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Neonatal toxic erythema

MedGen UID:
537820
•Concept ID:
C0263324
•
Disease or Syndrome
Synonyms: Erythema neonatorum; Erythema Toxicum Neonatorum; Erythema toxicum neonatorum; ETN - erythema toxicum neonatorum; Neonatal erythema toxicum; Toxic erythema of newborn
SNOMED CT: Neonatal toxic erythema (1162449005); Erythema toxicum neonatorum (1162449005); Erythema neonatorum (1162449005); ETN - erythema toxicum neonatorum (1162449005); Neonatal erythema toxicum (1162449005); Toxic erythema of newborn (1162449005)

Definition

A benign, self-limited eruption of vesicles, pustules, papules and macules seen in newborns. An eosinophilic infiltrate can be isolated suggesting an immune-mediated reaction in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal toxic erythema

Professional guidelines

PubMed

Association of HLA genotypes with phenytoin induced severe cutaneous adverse drug reactions in Thai children.
Manuyakorn W, Likkasittipan P, Wattanapokayakit S, Suvichapanich S, Inunchot W, Wichukchinda N, Khongkhatithuml C, Thampratankul L, Kamchaisatian W, Benjaponpitak S, Mahasirimongkol S
Epilepsy Res 2020 May;162:106321. Epub 2020 Mar 13 doi: 10.1016/j.eplepsyres.2020.106321. PMID: 32272329
Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management.
Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM
Cornea 2007 Feb;26(2):123-9. doi: 10.1097/ICO.0b013e31802eb264. PMID: 17251797
Scalded skin syndrome: Diagnosis, differential diagnosis, and management of 42 children.
Margileth AM
South Med J 1975 Apr;68(4):447-54. PMID: 123658

Recent clinical studies

Etiology

Infantile Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review of clinical features and outcomes in children ages 12 months and under.
Iriarte C, Karim SA, Nassim JS, Grenier PO, Massey KJ
Pediatr Dermatol 2022 Nov;39(6):876-882. Epub 2022 Jun 8 doi: 10.1111/pde.15047. PMID: 35676891
Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.
Arantes LB, Reis CS, Novaes AG, Carvalho MR, Göttems LBD, Novaes MRCG
An Bras Dermatol 2017 Sep-Oct;92(5):661-667. doi: 10.1590/abd1806-4841.20176610. PMID: 29166503Free PMC Article
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Toxic epidermal necrolysis.
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Coccidioidomycosis and pregnancy.
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516

Diagnosis

Neonatal Toxic Shock Syndrome-Like Exanthematous Disease in North America.
Freeman MC, Mitchell S, Ibrahim J, Williams JV
J Pediatric Infect Dis Soc 2021 Mar 26;10(2):205-206. doi: 10.1093/jpids/piz060. PMID: 31550351
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Guide for Nurses.
Hanson LM, Bettencourt AP
AACN Adv Crit Care 2020 Sep 15;31(3):281-295. doi: 10.4037/aacnacc2020634. PMID: 32866260Free PMC Article
Toxic epidermal necrolysis.
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Coccidioidomycosis and pregnancy.
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516
Neonatal skin disorders.
Mallory SB
Pediatr Clin North Am 1991 Aug;38(4):745-61. doi: 10.1016/s0031-3955(16)38152-4. PMID: 1870904

Therapy

Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Toxic epidermal necrolysis.
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Coccidioidomycosis and pregnancy.
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516
Vancomycin: an update.
Cheung RP, DiPiro JT
Pharmacotherapy 1986 Jul-Aug;6(4):153-69. doi: 10.1002/j.1875-9114.1986.tb03471.x. PMID: 3534799
Boric acid toxicity.
Siegel E, Wason S
Pediatr Clin North Am 1986 Apr;33(2):363-7. doi: 10.1016/s0031-3955(16)35006-4. PMID: 2870462

Prognosis

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Guide for Nurses.
Hanson LM, Bettencourt AP
AACN Adv Crit Care 2020 Sep 15;31(3):281-295. doi: 10.4037/aacnacc2020634. PMID: 32866260Free PMC Article
Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI
J Am Acad Dermatol 2017 May;76(5):811-817.e4. Epub 2017 Mar 9 doi: 10.1016/j.jaad.2016.12.024. PMID: 28285784Free PMC Article
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Toxic epidermal necrolysis in a neonate receiving fluconazole.
Islam S, Singer M, Kulhanjian JA
J Perinatol 2014 Oct;34(10):792-4. doi: 10.1038/jp.2014.92. PMID: 25263725
Toxic epidermal necrolysis.
Greer KE
Cutis 1979 Nov;24(5):565-8. PMID: 520035

Clinical prediction guides

Predictors of 30-day readmission in Stevens-Johnson syndrome and toxic epidermal necrolysis: A cross-sectional database study.
Guzman AK, Zhang M, Kwatra SG, Kaffenberger BH
J Am Acad Dermatol 2020 Feb;82(2):303-310. Epub 2019 Sep 19 doi: 10.1016/j.jaad.2019.09.017. PMID: 31542405
Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI
J Am Acad Dermatol 2017 May;76(5):811-817.e4. Epub 2017 Mar 9 doi: 10.1016/j.jaad.2016.12.024. PMID: 28285784Free PMC Article
Nationwide Survey of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children in the United States.
Okubo Y, Nochioka K, Testa MA
Pediatr Dermatol 2017 Mar;34(2):206-208. Epub 2016 Dec 19 doi: 10.1111/pde.13050. PMID: 27990674
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Staphylococcal cutaneous infections: invasion, evasion and aggression.
Iwatsuki K, Yamasaki O, Morizane S, Oono T
J Dermatol Sci 2006 Jun;42(3):203-14. Epub 2006 May 6 doi: 10.1016/j.jdermsci.2006.03.011. PMID: 16679003

Recent systematic reviews

Algorithm to attenuate atopic dermatitis and for promoting a healthy skin barrier using skincare in newborns and infants.
Schachner LA, Blume-Peytavi U, Andriessen A, Izakovic J, Maruani A, Micali G, Murashkin N, Salavastru C, Torrelo A
Ital J Dermatol Venerol 2023 Jun;158(3):224-235. doi: 10.23736/S2784-8671.23.07336-X. PMID: 37278500
Infantile Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review of clinical features and outcomes in children ages 12 months and under.
Iriarte C, Karim SA, Nassim JS, Grenier PO, Massey KJ
Pediatr Dermatol 2022 Nov;39(6):876-882. Epub 2022 Jun 8 doi: 10.1111/pde.15047. PMID: 35676891
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

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