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Ventricular Outflow Obstruction

MedGen UID:: 52999
•Concept ID:: C0042512
•: Disease or Syndrome

Synonyms:

Obstruction, Ventricular Outflow; Outflow Obstruction, Ventricular; Ventricular Outflow Obstructions

Definition

Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVentricular Outflow Obstruction

Professional guidelines

PubMed

The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: Management of infants and neonates with tetralogy of Fallot.

Expert Consensus Panel:, Miller JR, Stephens EH, Goldstone AB, Glatz AC, Kane L, Van Arsdell GS, Stellin G, Barron DJ, d'Udekem Y, Benson L, Quintessenza J, Ohye RG, Talwar S, Fremes SE, Emani SM, Eghtesady P
J Thorac Cardiovasc Surg 2023 Jan;165(1):221-250. Epub 2022 Oct 26 doi: 10.1016/j.jtcvs.2022.07.025. PMID: 36522807

Canadian Cardiovascular Society 2022 Guidelines for Cardiovascular Interventions in Adults With Congenital Heart Disease.

Marelli A, Beauchesne L, Colman J, Ducas R, Grewal J, Keir M, Khairy P, Oechslin E, Therrien J, Vonder Muhll IF, Wald RM, Silversides C, Barron DJ, Benson L, Bernier PL, Horlick E, Ibrahim R, Martucci G, Nair K, Poirier NC, Ross HJ, Baumgartner H, Daniels CJ, Gurvitz M, Roos-Hesselink JW, Kovacs AH, McLeod CJ, Mulder BJ, Warnes CA, Webb GD
Can J Cardiol 2022 Jul;38(7):862-896. Epub 2022 Apr 20 doi: 10.1016/j.cjca.2022.03.021. PMID: 35460862

The role of imaging in the diagnosis and management of hypertrophic cardiomyopathy.

Weissler-Snir A, Crean A, Rakowski H
Expert Rev Cardiovasc Ther 2016;14(1):51-74. Epub 2015 Nov 14 doi: 10.1586/14779072.2016.1113130. PMID: 26567960

See all (34)

Recent clinical studies

Etiology

Transcatheter Myotomy for Hypertrophic Obstructive Cardiomyopathy.

Danek B, Elison D, Chung CJ, McCabe JM
Curr Cardiol Rep 2024 Dec;26(12):1471-1476. Epub 2024 Oct 19 doi: 10.1007/s11886-024-02145-z. PMID: 39425812

Obstruction in Hypertrophic Cardiomyopathy: Many Faces.

Abbasi M, Ong KC, Newman DB, Dearani JA, Schaff HV, Geske JB
J Am Soc Echocardiogr 2024 Jun;37(6):613-625. Epub 2024 Feb 28 doi: 10.1016/j.echo.2024.02.010. PMID: 38428652

Progressive Hypertension and Severe Left Ventricular Outflow Tract Obstruction.

Cameron AC, Lang NN, Dominiczak AF, Jennings GLR, Batlle D, Bursztyn M, Chugh AR, Floras JS, Taler SJ, Touyz RM, Delles C
Hypertension 2019 Dec;74(6):1216-1225. Epub 2019 Oct 7 doi: 10.1161/HYPERTENSIONAHA.119.13343. PMID: 31587571

Cardiovascular disease in Williams syndrome.

Collins RT 2nd
Curr Opin Pediatr 2018 Oct;30(5):609-615. doi: 10.1097/MOP.0000000000000664. PMID: 30045083

Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction: Expecting the Unexpected.

Jain P, Patel PA, Fabbro M 2nd
J Cardiothorac Vasc Anesth 2018 Feb;32(1):467-477. Epub 2017 May 1 doi: 10.1053/j.jvca.2017.04.054. PMID: 28967624

See all (1709)

Diagnosis

Progressive Hypertension and Severe Left Ventricular Outflow Tract Obstruction.

Brokenbrough-Braunwald-Morrow Sign.

Anderson RD, Grigg L
Heart Lung Circ 2018 Jun;27(6):e78-e81. Epub 2017 Feb 16 doi: 10.1016/j.hlc.2016.12.016. PMID: 29429587

Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction: Expecting the Unexpected.

Jain P, Patel PA, Fabbro M 2nd
J Cardiothorac Vasc Anesth 2018 Feb;32(1):467-477. Epub 2017 May 1 doi: 10.1053/j.jvca.2017.04.054. PMID: 28967624

Brockenbrough-Braunwald-Morrow sign.

Sim MM
Eur Heart J 2017 Mar 21;38(12):868. doi: 10.1093/eurheartj/ehw512. PMID: 28329130

Left ventricular outflow obstruction.

Arnold R, Kitchiner D
Arch Dis Child 1995 Feb;72(2):180-3. doi: 10.1136/adc.72.2.180. PMID: 7702390 Free PMC Article

See all (1710)

Therapy

Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Maron MS, Masri A, Nassif ME, Barriales-Villa R, Arad M, Cardim N, Choudhury L, Claggett B, Coats CJ, Düngen HD, Garcia-Pavia P, Hagège AA, Januzzi JL, Lee MMY, Lewis GD, Ma CS, Michels M, Olivotto I, Oreziak A, Owens AT, Spertus JA, Solomon SD, Tfelt-Hansen J, van Sinttruije M, Veselka J, Watkins H, Jacoby DL, Heitner SB, Kupfer S, Malik FI, Meng L, Wohltman A, Abraham TP; SEQUOIA-HCM Investigators
N Engl J Med 2024 May 30;390(20):1849-1861. Epub 2024 May 13 doi: 10.1056/NEJMoa2401424. PMID: 38739079

Septal Bipolar Ablation to Prevent Left Ventricular Outflow Tract Obstruction After Transcatheter Mitral Valve Implantation.

Hoskins MH, Lisko JC, Greenbaum AB, Ueyama HA, Merchant FM, Lloyd MS, Gleason PT, El-Chami MF, Byku I, Block PC, Lederman RJ, Babaliaros VC, Westerman SB
Circ Cardiovasc Interv 2023 Oct;16(10):e013333. Epub 2023 Sep 15 doi: 10.1161/CIRCINTERVENTIONS.123.013333. PMID: 37712286 Free PMC Article

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy.

Dybro AM, Rasmussen TB, Nielsen RR, Andersen MJ, Jensen MK, Poulsen SH
J Am Coll Cardiol 2021 Dec 21;78(25):2505-2517. doi: 10.1016/j.jacc.2021.07.065. PMID: 34915981

Transcatheter Mitral Valve Replacement with Tendyne.

Niikura H, Gössl M, Sorajja P
Interv Cardiol Clin 2019 Jul;8(3):295-300. Epub 2019 Apr 6 doi: 10.1016/j.iccl.2019.02.003. PMID: 31078185

Left Ventricular Outflow Tract Obstruction: Coarctation of the Aorta, Interrupted Aortic Arch, and Borderline Left Ventricle.

Kaza AK, Thiagarajan RR
Pediatr Crit Care Med 2016 Aug;17(8 Suppl 1):S315-7. doi: 10.1097/PCC.0000000000000826. PMID: 27490616

See all (1052)

Prognosis

Evolution of residual and recurrent right ventricular outflow tract obstruction after tetralogy of Fallot repair.

Tan C, Soquet J, Brizard CP, d'Udekem Y
J Thorac Cardiovasc Surg 2020 Apr;159(4):e275-e277. Epub 2019 Nov 5 doi: 10.1016/j.jtcvs.2019.09.190. PMID: 31839225

Progressive Hypertension and Severe Left Ventricular Outflow Tract Obstruction.

Surgical management of transposition with ventricular septal defect and obstruction to the left ventricular outflow tract.

Morell VO, Jacobs JP, Quintessenza JA
Cardiol Young 2005 Feb;15 Suppl 1:102-5. doi: 10.1017/s1047951105001113. PMID: 15934700

Open-heart surgery in pediatric patients with end-stage liver disease.

Bacha EA, Hardin J, Cronin DC, Brady L, Millis MJ, Starr JP, Koenig P, Daves S, Kahana M
Ann Thorac Surg 2004 Aug;78(2):e30-3. doi: 10.1016/j.athoracsur.2003.11.043. PMID: 15276586

How to construct a monocusp valve.

Gundry SR
Adv Card Surg 2000;12:169-74. PMID: 10949649

See all (1256)

Clinical prediction guides

Comparison of Predicted and Confirmed Neo-Left Ventricular Outflow Tract After Transcatheter Mitral Valve Replacement.

Puehler T, Blanke P, Seoudy H, Sathananthan J, Sellers SL, Meier D, Both M, Saad M, Frank D, Søndergaard L, Lutter G
JACC Cardiovasc Interv 2022 Oct 24;15(20):e219-e221. Epub 2022 Sep 28 doi: 10.1016/j.jcin.2022.07.032. PMID: 36265952

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy.

Dybro AM, Rasmussen TB, Nielsen RR, Andersen MJ, Jensen MK, Poulsen SH
J Am Coll Cardiol 2021 Dec 21;78(25):2505-2517. doi: 10.1016/j.jacc.2021.07.065. PMID: 34915981

Double-chambered right ventricle: a review.

Loukas M, Housman B, Blaak C, Kralovic S, Tubbs RS, Anderson RH
Cardiovasc Pathol 2013 Nov-Dec;22(6):417-23. Epub 2013 May 20 doi: 10.1016/j.carpath.2013.03.004. PMID: 23701985

Risk stratification in hypertrophic cardiomyopathy: time for renewal?

Pacileo G, Salerno G, Gravino R, Calabrò R, Elliott PM
J Cardiovasc Med (Hagerstown) 2013 May;14(5):319-25. doi: 10.2459/JCM.0b013e328357739e. PMID: 22885536

The role of echocardiography in mitral valve dysfunction after repair.

Quigley RL
Minerva Cardioangiol 2007 Apr;55(2):239-46. PMID: 17342041

See all (739)

Recent systematic reviews

Right ventricular outflow tract obstruction in twin-to-twin transfusion syndrome undergoing laser surgery: A systematic review and meta-analysis.

Mustafa HJ, Jawwad M, Iqbal Mansoor A, Pagani G, D'Antonio F, Khalil A
Acta Obstet Gynecol Scand 2024 Aug;103(8):1513-1521. Epub 2024 Mar 14 doi: 10.1111/aogs.14825. PMID: 38482999 Free PMC Article

Absent pulmonary valve with tricuspid atresia/stenosis: literature review with new three long-term cases.

Kawasaki Y, Murakami Y, Fujino M, Sasaki T, Nakamura K, Yoshida Y, Suzuki T, Nishigaki K, Ehara E
Heart Vessels 2022 Jan;37(1):142-151. Epub 2021 Jun 5 doi: 10.1007/s00380-021-01887-y. PMID: 34089363

Right ventricular outflow tract reconstruction with Medtronic Freestyle valve in the Ross procedure: A systematic review with meta-analysis.

Van den Eynde J, Sá MPBO, Callahan CP, Dimagli A, Vervoort D, Kampaktsis PN, Zhigalov K, Ruhparwar A, Weymann A
Artif Organs 2021 Apr;45(4):338-345. Epub 2020 Nov 18 doi: 10.1111/aor.13837. PMID: 33001477

Outcomes following the surgical management of left ventricular outflow tract obstruction; A systematic review and meta-analysis.

Collis RA, Rahman MS, Watkinson O, Guttmann OP, O'Mahony C, Elliott PM
Int J Cardiol 2018 Aug 15;265:62-70. doi: 10.1016/j.ijcard.2018.01.130. PMID: 29885701

Left ventricular aneurysms in hypertrophic cardiomyopathy with midventricular obstruction: A systematic review of literature.

Elsheshtawy MO, Mahmoud AN, Abdelghany M, Suen IH, Sadiq A, Shani J
Pacing Clin Electrophysiol 2018 Jul;41(7):854-865. Epub 2018 Jun 20 doi: 10.1111/pace.13380. PMID: 29786883

See all (16)

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Ventricular Outflow Obstruction

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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