jr
Contact Dermatitis 2021 Jul;85(1):46-57. Epub 2021 Mar 16 doi: 10.1111/cod.13824. PMID: 33634511
FACTORS CONTRIBUTING TO CHRONIC URTICARIA/ANGIOEDEMA AND NUMMULAR ECZEMA RESOLUTION - WHICH FINDINGS ARE CRUCIAL?
Lugović-Mihić L, Bukvić I, Bulat V, Japundžić I
Acta Clin Croat 2019 Dec;58(4):595-603. doi: 10.20471/acc.2019.58.04.05. PMID: 32595243Free PMC Article
Methotrexate for severe nummular eczema in children: Efficacy and tolerability in a retrospective study of 28 patients.
Knöpfel N, Noguera-Morel L, Hernández-Martín A, Torrelo A
Pediatr Dermatol 2018 Sep;35(5):611-615. Epub 2018 Jun 26 doi: 10.1111/pde.13568. PMID: 29943852
Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma.
Wong HK
Discov Med 2013 Sep;16(87):71-8. PMID: 23998443
Nummular eczema and contact allergy: a retrospective study.
Bonamonte D, Foti C, Vestita M, Ranieri LD, Angelini G
Dermatitis 2012 Jul-Aug;23(4):153-7. doi: 10.1097/DER.0b013e318260d5a0. PMID: 22828253

Diagnosis

Discoid (nummular) eczema in the paediatric setting - An Australian/New Zealand narrative.
McWhirter S, Foster R, Halbert A, Miller R, Morgan VA, Rademaker M, Robertson S, Scardamaglia L, Warren L, Wong LC, Zappala T, Orchard D
Australas J Dermatol 2022 Nov;63(4):e289-e296. Epub 2022 Sep 4 doi: 10.1111/ajd.13915. PMID: 36057946
Nummular Eczema: An Updated Review.
Leung AKC, Lam JM, Leong KF, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):146-155. doi: 10.2174/1872213X14666200810152246. PMID: 32778043
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021
Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Nummular eczema.
Halberg M
J Emerg Med 2012 Nov;43(5):e327-8. Epub 2011 Jun 29 doi: 10.1016/j.jemermed.2011.05.031. PMID: 21719233

Therapy

Topical and Oral Roflumilast in Dermatology: A Narrative Review.
Mansilla-Polo M, Gimeno E, Morgado-Carrasco D
Actas Dermosifiliogr 2024 Mar;115(3):265-279. Epub 2023 Sep 12 doi: 10.1016/j.ad.2023.09.005. PMID: 37709133
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Nummular Eczema: An Updated Review.
Leung AKC, Lam JM, Leong KF, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):146-155. doi: 10.2174/1872213X14666200810152246. PMID: 32778043
Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Nummular eczema.
Halberg M
J Emerg Med 2012 Nov;43(5):e327-8. Epub 2011 Jun 29 doi: 10.1016/j.jemermed.2011.05.031. PMID: 21719233

Prognosis

Discoid (nummular) eczema in the paediatric setting - An Australian/New Zealand narrative.
McWhirter S, Foster R, Halbert A, Miller R, Morgan VA, Rademaker M, Robertson S, Scardamaglia L, Warren L, Wong LC, Zappala T, Orchard D
Australas J Dermatol 2022 Nov;63(4):e289-e296. Epub 2022 Sep 4 doi: 10.1111/ajd.13915. PMID: 36057946
Nummular Eczema: An Updated Review.
Leung AKC, Lam JM, Leong KF, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):146-155. doi: 10.2174/1872213X14666200810152246. PMID: 32778043
Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.
Ion A, Popa IM, Papagheorghe LM, Lisievici C, Lupu M, Voiculescu V, Caruntu C, Boda D
Dis Markers 2016;2016:9602472. Epub 2016 Oct 16 doi: 10.1155/2016/9602472. PMID: 27821903Free PMC Article
Clinical features and aggravating factors in nummular eczema in Thais.
Jiamton S, Tangjaturonrusamee C, Kulthanan K
Asian Pac J Allergy Immunol 2013 Mar;31(1):36-42. PMID: 23517392

Clinical prediction guides

Nummular Eczema: An Updated Review.
Leung AKC, Lam JM, Leong KF, Leung AAM, Wong AHC, Hon KL
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):146-155. doi: 10.2174/1872213X14666200810152246. PMID: 32778043
Effectiveness of dupilumab for the treatment of nummular eczema phenotype of atopic dermatitis in adults.
Patruno C, Stingeni L, Hansel K, Ferrucci SM, Tavecchio S, Fabbrocini G, Nisticò SP, Foti C, De Prezzo S, Napolitano M
Dermatol Ther 2020 May;33(3):e13290. Epub 2020 Mar 11 doi: 10.1111/dth.13290. PMID: 32125741
Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.
Ion A, Popa IM, Papagheorghe LM, Lisievici C, Lupu M, Voiculescu V, Caruntu C, Boda D
Dis Markers 2016;2016:9602472. Epub 2016 Oct 16 doi: 10.1155/2016/9602472. PMID: 27821903Free PMC Article
Clinical features and aggravating factors in nummular eczema in Thais.
Jiamton S, Tangjaturonrusamee C, Kulthanan K
Asian Pac J Allergy Immunol 2013 Mar;31(1):36-42. PMID: 23517392
Vitiligo: clinical findings in 1436 patients.
Handa S, Kaur I
J Dermatol 1999 Oct;26(10):653-7. doi: 10.1111/j.1346-8138.1999.tb02067.x. PMID: 10554431

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