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Central retinal vein occlusion

MedGen UID:
509679
•Concept ID:
C0154841
•
Disease or Syndrome
Synonym: Central Retinal Vein Occlusion
SNOMED CT: Central retinal vein occlusion (68478007); CRVT - Central retinal vein thrombosis (68478007); CRVO - Central retinal vein occlusion (68478007); Central retinal vein thrombosis (68478007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0020166
Monarch Initiative: MONDO:0002303
Orphanet: ORPHA411527

Definition

Central retinal vein occlusion is an occlusion of the main retinal vein posterior to the lamina cribrosa of the optic nerve and is typically caused by thrombosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral retinal vein occlusion

Professional guidelines

PubMed

A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Central Retinal Vein Occlusion: A Review of Current Evidence-based Treatment Options.
Patel A, Nguyen C, Lu S
Middle East Afr J Ophthalmol 2016 Jan-Mar;23(1):44-8. doi: 10.4103/0974-9233.173132. PMID: 26957838Free PMC Article
Retinal vein thrombosis: pathogenesis and management.
Rehak M, Wiedemann P
J Thromb Haemost 2010 Sep;8(9):1886-94. doi: 10.1111/j.1538-7836.2010.03909.x. PMID: 20492457

Recent clinical studies

Etiology

Photocoagulation for retinal vein occlusion.
Hayreh SS
Prog Retin Eye Res 2021 Nov;85:100964. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100964. PMID: 33713810
Central retinal vein occlusion and pseudoexfoliation syndrome.
Karagiannis D, Kontadakis GA, Klados NE, Tsoumpris I, Kandarakis AS, Parikakis EA, Georgalas I, Tsilimbaris MK
Clin Interv Aging 2015;10:879-83. Epub 2015 May 20 doi: 10.2147/CIA.S77630. PMID: 26056437Free PMC Article
Central retinal vein occlusion: a review.
McAllister IL
Clin Exp Ophthalmol 2012 Jan-Feb;40(1):48-58. Epub 2011 Dec 6 doi: 10.1111/j.1442-9071.2011.02713.x. PMID: 22003973
Branch retinal vein occlusion.
Hamid S, Mirza SA, Shokh I
J Ayub Med Coll Abbottabad 2008 Apr-Jun;20(2):128-32. PMID: 19385476
Central retinal vein occlusion and thrombophilia.
Fegan CD
Eye (Lond) 2002 Jan;16(1):98-106. doi: 10.1038/sj.eye.6700040. PMID: 11913903

Diagnosis

COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19.
Sen M, Honavar SG, Sharma N, Sachdev MS
Indian J Ophthalmol 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. PMID: 33595463Free PMC Article
Central retinal vein occlusion and pseudoexfoliation syndrome.
Karagiannis D, Kontadakis GA, Klados NE, Tsoumpris I, Kandarakis AS, Parikakis EA, Georgalas I, Tsilimbaris MK
Clin Interv Aging 2015;10:879-83. Epub 2015 May 20 doi: 10.2147/CIA.S77630. PMID: 26056437Free PMC Article
Retinal vein occlusion: beyond the acute event.
Ehlers JP, Fekrat S
Surv Ophthalmol 2011 Jul-Aug;56(4):281-99. Epub 2011 May 24 doi: 10.1016/j.survophthal.2010.11.006. PMID: 21601903
Branch retinal vein occlusion.
Hamid S, Mirza SA, Shokh I
J Ayub Med Coll Abbottabad 2008 Apr-Jun;20(2):128-32. PMID: 19385476
Acute visual change.
Morgan A, Hemphill RR
Emerg Med Clin North Am 1998 Nov;16(4):825-43, vii. doi: 10.1016/s0733-8627(05)70035-3. PMID: 9889742

Therapy

Photocoagulation for retinal vein occlusion.
Hayreh SS
Prog Retin Eye Res 2021 Nov;85:100964. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100964. PMID: 33713810
Central Retinal Vein Occlusion: A Review of Current Evidence-based Treatment Options.
Patel A, Nguyen C, Lu S
Middle East Afr J Ophthalmol 2016 Jan-Mar;23(1):44-8. doi: 10.4103/0974-9233.173132. PMID: 26957838Free PMC Article
Central retinal vein occlusion: a review.
McAllister IL
Clin Exp Ophthalmol 2012 Jan-Feb;40(1):48-58. Epub 2011 Dec 6 doi: 10.1111/j.1442-9071.2011.02713.x. PMID: 22003973
Update and review of central retinal vein occlusion.
London NJ, Brown G
Curr Opin Ophthalmol 2011 May;22(3):159-65. doi: 10.1097/ICU.0b013e3283459737. PMID: 21460724
Retinal vein thrombosis: pathogenesis and management.
Rehak M, Wiedemann P
J Thromb Haemost 2010 Sep;8(9):1886-94. doi: 10.1111/j.1538-7836.2010.03909.x. PMID: 20492457

Prognosis

Ocular manifestations of pulmonary hypertension.
Lewczuk N, Zdebik A, Bogusławska J, Turno-Kręcicka A, Misiuk-Hojło M
Surv Ophthalmol 2019 Sep-Oct;64(5):694-699. Epub 2019 Mar 6 doi: 10.1016/j.survophthal.2019.02.009. PMID: 30849428
Mechanisms of macular edema: Beyond the surface.
Daruich A, Matet A, Moulin A, Kowalczuk L, Nicolas M, Sellam A, Rothschild PR, Omri S, Gélizé E, Jonet L, Delaunay K, De Kozak Y, Berdugo M, Zhao M, Crisanti P, Behar-Cohen F
Prog Retin Eye Res 2018 Mar;63:20-68. Epub 2017 Nov 7 doi: 10.1016/j.preteyeres.2017.10.006. PMID: 29126927
Central retinal vein occlusion: modifying current treatment protocols.
Ashraf M, Souka AA, Singh RP
Eye (Lond) 2016 Apr;30(4):505-14. Epub 2016 Feb 12 doi: 10.1038/eye.2016.10. PMID: 26869163Free PMC Article
Branch retinal vein occlusion.
Hamid S, Mirza SA, Shokh I
J Ayub Med Coll Abbottabad 2008 Apr-Jun;20(2):128-32. PMID: 19385476
Retinal vein occlusion.
Hayreh SS
Indian J Ophthalmol 1994 Sep;42(3):109-32. PMID: 7829175

Clinical prediction guides

COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19.
Sen M, Honavar SG, Sharma N, Sachdev MS
Indian J Ophthalmol 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. PMID: 33595463Free PMC Article
Use of Anti-VEGF Drugs in Retinal Vein Occlusions.
Vilela MA
Curr Drug Targets 2020;21(12):1181-1193. doi: 10.2174/1389450121666200428101343. PMID: 32342813
Ocular manifestations of pulmonary hypertension.
Lewczuk N, Zdebik A, Bogusławska J, Turno-Kręcicka A, Misiuk-Hojło M
Surv Ophthalmol 2019 Sep-Oct;64(5):694-699. Epub 2019 Mar 6 doi: 10.1016/j.survophthal.2019.02.009. PMID: 30849428
Central retinal vein occlusion: modifying current treatment protocols.
Ashraf M, Souka AA, Singh RP
Eye (Lond) 2016 Apr;30(4):505-14. Epub 2016 Feb 12 doi: 10.1038/eye.2016.10. PMID: 26869163Free PMC Article
Natural history of central retinal vein occlusion: an evidence-based systematic review.
McIntosh RL, Rogers SL, Lim L, Cheung N, Wang JJ, Mitchell P, Kowalski JW, Nguyen HP, Wong TY
Ophthalmology 2010 Jun;117(6):1113-1123.e15. doi: 10.1016/j.ophtha.2010.01.060. PMID: 20430446

Recent systematic reviews

Retinal oximetry in patients with ischaemic retinal diseases.
Rilvén S, Torp TL, Grauslund J
Acta Ophthalmol 2017 Mar;95(2):119-127. Epub 2016 Sep 1 doi: 10.1111/aos.13229. PMID: 27585711
Treatments for macular oedema following central retinal vein occlusion: systematic review.
Ford JA, Clar C, Lois N, Barton S, Thomas S, Court R, Shyangdan D, Waugh N
BMJ Open 2014 Feb 10;4(2):e004120. doi: 10.1136/bmjopen-2013-004120. PMID: 24513867Free PMC Article
Ocular ischemic syndrome - a systematic review.
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article
Natural history of central retinal vein occlusion: an evidence-based systematic review.
McIntosh RL, Rogers SL, Lim L, Cheung N, Wang JJ, Mitchell P, Kowalski JW, Nguyen HP, Wong TY
Ophthalmology 2010 Jun;117(6):1113-1123.e15. doi: 10.1016/j.ophtha.2010.01.060. PMID: 20430446
Interventions for central retinal vein occlusion: an evidence-based systematic review.
Mohamed Q, McIntosh RL, Saw SM, Wong TY
Ophthalmology 2007 Mar;114(3):507-19, 524. doi: 10.1016/j.ophtha.2006.11.011. PMID: 17324695

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