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Benign neoplasm of cornea

MedGen UID:
57579
•Concept ID:
C0154026
•
Neoplastic Process
Synonyms: Benign Cornea Neoplasm; benign cornea neoplasm; Benign Cornea Tumor; benign cornea tumor; benign cornea tumour; Benign Corneal Neoplasm; benign corneal neoplasm; Benign Corneal Tumor; benign corneal tumor; benign corneal tumour; Benign Neoplasm of Cornea; benign neoplasm of cornea; Benign Neoplasm of the Cornea; benign neoplasm of the cornea; Benign tumor of cornea; Benign Tumor of Cornea; benign tumor of cornea; Benign Tumor of the Cornea; benign tumor of the cornea; benign tumour of cornea; benign tumour of the cornea; cornea benign neoplasm
SNOMED CT: Benign tumor of cornea (92070006); Benign neoplasm of cornea (92070006)
 
Monarch Initiative: MONDO:0021452

Definition

A neoplasm that arises from the cornea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of cornea

Professional guidelines

PubMed

Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma.
Francis JH, Marr BP, Schaiquevich P, Kellick MG, Abramson DH
Br J Ophthalmol 2015 Oct;99(10):1320-2. Epub 2015 Apr 29 doi: 10.1136/bjophthalmol-2015-306633. PMID: 25926516
Diagnosis and treatment of hypercalcaemia.
Watson L
Br Med J 1972 Apr 15;2(5806):150-2. doi: 10.1136/bmj.2.5806.150. PMID: 4552807Free PMC Article

Recent clinical studies

Etiology

Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study.
Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW
Lancet Oncol 2022 Nov;23(11):1430-1440. Epub 2022 Oct 14 doi: 10.1016/S1470-2045(22)00603-9. PMID: 36244398
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Ocular surface squamous neoplasia.
Kiire CA, Srinivasan S, Karp CL
Int Ophthalmol Clin 2010 Summer;50(3):35-46. doi: 10.1097/IIO.0b013e3181e246e5. PMID: 20611016
Ocular choristomas.
Mansour AM, Barber JC, Reinecke RD, Wang FM
Surv Ophthalmol 1989 Mar-Apr;33(5):339-58. doi: 10.1016/0039-6257(89)90011-8. PMID: 2655139

Diagnosis

Migratory subconjunctival cyst.
Daher ND, Milman T, Syed ZA
J Fr Ophtalmol 2023 Nov;46(9):1122-1123. Epub 2023 Jul 4 doi: 10.1016/j.jfo.2023.01.039. PMID: 37414670
Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Traumatic corneal cyst.
Ghosh A, Radhakrishnan N, Prajna VN
Indian J Ophthalmol 2019 Jul;67(7):1179. doi: 10.4103/ijo.IJO_1822_18. PMID: 31238449Free PMC Article
Corneal snowflakes.
Huang YH, Tseng SH
Lancet 2012 Aug 4;380(9840):506. Epub 2012 May 7 doi: 10.1016/S0140-6736(12)60162-7. PMID: 22569280

Therapy

Erlotinib-induced dry eye.
Ravisankar R, Mohankumar A, Shivananda N
Indian J Ophthalmol 2023 Apr;71(4):1657-1658. doi: 10.4103/IJO.IJO_2582_22. PMID: 37026321Free PMC Article
Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study.
Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW
Lancet Oncol 2022 Nov;23(11):1430-1440. Epub 2022 Oct 14 doi: 10.1016/S1470-2045(22)00603-9. PMID: 36244398
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Corneal microcysts.
Dhillon VK, Faraj LA, Elalfy MS, Bhatt U, Said DG, Dua HS
Br J Ophthalmol 2014 Jan;98(1):138, 147-8. Epub 2013 Oct 4 doi: 10.1136/bjophthalmol-2013-303705. PMID: 24096522
Corneal snowflakes.
Huang YH, Tseng SH
Lancet 2012 Aug 4;380(9840):506. Epub 2012 May 7 doi: 10.1016/S0140-6736(12)60162-7. PMID: 22569280

Prognosis

HLA-G Neo-Expression on Tumors.
Loustau M, Anna F, Dréan R, Lecomte M, Langlade-Demoyen P, Caumartin J
Front Immunol 2020;11:1685. Epub 2020 Aug 14 doi: 10.3389/fimmu.2020.01685. PMID: 32922387Free PMC Article
Ophthalmology in Critical Care.
Parekh PH, Boente CS, Boente RD, Meeker JW, Carlos WG
Ann Am Thorac Soc 2019 Aug;16(8):957-966. doi: 10.1513/AnnalsATS.201812-848CME. PMID: 31091984
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Epithelial, non-melanocytic and melanocytic proliferations of the ocular surface.
Kheir WJ, Tetzlaff MT, Pfeiffer ML, Mulay K, Ozgur O, Morrell G, Esmaeli B
Semin Diagn Pathol 2016 May;33(3):122-32. Epub 2015 Oct 9 doi: 10.1053/j.semdp.2015.10.006. PMID: 27021909
Diffuse infiltrating retinoblastoma.
Morgan G
Br J Ophthalmol 1971 Sep;55(9):600-6. doi: 10.1136/bjo.55.9.600. PMID: 4106451Free PMC Article

Clinical prediction guides

Netarsudil-induced corneal honeycombing in childhood glaucomas.
Gupta S, Mahalingam K, Arora M, Singh A, Optom B, Kumari S, Gupta V
J AAPOS 2022 Oct;26(5):257-260. Epub 2022 Sep 13 doi: 10.1016/j.jaapos.2022.07.005. PMID: 36113700
Actinic Granuloma of the Conjunctiva: Case Series and Review of the Literature.
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Shave Excision With Keratopigmentation for Limbal Dermoid.
Bandivadekar P, Agarwal T, Temkar S
Eye Contact Lens 2018 Mar;44(2):e7-e9. doi: 10.1097/ICL.0000000000000257. PMID: 27058832
Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma.
Francis JH, Marr BP, Schaiquevich P, Kellick MG, Abramson DH
Br J Ophthalmol 2015 Oct;99(10):1320-2. Epub 2015 Apr 29 doi: 10.1136/bjophthalmol-2015-306633. PMID: 25926516

Recent systematic reviews

Adenosquamous proliferation in radial sclerosing lesions: Histologic spectrum and key features in systematic review of 247 lesions.
Bachert SE, Cornea V, Bocklage T
Breast 2023 Oct;71:99-105. Epub 2023 Aug 7 doi: 10.1016/j.breast.2023.08.002. PMID: 37566996Free PMC Article
The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.
Chinnery HR, Rajan R, Jiao H, Wu M, Zhang AC, De Silva MEH, Makrai E, Stepp MA, Di Girolamo N, Downie LE
Br J Ophthalmol 2022 Jun;106(6):765-771. Epub 2021 Feb 10 doi: 10.1136/bjophthalmol-2020-318156. PMID: 33568390Free PMC Article
Changes in visual function and ocular morphology in women who have undergone ART treatment and children born as a result of ART treatment: a systematic review.
Toro MD, Reibaldi M, Longo A, Avitabile T, Lionetti ME, Tripodi S, Posarelli C, Palomba S
Reprod Biomed Online 2019 Apr;38(4):621-633. Epub 2018 Dec 7 doi: 10.1016/j.rbmo.2018.11.007. PMID: 30795976

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