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Fatty streak

MedGen UID:
569155
•Concept ID:
C0333484
•
Finding
Synonyms: Fatty dots; Fatty streaks; Lipid streaks; Sudanophilic lesion; Yellow dots; Yellow streaks
SNOMED CT: Fatty streaks (53151000); Lipid streaks (53151000); Yellow streaks (53151000); Yellow dots (53151000); Fatty dots (53151000)
 
HPO: HP:0031011

Definition

Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV. [from HPO]

Professional guidelines

PubMed

Recent Advances in Understanding the Pathogenesis of Cardiovascular Diseases and Development of Treatment Modalities.
Mittal R, Jhaveri VM, Kay SS, Greer A, Sutherland KJ, McMurry HS, Lin N, Mittal J, Malhotra AK, Patel AP
Cardiovasc Hematol Disord Drug Targets 2019;19(1):19-32. doi: 10.2174/1871529X18666180508111353. PMID: 29737266
The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis.
Palinski W, Napoli C
FASEB J 2002 Sep;16(11):1348-60. doi: 10.1096/fj.02-0226rev. PMID: 12205026
Hypertension treatment and prevention of new atherosclerotic plaque formation.
Rafflenbeul W
Drugs 1994;48 Suppl 1:11-5. doi: 10.2165/00003495-199400481-00005. PMID: 7533701

Recent clinical studies

Etiology

Dyslipidemia in pregnancy and maternal-fetal outcome.
Nasioudis D, Doulaveris G, Kanninen TT
Minerva Ginecol 2019 Apr;71(2):155-162. Epub 2018 Oct 11 doi: 10.23736/S0026-4784.18.04330-7. PMID: 30318877
Imaging of the unstable plaque.
Tan KT, Lip GY
Int J Cardiol 2008 Jul 4;127(2):157-65. Epub 2008 Jan 22 doi: 10.1016/j.ijcard.2007.11.054. PMID: 18207257
PPARgamma and atherosclerosis.
Staels B
Curr Med Res Opin 2005;21 Suppl 1:S13-20. doi: 10.1185/030079905X36440. PMID: 15811195
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
Atherosclerosis and hypertension.
Matova EE, Vihert AM
Bull World Health Organ 1976;53(5-6):539-46. PMID: 1087193Free PMC Article

Diagnosis

Inflammation, atherosclerosis, and psoriasis.
Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I
Clin Rev Allergy Immunol 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. PMID: 22359071
Mechanisms of LDL oxidation.
Yoshida H, Kisugi R
Clin Chim Acta 2010 Dec 14;411(23-24):1875-82. Epub 2010 Sep 9 doi: 10.1016/j.cca.2010.08.038. PMID: 20816951
Imaging of the unstable plaque.
Tan KT, Lip GY
Int J Cardiol 2008 Jul 4;127(2):157-65. Epub 2008 Jan 22 doi: 10.1016/j.ijcard.2007.11.054. PMID: 18207257
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
Inflammation and infection in acute coronary syndrome.
Albert NM
J Cardiovasc Nurs 2000 Oct;15(1):13-26. doi: 10.1097/00005082-200010000-00003. PMID: 11061218

Therapy

Keep recycling going: New approaches to reduce LDL-C.
Klein-Szanto AJP, Bassi DE
Biochem Pharmacol 2019 Jun;164:336-341. Epub 2019 Apr 4 doi: 10.1016/j.bcp.2019.04.003. PMID: 30953636
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernandez-Hernando C, Suarez Y
Curr Vasc Pharmacol 2015;13(3):291-304. PMID: 26156264
Diet effects on atherosclerosis in mice.
Temel RE, Rudel LL
Curr Drug Targets 2007 Nov;8(11):1150-60. doi: 10.2174/138945007782403847. PMID: 18045093
PPARgamma and atherosclerosis.
Staels B
Curr Med Res Opin 2005;21 Suppl 1:S13-20. doi: 10.1185/030079905X36440. PMID: 15811195
Oxidized LDL and antioxidants.
Jialal I, Fuller CJ
Clin Cardiol 1993 Apr;16(4 Suppl 1):I6-9. doi: 10.1002/clc.4960161304. PMID: 8472396

Prognosis

How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis?
Welty FK
Curr Cardiol Rep 2013 Sep;15(9):400. doi: 10.1007/s11886-013-0400-4. PMID: 23881582Free PMC Article
Inflammation, atherosclerosis, and psoriasis.
Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I
Clin Rev Allergy Immunol 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. PMID: 22359071
C-reactive protein and atherogenesis: from fatty streak to clinical event.
Bisoendial RJ, Kastelein JJ, Stroes ES
Atherosclerosis 2007 Dec;195(2):e10-8. Epub 2007 Jul 31 doi: 10.1016/j.atherosclerosis.2007.04.053. PMID: 17669411
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture.
Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM
Arterioscler Thromb Vasc Biol 1996 Jul;16(7):831-42. doi: 10.1161/01.atv.16.7.831. PMID: 8673557

Clinical prediction guides

How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis?
Welty FK
Curr Cardiol Rep 2013 Sep;15(9):400. doi: 10.1007/s11886-013-0400-4. PMID: 23881582Free PMC Article
Inflammation, atherosclerosis, and psoriasis.
Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I
Clin Rev Allergy Immunol 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. PMID: 22359071
CRP and the risk of atherosclerotic events.
Calabrò P, Golia E, Yeh ET
Semin Immunopathol 2009 Jun;31(1):79-94. Epub 2009 May 5 doi: 10.1007/s00281-009-0149-4. PMID: 19415283
Macrophage differentiation to foam cells.
Shashkin P, Dragulev B, Ley K
Curr Pharm Des 2005;11(23):3061-72. doi: 10.2174/1381612054865064. PMID: 16178764
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971

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