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Malignant neoplasm of endocervix

MedGen UID:
56309
•Concept ID:
C0153569
•
Neoplastic Process
Synonyms: Cancer of endocervix; cancer of endocervix; endocervix cancer; Malignant Endocervical Neoplasm; malignant endocervical neoplasm; Malignant Endocervical Tumor; malignant endocervical tumor; malignant endocervical tumour; Malignant Endocervix Neoplasm; malignant endocervix neoplasm; Malignant Endocervix Tumor; malignant endocervix tumor; malignant endocervix tumour; Malignant neoplasm of endocervical canal; Malignant Neoplasm of Endocervix; malignant neoplasm of endocervix; Malignant Neoplasm of the Endocervix; malignant neoplasm of the endocervix; Malignant Neoplasm of the Uterine Endocervix; malignant neoplasm of the uterine endocervix; Malignant Neoplasm of Uterine Endocervix; malignant neoplasm of uterine endocervix; Malignant Tumor of Endocervix; malignant tumor of endocervix; Malignant Tumor of the Endocervix; malignant tumor of the endocervix; Malignant Tumor of the Uterine Endocervix; malignant tumor of the uterine endocervix; Malignant Tumor of Uterine Endocervix; malignant tumor of uterine endocervix; malignant tumour of endocervix; malignant tumour of the endocervix; malignant tumour of the uterine endocervix; malignant tumour of uterine endocervix; Malignant Uterine Endocervix Neoplasm; malignant uterine endocervix neoplasm; Malignant Uterine Endocervix Tumor; malignant uterine endocervix tumor; malignant uterine endocervix tumour
SNOMED CT: Malignant neoplasm of endocervix (372097009); Malignant neoplasm of endocervical canal (188176007); Cancer of endocervix (372097009)
 
Monarch Initiative: MONDO:0021309

Definition

A malignant neoplasm that affects the endocervix. [from NCI]

Professional guidelines

PubMed

Global challenges of radiotherapy for the treatment of locally advanced cervical cancer.
Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R, Toita T
Int J Gynecol Cancer 2022 Mar;32(3):436-445. doi: 10.1136/ijgc-2021-003001. PMID: 35256434Free PMC Article
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer.
Lim K, Small W Jr, Portelance L, Creutzberg C, Jürgenliemk-Schulz IM, Mundt A, Mell LK, Mayr N, Viswanathan A, Jhingran A, Erickson B, De los Santos J, Gaffney D, Yashar C, Beriwal S, Wolfson A, Taylor A, Bosch W, El Naqa I, Fyles A; Gyn IMRT Consortium
Int J Radiat Oncol Biol Phys 2011 Feb 1;79(2):348-55. Epub 2010 May 14 doi: 10.1016/j.ijrobp.2009.10.075. PMID: 20472347

Recent clinical studies

Etiology

Advanced stage (FIGO IVB) neuroendocrine cervical carcinoma.
Salvo G, Ramalingam P, Bhosale P, Frumovitz M
Int J Gynecol Cancer 2022 Nov 7;32(11):1469-1474. doi: 10.1136/ijgc-2022-003946. PMID: 36343974Free PMC Article
Diffusion-Tensor Imaging of Uterine Cervical Carcinoma: Correlation With Histopathologic Findings.
Yamada I, Oshima N, Wakabayashi A, Miyasaka N, Wakana K, Saida Y, Tateishi U, Kobayashi D
J Comput Assist Tomogr 2020 May/Jun;44(3):426-435. doi: 10.1097/RCT.0000000000001014. PMID: 32345807
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
LLETZ and infertility.
Kennedy S, Robinson J, Hallam N
Br J Obstet Gynaecol 1993 Oct;100(10):965. doi: 10.1111/j.1471-0528.1993.tb15123.x. PMID: 8217988
The prevention of cervical cancer: the place of the cytological smear test.
Hudson E
Clin Obstet Gynaecol 1985 Mar;12(1):33-51. PMID: 3888487

Diagnosis

Interpretation pitfalls and malignant mimics in cervical cytology.
Torous VF, Pitman MB
J Am Soc Cytopathol 2021 Mar-Apr;10(2):115-127. Epub 2020 Jun 25 doi: 10.1016/j.jasc.2020.06.005. PMID: 32732114
Primary malignant melanoma of uterine cervix.
DI Meo N, Conforti C, Nan K, Romano A, Degrassi F, Cova MA, Ukmar M, Zalaudek I
Ital J Dermatol Venerol 2021 Dec;156(Suppl. 1 to No. 6):110-111. Epub 2020 Mar 4 doi: 10.23736/S2784-8671.19.06512-X. PMID: 32129585
Cervicovaginal cellular angiofibroma.
Van Mulders S, Faes E, Broeckx G, Jacquemyn Y
BMJ Case Rep 2020 Jul 16;13(7) doi: 10.1136/bcr-2020-235241. PMID: 32675122Free PMC Article
Early diagnosis of cancer of the cervix uteri.
DONALDSON M
Br Med J 1955 Oct 29;2(4947):1081-3. doi: 10.1136/bmj.2.4947.1081. PMID: 13260668Free PMC Article
Early diagnosis of cancer of the cervix.
ANTOINE T
Am J Obstet Gynecol 1954 Jul;68(1):466-73. doi: 10.1016/0002-9378(54)90506-2. PMID: 13171452

Therapy

Artificial intelligence enables precision diagnosis of cervical cytology grades and cervical cancer.
Wang J, Yu Y, Tan Y, Wan H, Zheng N, He Z, Mao L, Ren W, Chen K, Lin Z, He G, Chen Y, Chen R, Xu H, Liu K, Yao Q, Fu S, Song Y, Chen Q, Zuo L, Wei L, Wang J, Ouyang N, Yao H
Nat Commun 2024 May 22;15(1):4369. doi: 10.1038/s41467-024-48705-3. PMID: 38778014Free PMC Article
Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Classification of radical hysterectomy.
Querleu D, Morrow CP
Lancet Oncol 2008 Mar;9(3):297-303. doi: 10.1016/S1470-2045(08)70074-3. PMID: 18308255

Prognosis

Implications of the new FIGO staging and the role of imaging in cervical cancer.
Kido A, Nakamoto Y
Br J Radiol 2021 Sep 1;94(1125):20201342. Epub 2021 May 14 doi: 10.1259/bjr.20201342. PMID: 33989030Free PMC Article
Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial.
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
The prevention of cervical cancer: the place of the cytological smear test.
Hudson E
Clin Obstet Gynaecol 1985 Mar;12(1):33-51. PMID: 3888487
Age, incidence, and distribution of 4,652 cases of carcinoma of the cervix with a report of three cases during the first two decades of life.
SADUGOR MG, PALMER JP
Am J Obstet Gynecol 1948 Oct;56(4):680-6. doi: 10.1016/0002-9378(48)90406-2. PMID: 18882819

Clinical prediction guides

Adequacy in Endocervical Curettage.
Alqabbani R, Chan J, Goldberg A
Am J Clin Pathol 2022 Sep 2;158(3):378-382. doi: 10.1093/ajcp/aqac058. PMID: 35568991
Implications of the new FIGO staging and the role of imaging in cervical cancer.
Kido A, Nakamoto Y
Br J Radiol 2021 Sep 1;94(1125):20201342. Epub 2021 May 14 doi: 10.1259/bjr.20201342. PMID: 33989030Free PMC Article
Pap cytopathology and the presence of high-risk human papillomavirus in SurePath liquid preservative and Digene cervical sampler specimens.
Kapala J, Jang D, Patel J, Biers K, Smieja M, Chernesky M
J Virol Methods 2007 Jun;142(1-2):223-5. Epub 2007 Feb 23 doi: 10.1016/j.jviromet.2007.01.028. PMID: 17320978
Low grade and ASCUS lesions of the cervix: diagnostic difficulties and reproducibility.
Raab SS
Ann Pathol 1999;19(5 Suppl):S87-9. PMID: 10599462
Lesion size and histology of atypical cervical transformation zone.
Shafi MI, Finn CB, Luesley DM, Jordan JA, Dunn J
Br J Obstet Gynaecol 1991 May;98(5):490-2. doi: 10.1111/j.1471-0528.1991.tb10349.x. PMID: 2059601

Recent systematic reviews

Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review.
Wirtz C, Mohamed Y, Engel D, Sidibe A, Holloway M, Bloem P, Kumar S, Brotherton J, Reis V, Morgan C
Vaccine 2022 Mar 31;40 Suppl 1:A116-A123. Epub 2021 Dec 1 doi: 10.1016/j.vaccine.2021.11.013. PMID: 34863615
A systematic review and meta-analysis of sarcopenia as a prognostic factor in gynecological malignancy.
Allanson ER, Peng Y, Choi A, Hayes S, Janda M, Obermair A
Int J Gynecol Cancer 2020 Nov;30(11):1791-1797. Epub 2020 Aug 2 doi: 10.1136/ijgc-2020-001678. PMID: 32747410
Patterns of incident genital human papillomavirus infection in women: A literature review and meta-analysis.
Wheeler BS, Rositch AF, Poole C, Taylor SM, Smith JS
Int J STD AIDS 2019 Nov;30(13):1246-1256. Epub 2019 Oct 22 doi: 10.1177/0956462418824441. PMID: 31640474
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article

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