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Benign conjunctival neoplasm

MedGen UID:
56328
•Concept ID:
C0154025
•
Neoplastic Process
Synonyms: Benign Conjunctiva Neoplasm; benign conjunctiva neoplasm; Benign Conjunctiva Tumor; benign conjunctiva tumor; benign conjunctiva tumour; Benign Conjunctival Neoplasm; benign conjunctival neoplasm; Benign Conjunctival Tumor; benign conjunctival tumor; benign conjunctival tumour; Benign neoplasm of conjunctiva; Benign Neoplasm of Conjunctiva; benign neoplasm of conjunctiva; Benign Neoplasm of the Conjunctiva; benign neoplasm of the conjunctiva; Benign tumor of conjunctiva; Benign Tumor of Conjunctiva; benign tumor of conjunctiva; Benign Tumor of the Conjunctiva; benign tumor of the conjunctiva; benign tumour of conjunctiva; benign tumour of the conjunctiva; conjunctiva benign neoplasm
SNOMED CT: Benign tumor of conjunctiva (92068002); Benign neoplasm of conjunctiva (92068002)
 
Monarch Initiative: MONDO:0006105

Definition

A neoplasm that arises from the conjunctiva and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Evaluation and management of benign tumors of the eye and eyelid.
Brown R, Fard S, Feng P, Kerr PE
Clin Dermatol 2024 Jul-Aug;42(4):343-350. Epub 2024 Jan 26 doi: 10.1016/j.clindermatol.2024.01.005. PMID: 38281689
Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Management of pigmented conjunctival lesions.
Oellers P, Karp CL
Ocul Surf 2012 Oct;10(4):251-63. Epub 2012 Aug 11 doi: 10.1016/j.jtos.2012.08.002. PMID: 23084146

Recent clinical studies

Etiology

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Ocular and Periocular Tumors in Asian Indian Children and Adolescents.
Kaliki S, Das AV
Indian Pediatr 2020 Jun 15;57(6):512-514. Epub 2020 Mar 12 PMID: 32221055
Spontaneous regression of a conjunctival naevus.
Haldar S, Leyland M
BMJ Case Rep 2016 Aug 31;2016 doi: 10.1136/bcr-2016-216066. PMID: 27581234Free PMC Article
Epibulbar schwannoma in a 12-year-old boy: A case report and review of literature.
Nair AG, Kaliki S, Mishra DK, Dave TV, Naik MN
Indian J Ophthalmol 2015 Jul;63(7):620-2. doi: 10.4103/0301-4738.167106. PMID: 26458484Free PMC Article

Diagnosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article
Benign fibrous histiocytoma.
Varma P, Walia S, Manglawat R
Indian J Ophthalmol 2014 Apr;62(4):464-7. doi: 10.4103/0301-4738.132104. PMID: 24817747Free PMC Article
Primary subconjunctival ganglioneuroma.
Kang SH, Kim KH
Ophthalmic Plast Reconstr Surg 2013 Mar-Apr;29(2):e36-7. doi: 10.1097/IOP.0b013e3182674052. PMID: 23034687

Therapy

Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article
Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition.
El Zaoui I, Bucher M, Rimoldi D, Nicolas M, Kaya G, Pescini Gobert R, Bedoni N, Schalenbourg A, Sakina E, Zografos L, Leyvraz S, Riggi N, Rivolta C, Moulin AP
Invest Ophthalmol Vis Sci 2019 Jun 3;60(7):2764-2772. doi: 10.1167/iovs.18-26508. PMID: 31247083
Can the onset of orbital cancer be the result of a prosthetic eye?
Croce A, Mastronardi V, Laus M, Festa Kotelnikova E
Acta Otorhinolaryngol Ital 2017 Dec;37(6):519-522. doi: 10.14639/0392-100X-1043. PMID: 28530256Free PMC Article
Pharmacotherapy and Immunotherapy of Conjunctival Tumors.
Midena E, Frizziero L, Parrozzani R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):121-131. doi: 10.22608/APO.201751. PMID: 28399343
Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.
Robinson JW, Brownstein S, Jordan DR, Hodge WG
Surv Ophthalmol 2006 Sep-Oct;51(5):513-9. doi: 10.1016/j.survophthal.2006.06.012. PMID: 16950250

Prognosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Epibulbar schwannoma in a 12-year-old boy: A case report and review of literature.
Nair AG, Kaliki S, Mishra DK, Dave TV, Naik MN
Indian J Ophthalmol 2015 Jul;63(7):620-2. doi: 10.4103/0301-4738.167106. PMID: 26458484Free PMC Article
Caruncular tumor as the first sign of T-cell lymphoma relapse.
Ting DS, Mansoor Q, Mathew S, Wride NK
Semin Ophthalmol 2015 Mar;30(2):139-41. Epub 2013 Oct 30 doi: 10.3109/08820538.2013.833260. PMID: 24171790
Benign neonatal hemangiomatosis with conjunctival involvement. Report of a case and review of the literature.
Baska EB, Baykara M, Saricaoglu H, Tunali S
Acta Derm Venereol 2002;82(2):124-7. doi: 10.1080/00015550252948176. PMID: 12125941
Malignant fibrous histiocytoma of the conjunctiva.
Pe'er J, Levinger S, Ilsar M, Climenhaga H, Okon E
Br J Ophthalmol 1990 Oct;74(10):624-8. doi: 10.1136/bjo.74.10.624. PMID: 1704795Free PMC Article

Clinical prediction guides

A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance.
Mudhar HS, Krishna Y, Cross S, Auw-Haedrich C, Barnhill R, Cherepanoff S, Eagle R, Farmer J, Folberg R, Grossniklaus H, Herwig-Carl MC, Hyrcza M, Lassalle S, Loeffler KU, Moulin A, Milman T, Verdijk RM, Heegaard S, Coupland SE
Lab Invest 2024 Jan;104(1):100281. Epub 2023 Nov 3 doi: 10.1016/j.labinv.2023.100281. PMID: 37924948
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
A unique case of isolated sebaceous adenoma of the bulbar conjunctiva.
Ilhan HD, Turkoglu EB, Bilgin AB, Bassorgun I, Dogan ME, Unal M
Arq Bras Oftalmol 2016 Jul-Aug;79(4):253-4. doi: 10.5935/0004-2749.20160071. PMID: 27626151
Epibulbar schwannoma in a 12-year-old boy: A case report and review of literature.
Nair AG, Kaliki S, Mishra DK, Dave TV, Naik MN
Indian J Ophthalmol 2015 Jul;63(7):620-2. doi: 10.4103/0301-4738.167106. PMID: 26458484Free PMC Article
Clinical diagnosis of tumors of the conjunctiva.
Bardenstein DS
Optom Clin 1993;3(3):29-47. PMID: 8199449

Recent systematic reviews

Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119

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