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Uterine Hemorrhage

MedGen UID:
52956
•Concept ID:
C0042134
•
Pathologic Function
Synonyms: Bleeding, Uterine; Hemorrhage, Uterine; Uterine Bleeding; Uterine Bleedings; Uterine Hemorrhages

Definition

Bleeding originating from the uterus. [from NCI]

Professional guidelines

PubMed

Postpartum Hemorrhage: Prevention and Treatment.
Evensen A, Anderson JM, Fontaine P
Am Fam Physician 2017 Apr 1;95(7):442-449. PMID: 28409600
Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management.
Erez O, Mastrolia SA, Thachil J
Am J Obstet Gynecol 2015 Oct;213(4):452-63. Epub 2015 Mar 31 doi: 10.1016/j.ajog.2015.03.054. PMID: 25840271
Prevention and treatment of uterine bleeding in hematologic malignancy.
Quaas AM, Ginsburg ES
Eur J Obstet Gynecol Reprod Biol 2007 Sep;134(1):3-8. Epub 2007 Apr 27 doi: 10.1016/j.ejogrb.2007.03.012. PMID: 17467142

Recent clinical studies

Etiology

Abnormal Uterine Bleeding in Premenopausal Women.
Wouk N, Helton M
Am Fam Physician 2019 Apr 1;99(7):435-443. PMID: 30932448
Adenomyosis and Abnormal Uterine Bleeding (AUB-A)-Pathogenesis, diagnosis, and management.
Abbott JA
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:68-81. Epub 2016 Sep 30 doi: 10.1016/j.bpobgyn.2016.09.006. PMID: 27810281
Resectoscopic myomectomy.
Mazzon I, Bettocchi S, Fascilla F, DE Palma D, Palma F, Zizolfi B, DI Spiezio Sardo A
Minerva Ginecol 2016 Jun;68(3):334-44. Epub 2016 Mar 23 PMID: 27008062
The FIGO classification of causes of abnormal uterine bleeding in the reproductive years.
Munro MG, Critchley HO, Fraser IS; FIGO Menstrual Disorders Working Group
Fertil Steril 2011 Jun;95(7):2204-8, 2208.e1-3. Epub 2011 Apr 15 doi: 10.1016/j.fertnstert.2011.03.079. PMID: 21496802
FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age.
Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders
Int J Gynaecol Obstet 2011 Apr;113(1):3-13. Epub 2011 Feb 22 doi: 10.1016/j.ijgo.2010.11.011. PMID: 21345435

Diagnosis

Abnormal Uterine Bleeding.
Lebduska E, Beshear D, Spataro BM
Med Clin North Am 2023 Mar;107(2):235-246. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.014. PMID: 36759094
Approach to Abnormal Uterine Bleeding in Adolescents.
Yaşa C, Güngör Uğurlucan F
J Clin Res Pediatr Endocrinol 2020 Feb 6;12(Suppl 1):1-6. doi: 10.4274/jcrpe.galenos.2019.2019.S0200. PMID: 32041387Free PMC Article
Abnormal Uterine Bleeding in Premenopausal Women.
Wouk N, Helton M
Am Fam Physician 2019 Apr 1;99(7):435-443. PMID: 30932448
Adenomyosis and Abnormal Uterine Bleeding (AUB-A)-Pathogenesis, diagnosis, and management.
Abbott JA
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:68-81. Epub 2016 Sep 30 doi: 10.1016/j.bpobgyn.2016.09.006. PMID: 27810281
FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age.
Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders
Int J Gynaecol Obstet 2011 Apr;113(1):3-13. Epub 2011 Feb 22 doi: 10.1016/j.ijgo.2010.11.011. PMID: 21345435

Therapy

Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P): What is the relationship, how are they diagnosed and how are they treated?
Clark TJ, Stevenson H
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:89-104. Epub 2016 Oct 1 doi: 10.1016/j.bpobgyn.2016.09.005. PMID: 27914969
Adenomyosis and Abnormal Uterine Bleeding (AUB-A)-Pathogenesis, diagnosis, and management.
Abbott JA
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:68-81. Epub 2016 Sep 30 doi: 10.1016/j.bpobgyn.2016.09.006. PMID: 27810281
Esmya(®) and the PEARL studies: A review.
Powell M, Dutta D
Womens Health (Lond) 2016 Nov;12(6):544-548. Epub 2017 Feb 13 doi: 10.1177/1745505717692591. PMID: 29334010Free PMC Article
Jaydess® levonorgestrel intrauterine system.
Melvin L, Scott J, Craik J
J Fam Plann Reprod Health Care 2014 Jul;40(3):165-9. doi: 10.1136/jfprhc-2014-100980. PMID: 24939481
Copper-bearing intrauterine devices.
Tatum HJ
Clin Obstet Gynecol 1974 Mar;17(1):93-119. doi: 10.1097/00003081-197403000-00011. PMID: 4604276

Prognosis

Management of abnormal uterine bleeding on anticoagulation: the patient-clinician perspective.
Samuelson Bannow BT
J Thromb Haemost 2024 Jul;22(7):1819-1825. Epub 2024 Apr 19 doi: 10.1016/j.jtha.2024.04.002. PMID: 38642705Free PMC Article
Applying Patient Safety to Reduce Maternal Mortality.
Baptiste C, D'Alton ME
Obstet Gynecol Clin North Am 2019 Jun;46(2):353-365. doi: 10.1016/j.ogc.2019.01.016. PMID: 31056136
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Evan's syndrome revisited.
Dave P, Krishna K, Diwan AG
J Assoc Physicians India 2012 Apr;60:60-1. PMID: 23029746
Asthma in pregnancy.
Tan KS, Thomson NC
Am J Med 2000 Dec 15;109(9):727-33. doi: 10.1016/s0002-9343(00)00615-x. PMID: 11137489

Clinical prediction guides

Post-Menopausal Bleeding: Role of Imaging.
Hurtado S, Shetty MK
Semin Ultrasound CT MR 2023 Dec;44(6):519-527. Epub 2023 Oct 11 doi: 10.1053/j.sult.2023.10.003. PMID: 37832697
Obesity and risk of female reproductive conditions: A Mendelian randomisation study.
Venkatesh SS, Ferreira T, Benonisdottir S, Rahmioglu N, Becker CM, Granne I, Zondervan KT, Holmes MV, Lindgren CM, Wittemans LBL
PLoS Med 2022 Feb;19(2):e1003679. Epub 2022 Feb 1 doi: 10.1371/journal.pmed.1003679. PMID: 35104295Free PMC Article
Approach to Abnormal Uterine Bleeding in Adolescents.
Yaşa C, Güngör Uğurlucan F
J Clin Res Pediatr Endocrinol 2020 Feb 6;12(Suppl 1):1-6. doi: 10.4274/jcrpe.galenos.2019.2019.S0200. PMID: 32041387Free PMC Article
Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.
Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN, Wentzensen N
JAMA Intern Med 2018 Sep 1;178(9):1210-1222. doi: 10.1001/jamainternmed.2018.2820. PMID: 30083701Free PMC Article
Peripartum hemorrhage.
Alamia V Jr, Meyer BA
Obstet Gynecol Clin North Am 1999 Jun;26(2):385-98. doi: 10.1016/s0889-8545(05)70081-4. PMID: 10399768

Recent systematic reviews

Efficacy and safety of fezolinetant, a neurokinin-3 antagonist, in treating vasomotor symptoms in postmenopausal women: A systematic review and meta-analysis.
Rahman UA, Kashif TB, Usman M, Rana M, Hasanain M, Anjum MU, Cheema HA, Jaffar H, Bhattarai P
Medicine (Baltimore) 2023 Dec 15;102(50):e36592. doi: 10.1097/MD.0000000000036592. PMID: 38115258Free PMC Article
Cesarean scar defects and abnormal uterine bleeding: a systematic review and meta-analysis.
Murji A, Sanders AP, Monteiro I, Haiderbhai S, Matelski J, Walsh C, Abbott JA, Munro MG, Maheux-Lacroix S; International Federation of Gynecology and Obstetrics (FIGO) Committee on Menstrual Disorders and Related Health Impacts
Fertil Steril 2022 Oct;118(4):758-766. Epub 2022 Aug 17 doi: 10.1016/j.fertnstert.2022.06.031. PMID: 35985862
Prevalence of hyperplasia and cancer in endometrial polyps in women with postmenopausal bleeding: A systematic review and meta-analysis.
Ghoubara A, Price MJ, Fahmy MSE, Ait-Allah AS, Ewies A
Post Reprod Health 2019 Jun;25(2):86-94. Epub 2019 Mar 7 doi: 10.1177/2053369119833583. PMID: 30845879
Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.
Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN, Wentzensen N
JAMA Intern Med 2018 Sep 1;178(9):1210-1222. doi: 10.1001/jamainternmed.2018.2820. PMID: 30083701Free PMC Article
Position in the second stage of labour for women without epidural anaesthesia.
Gupta JK, Sood A, Hofmeyr GJ, Vogel JP
Cochrane Database Syst Rev 2017 May 25;5(5):CD002006. doi: 10.1002/14651858.CD002006.pub4. PMID: 28539008Free PMC Article

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