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Iatrogenic or traumatic pituitary deficiency

MedGen UID:
575005
•Concept ID:
C0342400
•
Disease or Syndrome
Synonyms: Hypopituitarism secondary to head trauma; iatrogenic or traumatic pituitary deficiency; Post-traumatic hypopituitarism; Post-traumatic pituitary deficiency
SNOMED CT: Hypopituitarism secondary to head trauma (237699005); Post-traumatic hypopituitarism (237699005)
 
Monarch Initiative: MONDO:0019845
Orphanet: ORPHA95619

Definition

A rare, acquired, endocrine disorder characterized by deficiency of one or more of the pituitary hormones resulting as a consequence of traumatic or medically-induced injury of the pituitary gland. Clinical presentation is variable depending on the nature and acuity of the injury and the resulting order and amount of hormone deficiency. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIatrogenic or traumatic pituitary deficiency

Professional guidelines

PubMed

Diagnosis and management of bipolar disorders.
Goes FS
BMJ 2023 Apr 12;381:e073591. doi: 10.1136/bmj-2022-073591. PMID: 37045450
2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility.
Smith HAB, Besunder JB, Betters KA, Johnson PN, Srinivasan V, Stormorken A, Farrington E, Golianu B, Godshall AJ, Acinelli L, Almgren C, Bailey CH, Boyd JM, Cisco MJ, Damian M, deAlmeida ML, Fehr J, Fenton KE, Gilliland F, Grant MJC, Howell J, Ruggles CA, Simone S, Su F, Sullivan JE, Tegtmeyer K, Traube C, Williams S, Berkenbosch JW
Pediatr Crit Care Med 2022 Feb 1;23(2):e74-e110. doi: 10.1097/PCC.0000000000002873. PMID: 35119438
Metatarsalgia: anatomy, pathology and management.
Cooke R, Manning C, Palihawadana D, Zubairy AI, Khan SH
Br J Hosp Med (Lond) 2021 Sep 2;82(9):1-8. Epub 2021 Sep 29 doi: 10.12968/hmed.2021.0348. PMID: 34601927

Recent clinical studies

Etiology

ICU Delirium.
Sakusic A, Rabinstein AA
Neurol Clin 2025 Feb;43(1):1-13. Epub 2024 Sep 17 doi: 10.1016/j.ncl.2024.07.001. PMID: 39547734
Hypoglycaemia in adrenal insufficiency.
Lee SC, Baranowski ES, Sakremath R, Saraff V, Mohamed Z
Front Endocrinol (Lausanne) 2023;14:1198519. Epub 2023 Nov 20 doi: 10.3389/fendo.2023.1198519. PMID: 38053731Free PMC Article
Pediatric Moderate and Severe Traumatic Brain Injury: A Systematic Review of Clinical Practice Guideline Recommendations.
Ben Abdeljelil A, Freire GC, Yanchar N, Turgeon AF, Beno S, Bérubé M, Stang A, Stelfox T, Zemek R, Beaulieu E, Gagnon IJ, Gabbe B, Lauzier F, Labrosse M, Tardif PA, Deshommes T, Gnanvi J, Moore L
J Neurotrauma 2023 Nov;40(21-22):2270-2281. Epub 2023 Aug 16 doi: 10.1089/neu.2023.0149. PMID: 37341019
Avoid Iatrogenic Injuries.
Li JJ, Zhang H, Peng X, Yang SM, Bai JY, Fan CQ
Am J Gastroenterol 2023 Feb 1;118(2):202-203. Epub 2022 Sep 30 doi: 10.14309/ajg.0000000000002039. PMID: 36191272
Central diabetes insipidus in children: Diagnosis and management.
Patti G, Ibba A, Morana G, Napoli F, Fava D, di Iorgi N, Maghnie M
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101440. Epub 2020 Jun 29 doi: 10.1016/j.beem.2020.101440. PMID: 32646670

Diagnosis

ICU Delirium.
Sakusic A, Rabinstein AA
Neurol Clin 2025 Feb;43(1):1-13. Epub 2024 Sep 17 doi: 10.1016/j.ncl.2024.07.001. PMID: 39547734
Hypopituitarism.
Fleseriu M, Christ-Crain M, Langlois F, Gadelha M, Melmed S
Lancet 2024 Jun 15;403(10444):2632-2648. Epub 2024 May 9 doi: 10.1016/S0140-6736(24)00342-8. PMID: 38735295
Iatrogenic botulism.
Hagberg G, Skytøen ER, Nakstad I, O' Sullivan K, Koht J, Johansen TKB, Feruglio SL, Frøyshov S
Tidsskr Nor Laegeforen 2024 Feb 13;144(2) Epub 2024 Feb 12 doi: 10.4045/tidsskr.23.0625. PMID: 38349108
Diagnosis and Management of Central Diabetes Insipidus in Adults.
Tomkins M, Lawless S, Martin-Grace J, Sherlock M, Thompson CJ
J Clin Endocrinol Metab 2022 Sep 28;107(10):2701-2715. doi: 10.1210/clinem/dgac381. PMID: 35771962Free PMC Article
Central diabetes insipidus in children: Diagnosis and management.
Patti G, Ibba A, Morana G, Napoli F, Fava D, di Iorgi N, Maghnie M
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101440. Epub 2020 Jun 29 doi: 10.1016/j.beem.2020.101440. PMID: 32646670

Therapy

Hypoglycaemia in adrenal insufficiency.
Lee SC, Baranowski ES, Sakremath R, Saraff V, Mohamed Z
Front Endocrinol (Lausanne) 2023;14:1198519. Epub 2023 Nov 20 doi: 10.3389/fendo.2023.1198519. PMID: 38053731Free PMC Article
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
The management of menopause in women with a history of endometriosis: a systematic review.
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article
Rehabilitation following carpal tunnel release.
Peters S, Page MJ, Coppieters MW, Ross M, Johnston V
Cochrane Database Syst Rev 2016 Feb 17;2(2):CD004158. doi: 10.1002/14651858.CD004158.pub3. PMID: 26884379Free PMC Article
Iatrogenics.
Cade S
Clin Radiol 1966 Jul;17(3):193-202. doi: 10.1016/s0009-9260(66)80025-9. PMID: 5942770

Prognosis

Endocrinology Update: Hypopituitarism.
Heidelbaugh JJ
FP Essent 2016 Dec;451:25-30. PMID: 27936532
Iatrogenic atrial septal defect following transseptal cardiac interventions.
Alkhouli M, Sarraf M, Zack CJ, Holmes DR, Rihal CS
Int J Cardiol 2016 Apr 15;209:142-8. Epub 2016 Feb 6 doi: 10.1016/j.ijcard.2016.02.068. PMID: 26894464
Esophageal perforation.
Nirula R
Surg Clin North Am 2014 Feb;94(1):35-41. Epub 2013 Nov 5 doi: 10.1016/j.suc.2013.10.003. PMID: 24267495
Medically indicated--iatrogenic prematurity.
Wong AE, Grobman WA
Clin Perinatol 2011 Sep;38(3):423-39. Epub 2011 Jul 23 doi: 10.1016/j.clp.2011.06.002. PMID: 21890017
Coronary artery aneurysms.
Chrissoheris MP, Donohue TJ, Young RS, Ghantous A
Cardiol Rev 2008 May-Jun;16(3):116-23. doi: 10.1097/CRD.0b013e31815d0573. PMID: 18414182

Clinical prediction guides

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae.
Pavlovic D, Pekic S, Stojanovic M, Popovic V
Pituitary 2019 Jun;22(3):270-282. doi: 10.1007/s11102-019-00957-9. PMID: 30929221
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Endocrine Hypertension: A Practical Approach.
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Recent systematic reviews

Pediatric Moderate and Severe Traumatic Brain Injury: A Systematic Review of Clinical Practice Guideline Recommendations.
Ben Abdeljelil A, Freire GC, Yanchar N, Turgeon AF, Beno S, Bérubé M, Stang A, Stelfox T, Zemek R, Beaulieu E, Gagnon IJ, Gabbe B, Lauzier F, Labrosse M, Tardif PA, Deshommes T, Gnanvi J, Moore L
J Neurotrauma 2023 Nov;40(21-22):2270-2281. Epub 2023 Aug 16 doi: 10.1089/neu.2023.0149. PMID: 37341019
Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation.
Uttley L, Carroll C, Wong R, Hilton DA, Stevenson M
Lancet Infect Dis 2020 Jan;20(1):e2-e10. doi: 10.1016/S1473-3099(19)30615-2. PMID: 31876504
Functional cognitive disorders: a systematic review.
McWhirter L, Ritchie C, Stone J, Carson A
Lancet Psychiatry 2020 Feb;7(2):191-207. Epub 2019 Nov 12 doi: 10.1016/S2215-0366(19)30405-5. PMID: 31732482
Long-Term Impact of Iatrogenic Bile Duct Injury.
Schreuder AM, Busch OR, Besselink MG, Ignatavicius P, Gulbinas A, Barauskas G, Gouma DJ, van Gulik TM
Dig Surg 2020;37(1):10-21. Epub 2019 Jan 17 doi: 10.1159/000496432. PMID: 30654363Free PMC Article
The oral health of people with anxiety and depressive disorders - a systematic review and meta-analysis.
Kisely S, Sawyer E, Siskind D, Lalloo R
J Affect Disord 2016 Aug;200:119-32. Epub 2016 Apr 21 doi: 10.1016/j.jad.2016.04.040. PMID: 27130961

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