U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cleft upper lip, upper jaw AND palate

MedGen UID:
539673
•Concept ID:
C0266090
•
Congenital Abnormality
Synonyms: Cheilognathopalatoschisis; Cheilognathouranoschisis
SNOMED CT: Cheilognathopalatoschisis (337471007); Cleft upper lip, upper jaw AND palate (337471007); Cheilognathouranoschisis (338486003)

Definition

A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCleft upper lip, upper jaw AND palate

Professional guidelines

PubMed

STUDY OF THE STRESS-STRAIN STATE OF THE MAXILLA DURING ORTHODONTIC TREATMENT OF DENTOGNATHIC DEFORMATIONS IN CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE.
Filonenko VV, Kaniura OА, Kopchak AV, Kryshchuk MG
Wiad Lek 2023;76(12):2648-2656. doi: 10.36740/WLek202312114. PMID: 38290029
Presurgical orthopedic treatment for cleft lip and palate.
Papay FA, Morales L, Yamashiro D
Facial Plast Surg 1993 Jan;9(1):74-7. doi: 10.1055/s-2008-1064598. PMID: 8472972
Team work and clinical research in the treatment of cleft lip and palate.
Hellquist R
Sven Tandlak Tidskr 1973 Mar;66(2):145-55. PMID: 4575494

Recent clinical studies

Etiology

Helical distraction is superior to linear distraction in maxillary distraction osteogenesis: an in silico study.
Gateno J, Kim D, Bartlett S, Gonzalez C, Xu J, Xia JJ
Int J Oral Maxillofac Surg 2023 Sep;52(9):971-980. Epub 2023 Feb 20 doi: 10.1016/j.ijom.2023.01.020. PMID: 36813600
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Effect of timing and method of cleft palate repair on dental arches at the age of three years.
Nyström M, Ranta R
Cleft Palate J 1990 Oct;27(4):349-52; discussion 352-3. doi: 10.1597/1545-1569(1990)027<0349:eotamo>2.3.co;2. PMID: 2253380
Treatment of severe unilateral open bite and crossbite in cleft lip and palate patients.
Enemark H
Eur J Orthod 1984 Nov;6(4):294-302. doi: 10.1093/ejo/6.4.294. PMID: 6391942
Team work and clinical research in the treatment of cleft lip and palate.
Hellquist R
Sven Tandlak Tidskr 1973 Mar;66(2):145-55. PMID: 4575494

Diagnosis

Segmental maxillary osteotomy in cleft lip and palate patients: a stepwise planning in the orthodontic pre-surgical preparation with Invisalign.
Meazzini MC, Demonte LP, Autelitano L
Eur J Paediatr Dent 2024 Sep 3;25(3):224-229. Epub 2024 Jul 1 doi: 10.23804/ejpd.2024.2112. PMID: 39069952
Understanding the distinction between cleft lip and cleft palate: a critical step for successful prenatal detection.
Minor K, Chueh J
Curr Opin Obstet Gynecol 2023 Apr 1;35(2):113-126. Epub 2023 Jan 24 doi: 10.1097/GCO.0000000000000852. PMID: 36912278
Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.
Jaruga A, Ksiazkiewicz J, Kuzniarz K, Tylzanowski P
Int J Mol Sci 2022 Jan 16;23(2) doi: 10.3390/ijms23020953. PMID: 35055138Free PMC Article
Malformations of the zygomatic and maxillary regions.
Xu C, Zhang Y, Yang Y, Liang Y
J Craniofac Surg 2013 Jul;24(4):1465-9. doi: 10.1097/SCS.0b013e3182902eaf. PMID: 23851833
Cleft lip and palate with associated digital and cardiac anomalies: a new dominant orofacial clefting syndrome?
McWilliam CA, Devlin MF, Joss SK, Koppel DA, Longman C, Ray A, Whiteford ML
Clin Dysmorphol 2011 Apr;20(2):89-91. doi: 10.1097/MCD.0b013e3283428f60. PMID: 21178587

Therapy

Dentofacial Orthopedics for the Cleft Patient: The Latham Approach.
Allareddy V, Shusterman S, Ross E, Palermo V, Ricalde P
Oral Maxillofac Surg Clin North Am 2020 May;32(2):187-196. Epub 2020 Feb 17 doi: 10.1016/j.coms.2020.01.002. PMID: 32081579
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Mucosal Dehiscence After Alveolar Bone Graft in Cleft.
Amodeo G, Scopelliti D
J Craniofac Surg 2018 Mar;29(2):e126-e128. doi: 10.1097/SCS.0000000000004135. PMID: 29215438
Influence of pharyngeal flap surgery on maxillary outgrowth in cleft patients.
Voshol IE, van Adrichem LN, van der Wal KG, Koudstaal MJ
Int J Oral Maxillofac Surg 2013 Feb;42(2):192-7. Epub 2012 Nov 2 doi: 10.1016/j.ijom.2012.09.022. PMID: 23123098
A new protocol for maxillary protraction in cleft patients: repetitive weekly protocol of alternate rapid maxillary expansions and constrictions.
Liou EJ, Tsai WC
Cleft Palate Craniofac J 2005 Mar;42(2):121-7. doi: 10.1597/03-107.1. PMID: 15748102

Prognosis

Cleft Lip and Palate: LeFort I Distraction with Halo and Hybrid Internal Maxillary Distractors.
Figueroa AA, Figueroa AD, Burton RG, Tragos C
Clin Plast Surg 2021 Jul;48(3):391-405. Epub 2021 May 8 doi: 10.1016/j.cps.2021.02.002. PMID: 34051893
Treatment of midfacial hypoplasia in syndromic and cleft lip and palate patients by means of a rigid external distractor (RED).
Sant'Anna EF, Cury-Saramago Ade A, Lau GW, Polley JW, Figueroa ÁA
Dental Press J Orthod 2013 Jul-Aug;18(4):134-43. doi: 10.1590/s2176-94512013000400005. PMID: 24262427
Nonorthodontic orthognathic surgery.
Schleich AR, Eppley BL
J Craniofac Surg 2009 Sep;20(5):1478-83. doi: 10.1097/SCS.0b013e3181b09a49. PMID: 19816282
Team work and clinical research in the treatment of cleft lip and palate.
Hellquist R
Sven Tandlak Tidskr 1973 Mar;66(2):145-55. PMID: 4575494
Longitudinal study of growth in bilateral cleft lip and palate, from infancy to adolescence.
Friede H, Pruzansky S
Plast Reconstr Surg 1972 Apr;49(4):392-403. doi: 10.1097/00006534-197204000-00005. PMID: 5014698

Clinical prediction guides

Cleft Lip and Palate: LeFort I Distraction with Halo and Hybrid Internal Maxillary Distractors.
Figueroa AA, Figueroa AD, Burton RG, Tragos C
Clin Plast Surg 2021 Jul;48(3):391-405. Epub 2021 May 8 doi: 10.1016/j.cps.2021.02.002. PMID: 34051893
Treatment of midfacial hypoplasia in syndromic and cleft lip and palate patients by means of a rigid external distractor (RED).
Sant'Anna EF, Cury-Saramago Ade A, Lau GW, Polley JW, Figueroa ÁA
Dental Press J Orthod 2013 Jul-Aug;18(4):134-43. doi: 10.1590/s2176-94512013000400005. PMID: 24262427
The normal-equivalent: a patient-specific assessment of facial harmony.
Claes P, Walters M, Gillett D, Vandermeulen D, Clement JG, Suetens P
Int J Oral Maxillofac Surg 2013 Sep;42(9):1150-8. Epub 2013 Apr 11 doi: 10.1016/j.ijom.2013.03.011. PMID: 23582569
Growth and development in patients with untreated clefts.
Will LA
Cleft Palate Craniofac J 2000 Nov;37(6):523-6. doi: 10.1597/1545-1569_2000_037_0523_gadipw_2.0.co_2. PMID: 11108517
Early prediction of the need for orthognathic surgery in cleft lip and palate patients.
Valley MA, Rosenstein SW, Lautenschlager EP, O'Gara MM
Northwest Dent Res 1995 Fall;6(1):24-8. PMID: 9487916

Recent systematic reviews

Rapid maxillary expansion vs slow maxillary expansion in patients with cleft lip and/or palate: a systematic review and meta-analysis.
Luyten J, De Roo NMC, Christiaens J, Van Overberghe L, Temmerman L, De Pauw GAM
Angle Orthod 2023 Jan 1;93(1):95-103. doi: 10.2319/030122-188.1. PMID: 36240430Free PMC Article
Relapse-related factors of Le Fort I osteotomy in cleft lip and palate patients: A systematic review and meta-analysis.
Valls-Ontañón A, Fernandes-Ciaccia L, Haas-Junior OL, Hernández-Alfaro F
J Craniomaxillofac Surg 2021 Oct;49(10):879-890. Epub 2021 Sep 10 doi: 10.1016/j.jcms.2021.09.002. PMID: 34538538
What is the relapse after Le Fort I maxillary advancement in cleft lip and palate patients? A systematic review.
Velasques BD, Moura LB, Martins JR, Damian MF, Xavier CB
Oral Maxillofac Surg 2021 Jun;25(2):139-148. Epub 2020 Sep 17 doi: 10.1007/s10006-020-00906-y. PMID: 32940776
Maxillofacial growth and speech outcome after one-stage or two-stage palatoplasty in unilateral cleft lip and palate. A systematic review.
Reddy RR, Gosla Reddy S, Vaidhyanathan A, Bergé SJ, Kuijpers-Jagtman AM
J Craniomaxillofac Surg 2017 Jun;45(6):995-1003. Epub 2017 Mar 22 doi: 10.1016/j.jcms.2017.03.006. PMID: 28427835
Hard palate-repair technique and facial growth in patients with cleft lip and palate: a systematic review.
Lee YH, Liao YF
Br J Oral Maxillofac Surg 2013 Dec;51(8):851-7. Epub 2013 Sep 14 doi: 10.1016/j.bjoms.2013.08.012. PMID: 24045106

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...